Protein Alignment TRAF6 and Traf4

DIOPT Version :9

• Sequence 1: NP_004611.1
• Gene: TRAF6 / 7189
• HGNCID: 12036
• Length: 522
• Species: Homo sapiens
• Sequence 2: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 483
• Identity: 111/483 - (22%)
• Similarity: 174/483 - (36%)
• Gaps: 123/483 - (25%)

Human    85 CGHRFCKACIIKSIRDAGHKCPV---DNEIL----LENQLFPDNFAKREILSLMVKC--PNEGCL 140
            |......:..:.|...:.|..|.   :|..:    ||..::|....| .|:..:|.|  ..:||.
  Fly    51 CATSRSSSSTVSSSHSSSHSSPTPGNNNNNMPITELEQIIYPGPDPK-HIMGSLVFCIHHKQGCK 114

Human   141 HKMELRHLEDHQAHCEFALMDCPQ----------------------------CQRPFQ------- 170
            ...|||.|:.|...|:.....||.                            ||..|.
  Fly   115 WSDELRKLKGHLNACKHDATQCPNKCGAQIPRIMMTDHLQYTCTMRRTRCEFCQSEFSGAGLEEH 179

Human   171 --------------------KFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVIC 215
                                :..:.:|..|||.:|...|.:|....:.:...:|...||.|.:.|
  Fly   180 NGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLAC 244

Human   216 -EYCNTILI-REQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVH 278
             :.|:...| |.::..|...:|.:..:.|:|...||..|..|..|..||:.|..:|:
  Fly   245 PQRCDAGPIPRGELEAHLRDECQSLAVSCSFKEAGCRFKGPRQMLEAHLESNAAAHL-------- 301

Human   279 SLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAE 343
            ||.|...|                     ||..||:.|.:.:...|:
  Fly   302 SLMVALSS---------------------RQGQQIQMLKSAVSKLSI------------------ 327

Human   344 IEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKL--CMRLHLQLPTAQRCANY 406
                ...|..:|||.::...:.....:..:.:.||.|||.:.||||  .|.|:...|...   .:
  Fly   328 ----NYTGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGEN---TH 385

Human   407 ISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGF 471
            :|:::..:.||||:.|.|||..:|..|:.:|.....:....|.....|....||||:...:..||
  Fly   386 VSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGF 450

Human   472 GYVTFMHLEALRQRTFIKDDTLLVRCEV 499
            |:..|:..|.|..|.|||.||:.:|.:|
  Fly   451 GFPRFISHELLHSRPFIKGDTVFLRVKV 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRAF6	NP_004611.1	Interaction with TAX1BP1. /evidence=ECO:0000269|PubMed:10920205	1..354		64/334 (19%)
		RING	69..107	CDD:238093	3/21 (14%)
		zf-TRAF	204..261	CDD:280357	17/58 (29%)
		MATH_TRAF6	351..500	CDD:239745	48/151 (32%)
		Interaction with TANK. /evidence=ECO:0000269|PubMed:25861989	355..522		47/147 (32%)
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	13/96 (14%)
		zf-TRAF	233..292	CDD:424248	17/58 (29%)
		MATH_TRAF4	331..479	CDD:239750	48/151 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920