DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TPM2 and lev-11

DIOPT Version :9

Sequence 1:	XP_016870576.1	Gene:	TPM2 / 7169	HGNCID:	12011	Length:	303	Species:	Homo sapiens
Sequence 2:	NP_001021695.1	Gene:	lev-11 / 173319	WormBaseID:	WBGene00002978	Length:	284	Species:	Caenorhabditis elegans

Alignment Length:	215	Identity:	115/215 - (53%)
Similarity:	161/215 - (74%)	Gaps:	0/215 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVK 65
            |||||||||.:|::|:||:|||:.||...:|..::.:::|||.:..|||:..|.|:::|..|.:.
Worm     1 MDAIKKKMQAMKIEKDNALDRADAAEEKVRQITEKLERVEEELRDTQKKMTQTGDDLDKAQEDLS 65

Human    66 EAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVI 130
            .|..|||:.||...:|||:|||||||:.|:||||:||:|||..|.:|||||....|||||..||:
Worm    66 AATSKLEEKEKTVQEAEAEVASLNRRMTLLEEELERAEERLKIATEKLEEATHNVDESERVRKVM 130

Human   131 ENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEE 195
            |||:::|||:....|.|||||:.:||::||||:||||||.::|.:|||:|||||..|::..:|||
Worm   131 ENRSLQDEERANTVEAQLKEAQLLAEEADRKYDEVARKLAMVEADLERAEERAEAGENKIVELEE 195

Human   196 ELRTMDQALKSLMASEEEVV 215
            |||.:...||||..|||:.:
Worm   196 ELRVVGNNLKSLEVSEEKAL 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPM2	XP_016870576.1	None
lev-11	NP_001021695.1	Tropomyosin	48..282	CDD:278679	92/168 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161454680
Domainoid	1	1.000	268	1.000	Domainoid score	I1100
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	316	1.000	Inparanoid score	I1734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48449
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		otm15181
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910