DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TPH1 and ple

DIOPT Version :9

Sequence 1:	NP_004170.1	Gene:	TPH1 / 7166	HGNCID:	12008	Length:	444	Species:	Homo sapiens
Sequence 2:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	191/436 - (43%)
Similarity:	289/436 - (66%)	Gaps:	8/436 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     7 ENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINRE 71
            |:.|.......|:|:..||..:..|.:.||..:..|..:.|:|||:|:....:.::.:..|:.|.
  Fly   148 ESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRG 212

Human    72 QLNDIFHLLKSHTNVLSVNL--PDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHP 134
            .|..:...|:...:..|:||  .:|..:|      .|||||..|:||:|.:.:..|..:||.:||
  Fly   213 NLLQLIRSLRQSGSFSSMNLMADNNLNVK------APWFPKHASELDNCNHLMTKYEPDLDMNHP 271

Human   135 GFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPL 199
            ||.|.|||:|||..|::|..||:|||||.:::::.|:|||.:||:.:..|.|.|||.||......
  Fly   272 GFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQK 336

Human   200 LSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFY 264
            |.....:.|..:|||:::|:||::.||||:||.||.|:.||||:.||||:|..||||||.:.|::
  Fly   337 LQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYH 401

Human   265 TPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRV 329
            |||||:.||||||:||||:||||||||||||||||||:|.::||:|.|:|||||||||:.||::.
  Fly   402 TPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKA 466

Human   330 FGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIK 394
            :|||||||..||.||:|...:.:.|:|..|..|......:|.:|:|:|||||||:|.|.:..|:.
  Fly   467 YGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMS 531

Human   395 RPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSR 440
            |||.|::||:|..:::|.....:.:.::::..::..:::|::|:.|
  Fly   532 RPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRR 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPH1	NP_004170.1	Trp_5_monoox	3..439	CDD:130337	190/433 (44%)
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	190/433 (44%)
		ACT	130..234	CDD:298841	22/85 (26%)
		Biopterin_H	243..573	CDD:278766	165/329 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920