DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRAF1 and Traf4

DIOPT Version :9

Sequence 1:	NP_001177874.1	Gene:	TRAF1 / 7185	HGNCID:	12031	Length:	416	Species:	Homo sapiens
Sequence 2:	NP_477416.1	Gene:	Traf4 / 33638	FlyBaseID:	FBgn0026319	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	127/475 - (26%)
Similarity:	190/475 - (40%)	Gaps:	121/475 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     3 SSSGSSPRPAPDENEFPFGCPPTVCQDPKEPR------ALCC---AGC-LSENPRNGEDQI---- 53
            |||.|||.|..:.|..|......:.....:|:      ..|.   .|| .|:..|..:..:
  Fly    66 SSSHSSPTPGNNNNNMPITELEQIIYPGPDPKHIMGSLVFCIHHKQGCKWSDELRKLKGHLNACK 130

Human    54 -----CPKCRGEDLQSISPGSRLR---TQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVT 110
                 ||...|..:..|.....|:   |..:...|..::    .|:|.|         ::||.
  Fly   131 HDATQCPNKCGAQIPRIMMTDHLQYTCTMRRTRCEFCQS----EFSGAG---------LEEHN-- 180

Human   111 SQTSHLNLLLGFMKQ----WKARLGCGLESGPMAL------------------EQNLSDLQLQAA 153
                      |...|    .:|:.|..:..|.|.|                  |.:...|.|.||
  Fly   181 ----------GSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAA 235

Human   154 VEVAGDLEVDCYRAP--CSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEA------ 210
                     .|.|||  |.:..:...:..       .|||..||.....:||.....||
  Fly   236 ---------QCPRAPLACPQRCDAGPIPR-------GELEAHLRDECQSLAVSCSFKEAGCRFKG 284

Human   211 ------SHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTF 269
                  :||....:.|         |||   :|.|.....|:.|.|......|.:    ::.||.
  Fly   285 PRQMLEAHLESNAAAH---------LSL---MVALSSRQGQQIQMLKSAVSKLSI----NYTGTL 333

Human   270 LWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYD 334
            |||||:.:.:..|:.....:.|.||.|||::|||||...::|||:|.|:.||:|::|.::.||||
  Fly   334 LWKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYD 398

Human   335 ALLPWPFRNKVTFMLLD---QNNREHAIDAFRPDLSSASFQRPQSETN-VASGCPLFFPLSKLQS 395
            |||.|||.:.:||.|.:   |:.:....::|.||.:..:||||.:|.: :..|.|.|.....|.|
  Fly   399 ALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFISHELLHS 463

Human   396 PKHAYVKDDTMFLKCIVETS 415
              ..::|.||:||:..|:.|
  Fly   464 --RPFIKGDTVFLRVKVDPS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRAF1	NP_001177874.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		9/20 (45%)
		SMC_N	<140..>263	CDD:330553	32/154 (21%)
		TRAF_BIRC3_bd	184..244	CDD:318808	17/71 (24%)
		MATH_TRAF1	267..413	CDD:239748	60/149 (40%)
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	22/121 (18%)
		zf-TRAF	233..292	CDD:424248	16/74 (22%)
		MATH_TRAF4	331..479	CDD:239750	60/149 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950