Protein Alignment TPO and Irc

DIOPT Version :9

• Sequence 1: XP_024308853.1
• Gene: TPO / 7173
• HGNCID: 12015
• Length: 947
• Species: Homo sapiens
• Sequence 2: NP_001262653.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Alignment Length: 795
• Identity: 195/795 - (24%)
• Similarity: 303/795 - (38%)
• Gaps: 240/795 - (30%)

Human    43 WGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIME 107
            |.:..|:.:.|| ...|||.|..:.:.:   ..|.|.||.||||  ..||
  Fly    42 WLQYVETALDSV-NRQKRLEDNLLGSDI---TVKNGSLSHAQLL--DTLP--------------- 85

Human   108 TSIQAMK-RKVNLKTQQSQHPTDALSEDLLSIIANMSGCLP----------YM----------LP 151
             |:.:.| .|:.||..:|            |::...|.|||          |:          |.
  Fly    86 -SLASKKDNKLALKILKS------------SLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLR 137

Human   152 PKCPNTCLANK-----YRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNG 211
            .:|.|:...|:     :|.:.|:.:                     |.:||           |..
  Fly   138 TECENSLKGNREGHYAFRRLLGSSH---------------------YRNGF-----------YQM 170

Human   212 FPLPPVREVTRHVIQVSNEVVTDD----------DRYSDL-LMAWGQYIDHDIAFTPQSTSKAAF 265
            ||....||.......:|.|:...|          :..|:| |..|.|:::||:: .|.|.|   .
  Fly   171 FPNSGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDLS-KPVSQS---M 231

Human   266 GGGADCQMTCENQNPCFPIQL-PEEARPAAG------------TACLPFYRSSAA---CGTGDQG 314
            ..||..:....:|     |.| |....||..            .:||.:.||:.|   |..|  |
  Fly   232 SNGAPIECCSRDQ-----INLQPRHHHPACAPILYQPGGKYDVPSCLNYVRSALAVADCNFG--G 289

Human   315 ALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPF- 378
            |           :|:|..|..||.|.:||.:.|.||:||  ....||||...| .:...|.||.
  Fly   290 A-----------EQLNQATGSLDLSQLYGFTAAAERKLR--VLEGGLLRSTPR-GEFDNALLPIA 340

Human   379 VPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSAD 443
            .....|:.||  ....|:  |.||.|||.|.:..|....::|:::|.||::||.||..|..||.:
  Fly   341 TDTEGPSFCA--RATIGD--GTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDE 401

Human   444 AVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHAT 508
            .::|.|:.|...:::.:.:.:::|.:||    |:...............|||.|:.||.||..:.
  Fly   402 KLFQAAKAVNVDIYRRVVIEEWLPEVLG----QKMSSEIRRKQPNRALEVSNEFAVAAIRFYFSM 462

Human   509 IHPLVRRLDAS---------------FQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARP 558
            :...:..|...               .:|.|......|.:..:.|
  Fly   463 LPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKP-------------------- 507

Human   559 AKLQVQDQLMNEELTERLFVLSNSSTL---------------------DLASINLQRGRDHGLPG 602
             |||...|.:|..|..    |.|..|:                     |:.:.::||||||||..
  Fly   508 -KLQYTSQKLNNILES----LLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLP 567

Human   603 YNEWREFCGLPR-LETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFA 666
            |..:.|.|.|.| :|:..|....|.| .|.||:..:|....::|:.:||::||.: ....||.|:
  Fly   568 YYRYLESCVLSRPVESWKDFEHFIPS-DVLDKLKTIYASWADVDLIVGGISENPV-HGSIGPTFS 630

Human   667 CLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSL----------SRVICDNTGLTRVPMDAF 721
            |:|.:|.             .||....|::.::||:.          ::::|.|:||:.||.:.|
  Fly   631 CIISEQF-------------VHVLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIF 682

Human   722 QVGKFPEDFESCDSI 736
            |:........||:.:
  Fly   683 QLPSARNQMVSCEDV 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPO	XP_024308853.1	thyroid_peroxidase	179..746	CDD:188657	159/633 (25%)
		CCP	754..807	CDD:153056
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	152/625 (24%)
		An_peroxidase_like	290..637	CDD:265428	106/395 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820