Protein Alignment TPT1 and Tctp

DIOPT Version :10

• Sequence 1: NP_001273201.1
• Gene: TPT1 / 7178
• HGNCID: 12022
• Length: 197
• Species: Homo sapiens
• Sequence 2: NP_650048.1
• Gene: Tctp / 41341
• FlyBaseID: FBgn0037874
• Length: 172
• Species: Drosophila melanogaster
• Alignment Length: 177
• Identity: 88/177 - (49%)
• Similarity: 122/177 - (68%)
• Gaps: 10/177 - (5%)

Human     1 MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGEGTEST 65
            |.||:|:|:.||||:|.||:: :.|.:..||.||:::| :|: |..|.|.|||||..: |||:.|
  Fly     1 MKIYKDIITGDEMFADTYKMK-LVDDVIYEVYGKLITR-QGD-DIKLEGANASAEEAD-EGTDIT 61

Human    66 VITGVDIVMNHHLQET-SF-TKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAEQIKHILAN 128
            ..:|||:|:||.|.|. :| .|::|..|:|||||.:..||||:.|::|..|.|...:.:|.||..
  Fly    62 SESGVDVVLNHRLTECFAFGDKKSYTLYLKDYMKKVLAKLEEKSPDQVDIFKTNMNKAMKDILGR 126

Human   129 FKNYQFFIGENMNPDGMVALLDYRE---DGVTPYMIFFKDGLEMEKC 172
            ||..|||.||:|:.||||||::|||   |.| |.::|||.|||.|||
  Fly   127 FKELQFFTGESMDCDGMVALVEYREINGDSV-PVLMFFKHGLEEEKC 172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPT1	NP_001273201.1	TCTP	1..167	CDD:459957	82/170 (48%)
		Required for reduction of TSC22D1 protein stability. /evidence=ECO:0000269|PubMed:18325344	70..172		54/106 (51%)
Tctp	NP_650048.1	TCTP	1..167	CDD:459957	82/170 (48%)