DRSC/TRiP Functional Genomics Resources

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Protein Alignment TPH1 and Hn

DIOPT Version :10

Sequence 1:NP_004170.1 Gene:TPH1 / 7166 HGNCID:12008 Length:444 Species:Homo sapiens
Sequence 2:NP_523963.2 Gene:Hn / 38871 FlyBaseID:FBgn0001208 Length:452 Species:Drosophila melanogaster


Alignment Length:431 Identity:232/431 - (53%)
Similarity:312/431 - (72%) Gaps:14/431 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    14 ERGRASLIFSLKN---EVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLND 75
            |.....|:||.|:   ..|.|...|.||::..:||:|||||.|.|... :|.||:.|.....|..
  Fly    28 EARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGALGK 91

Human    76 IFHLLK---SHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137
            ....:|   |:.|::|.:..||.|       .|||||::|.|||..||::|.||||||||||||.
  Fly    92 AIEDVKEQCSYFNIISRDYKDNAT-------AVPWFPRRIRDLDRFANQILSYGSELDADHPGFT 149

Human   138 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSK 202
            |..||||||||||:|.|||||:|:|.|::|:|||:|||.:|:.|.|||.|||||||....|||..
  Fly   150 DPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVD 214

Human   203 YCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPE 267
            .||:|||||||||||||||::.|||::|||||.||.||||:||||||||.|||:||.|.|.||||
  Fly   215 NCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPE 279

Human   268 PDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGA 332
            ||.||||:|||||.|:|:|||||||||||||||.::.::||:|.::||||:|:|:|:|:|:.:||
  Fly   280 PDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGA 344

Human   333 GLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPF 397
            |||||..||::.|:...::|.|:|::|...:..||.||.:|:|::|||.||||..:|..:|.|||
  Fly   345 GLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPF 409

Human   398 GVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKV 438
            ||:||.||:|:::|.....|::.|:.:..:..::.:|:||:
  Fly   410 GVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TPH1NP_004170.1 Trp_5_monoox 3..439 CDD:130337 232/431 (54%)
HnNP_523963.2 Phe4hydrox_tetr 15..451 CDD:130335 232/431 (54%)

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