DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRAF2 and Traf4

DIOPT Version :9

Sequence 1:	NP_066961.2	Gene:	TRAF2 / 7186	HGNCID:	12032	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_477416.1	Gene:	Traf4 / 33638	FlyBaseID:	FBgn0026319	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	118/478 - (24%)
Similarity:	187/478 - (39%)	Gaps:	122/478 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    58 LASILSSGPQ------NCAACVHEGIYEEGISILESSSAFPD--NAARREVESLPAVCPSD---- 110
            |..|:..||.      :...|:|   :::|....:.......  ||.:.:....|..|.:.
  Fly    86 LEQIIYPGPDPKHIMGSLVFCIH---HKQGCKWSDELRKLKGHLNACKHDATQCPNKCGAQIPRI 147

Human   111 --------GCTWKGTLKEYESC-----------HEGRCPLMLTECPA-CKGLVRLGEKERHLEHE 155
                    .||.:.|..|:  |           |.|.|......|.| |...:..|....|...:
  Fly   148 MMTDHLQYTCTMRRTRCEF--CQSEFSGAGLEEHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKD 210

Human   156 CPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTC-DGCGKKKIPREKFQDHVK-TCGKCRVPCRF 218
            |.:|...|.||:.......:..|...||:.||.| ..|....|||.:.:.|:: .|....|.|.|
  Fly   211 CAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSF 275

Human   219 HAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFE 283
            ...||  ..:|.:|.      |..||                :|:|.:.|
  Fly   276 KEAGC--RFKGPRQM------LEAHL----------------ESNAAAHL--------------- 301

Human   284 NIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEAS 348
                         ::.....|||.:    :|:.|.|.|.:|                      :.
  Fly   302 -------------SLMVALSSRQGQ----QIQMLKSAVSKL----------------------SI 327

Human   349 TYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVV 413
            .|.|..:|||:|::.|..||.......:.||.||||:||||:...::|||:|.|..||:|::..|
  Fly   328 NYTGTLLWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKV 392

Human   414 MKGPNDALLRWPFNQKVTLMLLD---QNNREHVIDAFRPDVTSSSFQRPVNDMN-IASGCPLFCP 474
            :.|..||||:|||:..:|..|.:   |:.:..|.::|.||.|..:||||.|:.: :..|.|.|..
  Fly   393 LPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFIS 457

Human   475 VSKMEAKNSYVRDDAIFIKAIVD 497
            ...:.:: .:::.|.:|::..||
  Fly   458 HELLHSR-PFIKGDTVFLRVKVD 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRAF2	NP_066961.2	RAD18	28..>157	CDD:333230	24/130 (18%)
		RING-HC_TRAF2	32..73	CDD:319553	4/20 (20%)
		RING-HC finger (C3HC4-type)	34..72	CDD:319553	4/19 (21%)
		zf-TRAF	178..235	CDD:280357	19/58 (33%)
		TRAF_BIRC3_bd	267..329	CDD:318808	9/61 (15%)
		Important for interaction with BIRC2 and BIRC3. /evidence=ECO:0000250	283..293		0/9 (0%)
		MATH_TRAF2	334..497	CDD:239747	54/166 (33%)
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	17/98 (17%)
		zf-TRAF	233..292	CDD:424248	20/66 (30%)
		MATH_TRAF4	331..479	CDD:239750	53/148 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950