DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment C3 and Tep2

DIOPT Version :9

Sequence 1:NP_000055.2 Gene:C3 / 718 HGNCID:1318 Length:1663 Species:Homo sapiens
Sequence 2:NP_523506.1 Gene:Tep2 / 34044 FlyBaseID:FBgn0041182 Length:1420 Species:Drosophila melanogaster


Alignment Length:1649 Identity:399/1649 - (24%)
Similarity:673/1649 - (40%) Gaps:382/1649 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    12 LLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVL 76
            ::|.:..|...:.:||::.|..||..|:..:|:..|.|.|...:.|:::. |...   .:::..|
  Fly     9 IILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNG-PSYN---ETKQIEL 69

Human    77 TPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLV-SLQSGY------LFIQT 134
            .|.:..  ||.|.:|            |..|.......:.|..||.. |.:..|      :|:||
  Fly    70 PPMSTQ--NVEFEVP------------KLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQT 120

Human   135 DKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQL-------GVLPLS 192
            ||..|.|...|.:||..::....|      ..||.|..:.:...:.:...||       ||....
  Fly   121 DKATYKPADLVQFRILFLDENTRP------AKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGE 179

Human   193 WDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITA 257
            ..:.|...:|.|||....:...::..|  |||.:||||.|||||: |.|...| .:|.::.||.|
  Fly   180 LQLSEQPVLGTWKISVSVDGDNRETKS--FEVDKYVLPKFEVIVD-TPKAVVI-ADKVIKATIRA 240

Human   258 RFLYGKKVEGTAFV----IFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPR--- 315
            ::.|||.|:|.|.|    .:| ..|:...:..:..|.|.: ||.|.|...   ::...|..:   
  Fly   241 KYTYGKPVKGKATVSMERSYG-YFGDLNANGNKQEKTIDV-DGKGHVEFD---IIHWAQRGQYLP 300

Human   316 --------AEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDL 372
                    .|:|.|.....:|||:||.       :|..|    .||:     .|::|:....|..
  Fly   301 PIKLFAVVTEELTGNKQNATATVVLHQ-------QRYSI----EPYE-----RPEHFEANKSFIY 349

Human   373 MVFVTNPDGSPA----------------------------------------------------Y 385
            .|.|.|.||||.                                                    |
  Fly   350 QVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSDSRYY 414

Human   386 RVPVAVQG-EDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTV 449
            |:..:..| |:|:.|:::.:       .|..|::||.|.|.|||..|.|                
  Fly   415 RIFASFDGSENTIGSISKFE-------PTPMSREPLKIQVNTKKPRLGE---------------- 456

Human   450 GNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDL 514
                                  .|:|    |......:.|:.|.|:.:|.::.:.......||..
  Fly   457 ----------------------QVSF----DVVSIEDLPYFVYTIVARGNVILSDYVDVPDGQKT 495

Human   515 VVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQ 579
            ..:..:.|...:|...:..||.:     ..::..:...:|.:.....|:.|    |......|.:
  Fly   496 YTVKFTPTFSMVPKATIYVYYVV-----NNDLQFEEKTIDFEKEFSNSIDV----SAPTNAKPSE 551

Human   580 QMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTP---GSGKDYAGVFSD 641
            ::.|:|:.|..:.|.|:.||:.|.:|...|.|:|..|::.:...... ||   |.|: |.|    
  Fly   552 EVKLRIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS-TPWMNGYGR-YPG---- 610

Human   642 AGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFS 706
                  .:||..|...|                          .||          ....|:..|
  Fly   611 ------QTSGLVTLTNA--------------------------NYP----------YNTGPLVMS 633

Human   707 CQRRTRFISLGEACKKVFLDCCNYITELRRQHA-RASHL--GLARSNLDEDIIAE--ENIVSRSE 766
                    .:.|..:..::....|...:|.... |.|.|  .|...||.|.::.:  :....|.|
  Fly   634 --------YVFEGSRHPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKE 690

Human   767 FPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVA-DPFEVTVMQDFF 830
            |||:|.:  |::.|  :....||.    :.|:||:|.:...|::...||.:. :|.::.|.|.||
  Fly   691 FPETWFF--ENVGE--EEFTLTKK----IPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFF 747

