DRSC/TRiP Functional Genomics Resources

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Protein Alignment TPO and cysu

DIOPT Version :9

Sequence 1:XP_024308853.1 Gene:TPO / 7173 HGNCID:12015 Length:947 Species:Homo sapiens
Sequence 2:NP_650627.1 Gene:cysu / 42100 FlyBaseID:FBgn0038511 Length:753 Species:Drosophila melanogaster


Alignment Length:694 Identity:227/694 - (32%)
Similarity:337/694 - (48%) Gaps:123/694 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   105 IMETSIQAMKRKVNLKTQQSQH--PTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPIT 167
            :::.||| :.|...|..::.:.  ||...|:.|:..:     |.|:....:    |...|||...
  Fly   105 LLDISIQ-LARTYGLSYEEIEKGLPTIDTSKTLIREV-----CPPFFAGVE----CRPGKYRRFD 159

Human   168 GACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVV 232
            |.|||.:||.|||:|....|.:.|:|.||.:.||     ....|..||..|.|:|        .:
  Fly   160 GLCNNIEHPTWGAANAPFQRLIGPLYSDGINAPR-----ISVTGRDLPFSRVVSR--------TM 211

Human   233 TDDDRYSD-----LLMAWGQYIDHDIAFTPQSTSKAAFGGGAD----------CQMTCENQNP-C 281
            ..||.:.|     :::||||::|||...|         |...|          |:.....::| |
  Fly   212 HPDDGFHDHAGTVMVIAWGQFMDHDFTLT---------GTPLDPINRNDPEECCKRPLHLKHPYC 267

Human   282 FPIQLPEE--ARPAAGTACLPFYRS----SAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAST 340
            ..|::|::  ........|:.|.|.    ...|..|.             |||.|.||..:||:|
  Fly   268 NEIRIPDDDYFYRLFNVKCIDFVRGFPSPRPGCKLGS-------------RQQFNTLTGVIDANT 319

Human   341 VYGSSPALERQLRNWTSAEGLLRVHARLRDSG-RAYLPFVPPRAPAACAPEPGIPGE--TRGP-- 400
            |||...:..|:||  |...||:|::...::.| :..||.           :..||.|  || |  
  Fly   320 VYGVKESFARKLR--TGYGGLMRMNPVFQEYGLKDLLPL-----------KLDIPDEGCTR-PNK 370

Human   401 ---CFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITL 462
               ||..|:.|.:|...||.:|||..|||||||.||..:|.||..:.::||||::..|:.|.:|.
  Fly   371 SMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINIAIVQHVTF 435

Human   463 RDYIPRILGPEAFQQY------VGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQ 521
            .:::|.:||.|..:::      .|.::|||||.||.:.:.|:.|||||||:.:...|.|..   :
  Fly   436 NEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAVERWS---K 497

Human   522 EHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSS-TL 585
            .|..:....|......|:.|.|.|.||....||:.:.|  |..|..:.:|:|..||....:. .:
  Fly   498 AHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVA--QAMDDSITQEVTNHLFKKEGARFGM 560

Human   586 DLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGG 650
            ||.|.|:||||:.|:|||.|:|:|||||...|..::..::.:.:|. :...:::||.:||:|.||
  Fly   561 DLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPNETVL-RYGSIFEHPADIDLWSGG 624

Human   651 LAENFLPRARTGPLFACLIGKQMKALRDGDWFWWE---NSHVFTDAQRRELEKHSLSRVICDNTG 712
            ::|..||.:..||.|||:|..||..||.||.||:|   ....||..|.:|:.|..|||:|||||.
  Fly   625 VSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTD 689

Human   713 LTRVPMDAFQVGKFP---EDFE-----SCDS--ITGMNLEAWRE 746
            |    :|..|:  :|   .|.|     .|.|  |..::|..|.:
  Fly   690 L----IDTVQI--YPMVLPDHEINPRVPCKSGIIPSIDLTKWAD 727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TPOXP_024308853.1 thyroid_peroxidase 179..746 CDD:188657 205/616 (33%)
CCP 754..807 CDD:153056
cysuNP_650627.1 An_peroxidase 155..692 CDD:281139 204/595 (34%)
peroxinectin_like 305..687 CDD:188655 152/401 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 304 1.000 Inparanoid score I2660
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D276568at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.870

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