Protein Alignment TPM4 and TPM1

DIOPT Version :10

• Sequence 1: NP_001138632.1
• Gene: TPM4 / 7171
• HGNCID: 12013
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_014320.1
• Gene: TPM1 / 855645
• SGDID: S000005023
• Length: 199
• Species: Saccharomyces cerevisiae
• Alignment Length: 207
• Identity: 53/207 - (25%)
• Similarity: 109/207 - (52%)
• Gaps: 8/207 - (3%)

Human     1 MEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLK 65
            |:.|::|:..|||:.|:..::.|:.:...|..|.:..:.|.::..|..|.:..|||::|....|.
Yeast     1 MDKIREKLSNLKLEAESWQEKYEELKEKNKDLEQENVEKENQIKSLTVKNQQLEDEIEKLEAGLS 65

Human    66 DAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVI 130
            |:::    ||:...:.|..:.:|..:...:|||:::.:..||.:.|..|::......::...|
Yeast    66 DSKQ----TEQDNVEKENQIKSLTVKNHQLEEEIEKLEAELAESKQLSEDSHHLQSNNDNFSK-- 124

Human   131 ENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEE 195
            :|:.:  ||.:|..:.:|||......|:|.|.:::.|::..||.:.|..|.:.|...:|..|.::
Yeast   125 KNQQL--EEDLEESDTKLKETTEKLRESDLKADQLERRVAALEEQREEWERKNEELTVKYEDAKK 187

Human   196 ELKNVTNNLKSL 207
            ||..:..:|::|
Yeast   188 ELDEIAASLENL 199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPM4	NP_001138632.1	Tropomyosin	48..282	CDD:459736	41/160 (26%)
TPM1	NP_014320.1	Tropomyosin_1	7..186	CDD:403808	47/186 (25%)