DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSP90B1 and Trap1

DIOPT Version :10

Sequence 1:NP_003290.1 Gene:HSP90B1 / 7184 HGNCID:12028 Length:803 Species:Homo sapiens
Sequence 2:NP_477439.2 Gene:Trap1 / 35559 FlyBaseID:FBgn0026761 Length:691 Species:Drosophila melanogaster


Alignment Length:773 Identity:237/773 - (30%)
Similarity:387/773 - (50%) Gaps:119/773 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVV---QREEEAIQLDGLN 62
            :||:.|||..|.|               |...:.|.:|...:.....:.   |....|:.|...:
  Fly     3 VRAMGVLGQACRL---------------GRCAQVLRQSHRSAPAAFNITIGSQHSPGALSLRRYS 52

Human    63 ASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLT--DENA 125
            ....:......:|..||||..:::.::..|||.:.|:|:|||||||||||:|.|..||:  .||.
  Fly    53 TETKQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENL 117

Human   126 LSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQE--DGQST 188
            ...:..|.::|..||....|.:.|||:|||:||||.||||||:||:.:||.:|...|:  ..:::
  Fly   118 AGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEAS 182

Human   189 SELIGQFGVGFYSAFLVADKVIVTSKH--NNDTQHIWESDSN---EFSVIADPRGNTLGRGTTIT 248
            |.:||||||||||:|:||:||.|.::.  .|.....|.:|.:   |...:.|     :..||.|.
  Fly   183 SNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPD-----VELGTRIV 242

Human   249 LVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVE 313
            |.||.:..:|.:.:.||.::||||.|:..||.:                                
  Fly   243 LHLKTDCREYADEERIKAVIKKYSNFVGSPILL-------------------------------- 275

Human   314 EEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAE 378
                              :.:..|:|||:|....:.:.::::..||:..|...|.|...:|:.|:
  Fly   276 ------------------NGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNAD 322

Human   379 GEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLP 443
            ..::..::|:.|...| ||| |.....:..:.||.|:|.|......::||:|.||||||||:|:|
  Fly   323 VPLSIHALLYFPEGKP-GLF-EMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIP 385

Human   444 LNVSRETLQQ----HKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVI--EDHSN 502
            ||:|||.||.    .||..||..:::|...:..|| ..::| :.|::::|..:|.|::  .|.|.
  Fly   386 LNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKK-QPEEY-EAFYRDYGLFLKEGIVTSSDASE 448

Human   503 RTRLAKLLRFQSSHHPT--DITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEV 565
            :..:||||||:||...|  ...||::|...:..:|..||::|..:|..|||||:.|.|.|:...|
  Fly   449 KEEIAKLLRFESSKSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELV 513

Human   566 IYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESRE-----AVEKEFEPLLNWMKDK 625
            ::..||.||..:..|.:|..|:..:|.||  ..:||::|..:.:     .:..|.:.|:.|::::
  Fly   514 LFCYEPYDELVLMQLGKFKSKKLVSVEKE--MREESKETTATTDFGEGSLLRSELDTLIPWLEEE 576

Human   626 ALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPR 690
             |:.::.|...:.||...||.:...:...:   ...::.|::|..:.   |.:|..:...||||:
  Fly   577 -LRGQVIKVKATTRLDTHPCVITVEEMAAA---RHFIRTQSHQVPEQ---NRFALLQPELEINPK 634

Human   691 HPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLN 748
            ||:|: .|.:::|.:.|...| :|..||..|.:.:| |..|        .|||..::|
  Fly   635 HPIIK-KLNKLRESDKDLAQL-IAKQLFANAMVGAG-LAED--------PRMLLTNMN 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSP90B1NP_003290.1 SRT pseudosubstrate motif. /evidence=ECO:0000269|PubMed:39509507 42..44 0/1 (0%)
HATPase_Hsp90-like 83..275 CDD:340404 84/200 (42%)
HSP90 257..755 CDD:459703 142/505 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..323 0/34 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 750..803
Prevents secretion from ER 800..803
Trap1NP_477439.2 HtpG 65..689 CDD:440095 224/696 (32%)
Blue background indicates that the domain is not in the aligned region.

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