DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TPTE and Tpte2

DIOPT Version :9

Sequence 1:	NP_954870.3	Gene:	TPTE / 7179	HGNCID:	12023	Length:	551	Species:	Homo sapiens
Sequence 2:	XP_038950660.1	Gene:	Tpte2 / 364629	RGDID:	1305825	Length:	674	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	328/552 - (59%)
Similarity:	402/552 - (72%)	Gaps:	32/552 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    20 NDSPQTSEFKGATEEAPAKESPHTSEFKGAARVSP--------ISESV---------LARLSKFE 67
            |||   :..:|  :||.::.|..:|..|..:.||.        |||.:         |.::||..
  Rat   130 NDS---ALLRG--KEAASELSQVSSTMKTQSSVSTSILSTSDLISEEIQEEQINKCKLNQISKLY 189

Human    68 VEDAENV---ASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSI 129
            .|| |:|   .||.|.:||.||.:|||.||.:||:.|:.|||.|:..||..|:..:|||||||:|
  Rat   190 DED-EHVDIRESYWSTVKKFVHFLVSSVAFRIFGILLIFLDVFLVAIDLHATEKNIYIPLEYRAI 253

Human   130 SLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLL 194
            |||||||||:||||||:||.||:||||:.|.||..:|.:.:||.|:|..:|.:.||||||...||
  Rat   254 SLAIALFFLVDVLLRVYVEGRQRYFSDVLNTLDAVVIGVTVLVAVIYTLYDKQFLRNIPRLAVLL 318

Human   195 RLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSF 259
            |.|||:||:||..|.|||||||||.|:.||.|||||.:||||||||||||||||||||||||:||
  Rat   319 RPLRLLILVRILQLAHQKRQLEKLTRQLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESF 383

Human   260 YRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNE 324
            |||||||||||||.||.|||:||||||||:||||.||.||.||||||||||||.:|::|:||||:
  Rat   384 YRNPIKEVVRFLDTKHPNHYQVYNLCSERSYDPKRFHYRVRRIMIDDHNVPTLEEMLLFSKEVND 448

Human   325 WMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVKTPS 389
            |||||.||:||||||||..||||||||.||||||...||.|||:||||||||::|.|||||:|||
  Rat   449 WMAQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKASLYFFGERRTDKSNSSKFQGVETPS 513

Human   390 QKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVR----DLKIQIEMEKKVVFSTISLGK 450
            |.|||.||.::|..|...|||:::|.||.|.:|||....:    ||:|||.|.::.:||..:...
  Rat   514 QNRYVKYFEKLKTSYQLTLPPKKVLVIKRFTVYSIHGVGKGNGSDLEIQIMMWQETIFSCFNSKN 578

Human   451 CSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNEL 515
            |.:..::.|||::|:||:...|||||||:|...|||.|||:|.|:||.|||||.|||||||::||
  Rat   579 CMIFHDVETDKVIINVFNCPALYDDVKVKFLCPNLPKYYDDCPFFFWFHTSFIRNNRLYLPRSEL 643

Human   516 DNLHKQKARRIYPSDFAVEILFGEKMTSSDVV 547
            ||.||||..:||...||||:.|.|  .||.|:
  Rat   644 DNTHKQKTWKIYGPKFAVEVYFEE--ISSTVM 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPTE	NP_954870.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		8/26 (31%)
		PTP_VSP_TPTE	224..400	CDD:350360	141/175 (81%)
		PTEN_C2	409..539	CDD:402161	69/133 (52%)
Tpte2	XP_038950660.1	PTP_VSP_TPTE	348..524	CDD:350360	141/175 (81%)
Tpte2	XP_038950660.1	PTEN_C2	533..667	CDD:402161	69/133 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83693287
Domainoid	1	1.000	176	1.000	Domainoid score	I27634
eggNOG	1	0.900	-	-		E2759_KOG2283
HGNC	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	665	1.000	Inparanoid score	I9271
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG44910
OrthoDB	1	1.010	-	-		D142233at40674
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	1	1.000	-	-		otm52253
orthoMCL	1	0.900	-	-		OOG6_100936
Panther	1	1.100	-	-	O	PTHR12305
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X965
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810