DRSC/TRiP Functional Genomics Resources

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Protein Alignment C3AR1 and TkR86C

DIOPT Version :9

Sequence 1:NP_001313404.1 Gene:C3AR1 / 719 HGNCID:1319 Length:482 Species:Homo sapiens
Sequence 2:NP_001097741.1 Gene:TkR86C / 41286 FlyBaseID:FBgn0004841 Length:555 Species:Drosophila melanogaster


Alignment Length:501 Identity:101/501 - (20%)
Similarity:166/501 - (33%) Gaps:197/501 - (39%)


- Green bases have known domain annotations that are detailed below.


Human     4 FSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLW-VAGLKMQRTVNTIWFLHLTLA 67
            |.:.|...:|   ||.:..:  ..:|..|...:.:.|||:||| |.|.:..|||...:.|:|::|
  Fly    69 FPSPTRPYEL---PWEQKTI--WAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIA 128

Human    68 DLL-----CCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKP 127
            |||     |..:..|     .|...||:|...|.:...:..:.:..|||.|.|||.||.:.:..|
  Fly   129 DLLMSSLNCVFNFIF-----MLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHP 188

Human   128 IWCQ-NHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYKFGLSSSLDYPDFYGDP 191
            :..: :.|.|.:   |...||.::.|:..|..:|..|.|...:|                     
  Fly   189 LKRRTSRRKVRI---ILVLIWALSCVLSAPCLLYSSIMTKHYYN--------------------- 229

Human   192 LENRSLENIVQPPGEMNDRLDPSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYS 256
                                                                 |.:|.....:: 
  Fly   230 -----------------------------------------------------GKSRTVCFMMW- 240

Human   257 NVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDY-YNL 320
                         |.|                                    ..|....|| |||
  Fly   241 -------------PDG------------------------------------RYPTSMADYAYNL 256

Human   321 GQFTDDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRF----------------- 368
                              ..||:.:.:|.::|:.|||.:      ||.                 
  Fly   257 ------------------IILVLTYGIPMIVMLICYSLM------GRVLWGSRSIGENTDRQMES 297

Human   369 AKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIA---LASANSCF 430
            .||:.|..|:.:.:|::|.:||.|||:|.:.:...: :....|.:   .|:.:.   ||.:|:..
  Fly   298 MKSKRKVVRMFIAIVSIFAICWLPYHLFFIYAYHNN-QVASTKYV---QHMYLGFYWLAMSNAMV 358

Human   431 NPFLYALLGKDFRKKARQSI----QGILEAAFSEELTRSTHCPSNN 472
            ||.:|..:.|.||...::.|    .|:....|....:|.|:..|:|
  Fly   359 NPLIYYWMNKRFRMYFQRIICCCCVGLTRHRFDSPKSRLTNKNSSN 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3AR1NP_001313404.1 7tmA_C3aR 24..446 CDD:320243 89/449 (20%)
TM helix 1 25..51 CDD:320243 10/26 (38%)
TM helix 2 57..82 CDD:320243 8/29 (28%)
TM helix 3 95..125 CDD:320243 10/29 (34%)
TM helix 4 137..157 CDD:320243 4/19 (21%)
TM helix 5 333..358 CDD:320243 6/24 (25%)
TM helix 6 370..400 CDD:320243 12/29 (41%)
TM helix 7 414..439 CDD:320243 7/27 (26%)
TkR86CNP_001097741.1 7tm_4 92..376 CDD:304433 88/443 (20%)
7tm_1 100..363 CDD:278431 83/422 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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