Human   831 IDLRLPYSVVRNEQVEIRAVLYNY------------RQNQE---LKVRVELLHNPAFCSLATTKR 880
            :...|||||.|.|.:.|..|::||            ..:||   .:...|:|..      |..:.
  Fly   748 VSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEK------AIDEV 806

Human   881 RHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRM--NKTVA 943
            |..:.||||..|..||.::|.|...|...:::.|.  .....|.:.:.|||.|||:.:  |:.|.
  Fly   807 RRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITAT--SALAGDAIHQKLKVEPEGVTLFENRAVF 869

Human   944 VRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPS 1008
            :...|...:.:.  ...|||    ::.||.:|     .::.:.|..:....:  :.|.:|:..|.
  Fly   870 INLKDQPEMSQS--LDADIP----NEVVPQSE-----FIEFSVVGDLLGPTL--QNLDNLVRMPY 921

Human  1009 GCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVK-- 1071
            |||||||:...|.::.:.||:.|.:.......|.:..||:   ||.::|.::....:::||.|  
  Fly   922 GCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEI---GYQRELTYKHDDGSYSAFGKSD 983

Human  1072 RAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNN 1136
            .:.||||||||::.|..|.....||.:|:...:.:|: .|||..|.|.|         :|.|.:|
  Fly   984 ASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLV-SKQKESGEFPE---------VGKLFDN 1038

Human  1137 -NEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG 1200
             |:..:|||:|||::..|.    .|.:.....:|.||..::..........|::|||..|| |:.
  Fly  1039 ANQNPLALTSFVLLAFFEN----HELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVAL-QLA 1098

Human  1201 RLKGP----LLNKFLTTAKDKN--RW---------EDPGKQLY------NVEATSYALLALLQLK 1244
              |.|    ::.|..:.|:.:|  .|         || |:..:      :||.|||.|||||:..
  Fly  1099 --KHPQSEKVIAKLESVARKENDRMWWSKATESTGED-GRVFHWKPRSNDVEITSYVLLALLEKD 1160

Human  1245 DFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQY-QKDAPDHQELNLDVSLQLPSRSSKIT 1308
            ..:...|:::||..||...||:.|||.|.:..|||.:: .|.......::::.|   .:..||.|
  Fly  1161 PAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFS---SAGESKNT 1222

Human  1309 HRIHWESASLLRSEE-TKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPE 1372
            .:::.|::.:|::.: .|.......||:|.|...:.:...|:...|::        |.:.|..|.
  Fly  1223 IKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEK--------KPSFKVTPT 1279

Human  1373 TEKRPQDAKNTMILEICTRY------RGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISK 1431
            .:..|   ...:|:::|..|      ..|:|:.|::::|::.:||..|:..|.:: ..||| :.:
  Fly  1280 VKDTP---NQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKI-QAVDR-VKR 1339

Human  1432 YELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPE 1496
            .|...:.|   |:::|.|.::..:..||..:..:...|...:|.:|.:|.||:.|...|.:|..:
  Fly  1340 VETKNSDS---TVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVK 1401

Human  1497 KEDGKLNKLCRDELCRCAE--ENC 1518
                  :.||  ::|..|:  |.|
  Fly  1402 ------SSLC--DICEGADCGEGC 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3NP_000055.2 A2M_N 129..224 CDD:280081 26/107 (24%)
A2M_N_2 458..604 CDD:285005 26/145 (18%)
ANATO 678..747 CDD:237984 10/71 (14%)
A2M 770..866 CDD:278630 30/111 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 954..973 4/18 (22%)
complement_C3_C4_C5 996..1282 CDD:239226 98/309 (32%)
A2M_comp 1051..1282 CDD:284982 81/254 (32%)
A2M_recep 1398..1493 CDD:284981 24/94 (26%)
NTR_complement_C3 1513..1661 CDD:239638 3/8 (38%)
Interaction with CFP/properdin. /evidence=ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604 1634..1659
Tep2NP_523506.1 A2M_N 115..209 CDD:280081 25/101 (25%)
A2M_N_2 445..576 CDD:285005 33/181 (18%)
A2M 694..782 CDD:278630 28/95 (29%)
A2M_2 909..1198 CDD:239227 98/311 (32%)
A2M_comp 961..1199 CDD:284982 81/258 (31%)
A2M_recep 1308..1398 CDD:284981 24/94 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149988
Domainoid 1 1.000 53 1.000 Domainoid score I11337
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
65.800

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