Protein Alignment NR2C1 and Hnf4

DIOPT Version :10

• Sequence 1: NP_003288.2
• Gene: NR2C1 / 7181
• HGNCID: 7971
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 124/556 - (22%)
• Similarity: 214/556 - (38%)
• Gaps: 170/556 - (30%)

Human    38 NTQGKQFILTNHDGSTPSKVILARQDSTPGKVFLTTPD------AAGVNQLFFTTPDLSAQHLQL 96
            |...:.|.|.|.:|:..|....:....:.....:.:|:      .:|.|.        |.|.||
  Fly   104 NQSSENFALCNGNGNAGSAGGGSASSGSNNNNSMFSPNNNLSGSGSGTNS--------SQQQLQ- 159

Human    97 LTDNSPDQGPNKVFDLCVVCGDKASGRHYGAVTCEGCKGFFKRSIRKNLVYSCRGSKDCIINKHH 161
              .....|.|.    :|.:|||:|:|:||||.:|:||||||:||:|||..|:||.:::|:::|..
  Fly   160 --QQQQQQSPT----VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDK 218

Human   162 RNRCQYCRLQRCIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLTATPTFVTD 226
            ||:|:||||::|...|||:::||.||.  .:|..::||
  Fly   219 RNQCRYCRLRKCFKAGMKKEAVQNERD--RISCRRTSN--------------------------- 254

Human   227 SESTRSTGLLDSGMFMNIHPSGVKTESAVLMTSDKAESCQGDLSTLANVVTSLANLGKTKDLSQN 291
            .:.....||                                          |:.:|.|.::.|:.
  Fly   255 DDPDPGNGL------------------------------------------SVISLVKAENESRQ 277

Human   292 SNEMSMIESLSNDDTSLCEFQEMQTNGDVSRAFDTLAKALNPGESTACQSSVAGMEGSVHLITGD 356
            |...:.:|...|:|.|..:|
  Fly   278 SKAGAAMEPNINEDLSNKQF--------------------------------------------- 297

Human   357 SSINYTEKEGPLLSDSHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSMHWALSIPSFQALGQEN 421
            :|||                               .:.||..:.|...:.||..||:|..|..::
  Fly   298 ASIN-------------------------------DVCESMKQQLLTLVEWAKQIPAFNELQLDD 331

Human   422 SISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHNSLQQDKMSTERRKLLMEHIFKLQEFC 486
            .::|::|:..|...|||::  :.|::..:|....||:......|.:.:....:.......:.|..
  Fly   332 QVALLRAHAGEHLLLGLSR--RSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELV 394

Human   487 NSMVKLCIDGYEYAYLKAIVLFSPDHPSLENMEQIEKFQEKAYVEFQDYITKTYPDDTYRLSRLL 551
            ..|..:.||..|:|.:||:|.|.|:...|....:|:..:.:.....:|||:....:...|...:|
  Fly   395 TVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEIL 459

Human   552 LRLPALRLMNATITEELFFKGLIGNIRIDSVIPHIL 587
            |.||.|:.:...:.|::.|..:.|...|||::..:|
  Fly   460 LILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEML 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR2C1	NP_003288.2	Required for interaction with KAT2B. /evidence=ECO:0000250	1..178		50/145 (34%)
		NR_DBD_TR2_like	108..194	CDD:143525	42/85 (49%)
		NR_LBD_TR2_like	368..589	CDD:132750	49/220 (22%)
		Required for interaction with NRIP1. /evidence=ECO:0000250	584..603		1/4 (25%)
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	41/74 (55%)
		NR_LBD_HNF4_like	264..494	CDD:132729	61/307 (20%)