Protein Alignment TPM3 and Tm1

DIOPT Version :10

• Sequence 1: NP_689476.2
• Gene: TPM3 / 7170
• HGNCID: 12012
• Length: 285
• Species: Homo sapiens
• Sequence 2: NP_732006.2
• Gene: Tm1 / 41852
• FlyBaseID: FBgn0003721
• Length: 711
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 148/336 - (44%)
• Similarity: 209/336 - (62%)
• Gaps: 60/336 - (17%)

Human     7 KKMQMLKLDKENALDRAEQAEAEQKQA--EERSK------QLEDELA------AMQKKLKGTEDE 57
            ||.:..|.::....|::|:::.::|.:  :||||      |..|.||      |:.:.:...:|:
  Fly   372 KKKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436

Human    58 LDKYSE--ALKDAQEKLEL-AEKKA-------AD------------------------------- 81
            .::.:|  .|:...|..|: ||::|       ||
  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501

Human    82 -----AEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEK 141
                 ||:|||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::|||||.|||:
  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566

Human   142 MELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLK 206
            |:..|.|||||:.:|||||:||:||||||.::|.||||.|||||..|:|..||||||:.|.||||
  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631

Human   207 SLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAI 271
            |||...||.:|:|::|:.:||.|..:|||||.|||||||||.||:|.:|.|||:|..:|.:||.|
  Fly   632 SLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDI 696

Human   272 SEELDHALNDM 282
            .::||.|..::
  Fly   697 GDDLDTAFVEL 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPM3	NP_689476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..44		9/35 (26%)
		Tropomyosin	49..283	CDD:459736	133/280 (48%)
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:403808
		Tropomyosin	507..708	CDD:459736	123/201 (61%)