DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TPM2 and Tm2

DIOPT Version :9

Sequence 1:	XP_016870576.1	Gene:	TPM2 / 7169	HGNCID:	12011	Length:	303	Species:	Homo sapiens
Sequence 2:	NP_001262592.1	Gene:	Tm2 / 41853	FlyBaseID:	FBgn0004117	Length:	284	Species:	Drosophila melanogaster

Alignment Length:	213	Identity:	101/213 - (47%)
Similarity:	149/213 - (69%)	Gaps:	0/213 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVK 65
            |||||||||.:||:|:||||:|:..|...|.|..|..:|.||.:.|:||....|.::....|.::
  Fly     1 MDAIKKKMQAMKLEKDNAIDKADTCENQAKDANSRADKLNEEVRDLEKKFVQVEIDLVTAKEQLE 65

Human    66 EAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVI 130
            :|..:||:.||..|..|::||:.||::|.:||:|::::||..||.|||.||.::|||:.|..||:
  Fly    66 KANTELEEKEKLLTATESEVATQNRKVQQIEEDLEKSEERSTTAQQKLLEATQSADENNRMCKVL 130

Human   131 ENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEE 195
            |||:.:|||:|:....|||||:.:|||:|.|.:||:|||..:|.|||.:|:|....||:..:|||
  Fly   131 ENRSQQDEERMDQLTNQLKEARMLAEDADTKSDEVSRKLAFVEDELEVAEDRVRSGESKIMELEE 195

Human   196 ELRTMDQALKSLMASEEE 213
            ||:.:..:||||..|||:
  Fly   196 ELKVVGNSLKSLEVSEEK 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPM2	XP_016870576.1	None
Tm2	NP_001262592.1	Tropomyosin	48..281	CDD:395200	76/166 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147727
Domainoid	1	1.000	247	1.000	Domainoid score	I2154
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48449
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8448
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.720