Protein Alignment C4A and Tep2

DIOPT Version :9

• Sequence 1: NP_009224.2
• Gene: C4A / 720
• HGNCID: 1323
• Length: 1744
• Species: Homo sapiens
• Sequence 2: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Alignment Length: 1566
• Identity: 385/1566 - (24%)
• Similarity: 657/1566 - (41%)
• Gaps: 360/1566 - (22%)

Human   132 LLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPS--TDTITVMVENSHGLRVRK-KEVYM 193
            |.::.::..:|:|||:..|.|...|::|:..||:..||:  ...|:|::.:....|::: .:|.:
  Fly   107 LNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKL 171

Human   194 PSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPYILTVPGH 258
            ...:|..:..:.:....||||||... || ::..:..|||.|||||.|||.:...|..::.
  Fly   172 TKGVFSGELQLSEQPVLGTWKISVSV-DG-DNRETKSFEVDKYVLPKFEVIVDTPKAVVIA---- 230

Human   259 LDE-MQLDIQARYIYGKPVQGVA-------YVRFGLLDEDGKKTFFRGLESQTKLVNGQSHISLS 315
             |: ::..|:|:|.|||||:|.|       |..||.|:.:|.|      :.:|..|:|:.|:
  Fly   231 -DKVIKATIRAKYTYGKPVKGKATVSMERSYGYFGDLNANGNK------QEKTIDVDGKGHV--- 285

Human   316 KAEFQDALEKLNMGITDLQGLRLYVAAAIIESPGGEMEEAELTSWYFVSSPFSLDLSKTKRHLVP 380
              || |.:.....| ..|..::|:  |.:.|...|..:.|..|. ......:|::..:...|...
  Fly   286 --EF-DIIHWAQRG-QYLPPIKLF--AVVTEELTGNKQNATATV-VLHQQRYSIEPYERPEHFEA 343

Human   381 GAPFLLQALVREMSGSPA--SGIPVKVSATVS-----SPGSVPEVQDIQQNTDGSGQVSIPIIIP 438
            ...|:.|.:|:.:.|||.  |...||:....|     .|.....: :.:...:.:|..:..:.:|
  Fly   344 NKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRI-NFEAPVNENGIATFNVRLP 407

Human   439 QTISE-LQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERPDSRPPRVGDTLNLNLRAVGSGATF 502
            .:.|. .::..|.......|..::...|.......|.|: .:::.||:|:.::.::.::   ...
  Fly   408 DSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQ-VNTKKPRLGEQVSFDVVSI---EDL 468

Human   503 SHYYYMILSRGQIVFMNREPKRTLTSVSVFVDHHLAPSFYFVAF--------------YYHGDHP 553
            .::.|.|::||.::            :|.:||.......|.|.|              ||    .
  Fly   469 PYFVYTIVARGNVI------------LSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYY----V 517

Human   554 VANSLRVDVQAGACEGKLELSVDGAKQYRN------------GESVKLHLETDSLALVALGALDT 606
            |.|.|:.:          |.::|..|::.|            .|.|||.::||:.:.|.|..:|.
  Fly   518 VNNDLQFE----------EKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTDADSFVGLLGVDQ 572

Human   607 ALYAAGSKSHKPLNMGKVFEAMNSYDL------GCG--PGGGDSALQVFQAAGLAFSDGDQWTLS 663
            ::...  ||...|:...:|.::|.|..      |.|  ||         |.:||.       ||:
  Fly   573 SVLLL--KSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPG---------QTSGLV-------TLT 619

Human   664 RKRLSCPKEKTTRKKRNVNFQKAINEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDC 728
                            |.|           |...|.           |::.|.....:
  Fly   620 ----------------NAN-----------YPYNTG-----------PLVMSYVFEGS------- 639

Human   729 REPFLSCCQFAESLRKKSRDK----GQAGLQRAL-EILQEEDLIDEDDIPVRSFFPENWLWRVET 788
            |.|:::..::...:|..|.|:    .|:...|.| |||.::   ......:|..|||.|.:....
  Fly   640 RHPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQ---TPQRTTIRKEFPETWFFENVG 701

Human   789 VDRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVA-TPVQLRVFREFHLHLRLPMSVRRFEQLELR 852
            .:.| .||..:||::|:|.:.|.||:.|.|:.:. .|.::|||:.|.:...||.||:|.|.:.:.
  Fly   702 EEEF-TLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIP 765

Human   853 PVLYNYLDKNLTVSV---------------------HVSPVEGLCLAGGGGLAQQVLVPAGSARP 896
            .|::|||||.|...|                     .:..|..:         ::|.:||.|.:.
  Fly   766 VVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRV---------KRVTIPANSGKS 821

Human   897 VAFSVVPTAAAAVSLKVVARGSFEFPVGDAVSKVLQIEKEGAIHREELVYELNPLDHRGRTLEIP 961
            |:|.:.|......:||:.|..:.   .|||:.:.|::|.||....|.....:|..|....:..:.
  Fly   822 VSFMIRPKNVGFTTLKITATSAL---AGDAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQSLD 883

