DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TPM2 and Tm1

DIOPT Version :9

Sequence 1:	XP_016870576.1	Gene:	TPM2 / 7169	HGNCID:	12011	Length:	303	Species:	Homo sapiens
Sequence 2:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster

Alignment Length:	268	Identity:	101/268 - (37%)
Similarity:	149/268 - (55%)	Gaps:	60/268 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     5 KKKMQ----MLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKG---------TEDE 56
            |||.:    ..|.||....||.::: :.||:...|...:|:...:|...|..         .:|:
  Fly   373 KKKREKGERSEKSDKSEKSDRKKKS-SGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436

Human    57 VEKYSESVK-----EAQEKLEQAEKK-------------------ATD----------------- 80
            ..:.:|..|     ||.|.:.:.|.:                   ::|
  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501

Human    81 -----AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEK 140
                 ||::||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::||||:.|||:
  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566

Human   141 MELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALK 205
            |:..|.|||||:.:||::|:||:||||||.::|.:|||:|||||..|::..:||||||.:...||
  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631

Human   206 SLMASEEE 213
            ||..|||:
  Fly   632 SLEVSEEK 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPM2	XP_016870576.1	None
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	72/123 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147726
Domainoid	1	1.000	247	1.000	Domainoid score	I2154
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2689
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8448
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760