Human   962 GNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASR 1026
            .:....::|..:|..:..|.     |.||.    :...:.:|:|:|.|||||.|:...|.:...:
  Fly   884 ADIPNEVVPQSEFIEFSVVG-----DLLGP----TLQNLDNLVRMPYGCGEQNMVNFVPNILVLK 939

Human  1027 YLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRKADGSYAAWLSRDS--STWLTAFVLKVLSLA 1089
            ||:.|   ....|..:..|...::.||.|...::..||||:|:...|:  ||||||:|::....|
  Fly   940 YLEVT---GRKLPSVESKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQA 1001

Human  1090 QEQVGGSPEKLQETSNWLLSQQQADGSFQDPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLA 1154
            .......|:.:....::|:|:|:..|.|.:...:.|.:       |...:|||:||.      ||
  Fly  1002 GTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNA-------NQNPLALTSFVL------LA 1053

Human  1155 VFQDEGAEPLKQRVEASISKANSFLGEKASAGLLGAHAAAITAYALTLTKAPVDLLGVAHNNLMA 1219
            .|::....|   :.:::|.||..::.|:|.. ....::.||.|.||.|.|.|.....:|  .|.:
  Fly  1054 FFENHELIP---KYQSAIKKAVRYVAEEADK-TDDQYSLAIAAVALQLAKHPQSEKVIA--KLES 1112

Human  1220 MAQETGDNLYWGSV---TGSQSNAVSPTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEGKAEM 1281
            :|::..|.::|...   ||.........|...:            :|.|:|.|| .||.:..||.
  Fly  1113 VARKENDRMWWSKATESTGEDGRVFHWKPRSND------------VEITSYVLL-ALLEKDPAEK 1164

Human  1282 ADQASAWLTRQGSFQGGFRSTQDTVIALDALSAYWIASHTTEERG-LNVTLSSTGRNGFKSHALQ 1345
            |.....||..|.:..|||.|||||||.|.||:.:  |..|....| :::..||.|.
  Fly  1165 ALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKF--AYKTGSGSGTMDIEFSSAGE--------- 1218

Human  1346 LNNRQIRGLEEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYT 1410
                              ||..:||  |.:.:| ||:|:   |:..:|   .:::.|.||.....
  Fly  1219 ------------------SKNTIKV--NPENSL-VLQTH---DLPKST---RKVDFTAKGTGSAM 1256

Human  1411 MEANEDYEDYEYDELPA-------KDDPDAPL-----QPVTPLQLFEGRRNRRRREAPKVVEEQE 1463
            ::.:..|...|.::.|:       ||.|:..|     ....||:           :|.|..:
  Fly  1257 VQLSYRYNLAEKEKKPSFKVTPTVKDTPNQLLIVDVCAEYVPLE-----------DADKDKD--- 1307

Human  1464 SRVHYTVCIWRNGKVGLSGMAIADVTLLSGFHALRADLEKLTSLSDRYVSHFETEGPH--VLLYF 1526
                             |.||:.::.|.|||......|.|:.:: || |...||:...  |::||
  Fly  1308 -----------------SNMAVMEIALPSGFVGDSTSLGKIQAV-DR-VKRVETKNSDSTVVVYF 1353

Human  1527 DSV-PTSRECVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVCQ- 1589
            ||: |....|:..||.:...|...:|||.:|||||:.||:.:.:|      ::.::||  ::|:
  Fly  1354 DSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYY------QVKSSLC--DICEG 1410

Human  1590 --CAEG 1593
              |.||
  Fly  1411 ADCGEG 1416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C4A	NP_009224.2	A2M_N	141..233	CDD:280081	26/94 (28%)
		A2M_N	141..233		26/94 (28%)
		A2M_N_2	478..610	CDD:285005	31/157 (20%)
		A2M_N_2	478..610		31/157 (20%)
		ANATO	686..750	CDD:237984	9/67 (13%)
		ANATO	686..750		9/67 (13%)
		A2M	782..869	CDD:278630	32/108 (30%)
		A2M	782..869		32/108 (30%)
		complement_C3_C4_C5	996..1315	CDD:239226	96/323 (30%)
		complement_C3_C4_C5	996..1315		96/323 (30%)
		A2M_comp	1051..1317	CDD:284982	81/270 (30%)
		A2M_comp	1051..1317		81/270 (30%)
		A2M_recep	1481..1570	CDD:284981	34/91 (37%)
		A2M_recep	1481..1570		34/91 (37%)
		NTR_complement_C4	1588..1742	CDD:239639	4/9 (44%)
		NTR_complement_C4	1588..1742		4/9 (44%)
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	26/95 (27%)
		A2M_N_2	445..576	CDD:285005	32/160 (20%)
		A2M	694..782	CDD:278630	32/88 (36%)
		A2M_2	909..1198	CDD:239227	96/323 (30%)
		A2M_comp	961..1199	CDD:284982	81/271 (30%)
		A2M_recep	1308..1398	CDD:284981	34/91 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149976
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810