Protein Alignment TPH1 and Trhn

DIOPT Version :10

• Sequence 1: NP_004170.1
• Gene: TPH1 / 7166
• HGNCID: 12008
• Length: 444
• Species: Homo sapiens
• Sequence 2: NP_612080.1
• Gene: Trhn / 38121
• FlyBaseID: FBgn0035187
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 452
• Identity: 260/452 - (57%)
• Similarity: 345/452 - (76%)
• Gaps: 24/452 - (5%)

Human     3 EDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCD 67
            :||  .:.|| ...|.|:||:|:|:||.|.:||::|||..:|:||:|....:...::.::.||.:
  Fly    67 QDN--GRQHS-PGERISIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMATNQADVLVDVE 128

Human    68 INREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVP--------------WFPKKISDLDHC 118
            .::.:|:.:..:|  :..|.|||..   ::...|:...|              |||:||||||..
  Fly   129 CDQRRLDQVVKML--NREVASVNYT---SVNTQGLARAPSLSACSSFDFGDMVWFPRKISDLDKA 188

Human   119 ANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNK 183
            .| |||||||||||||||||.||||||:.|:.:|.|:|||:|||:|::|.||:|||||||.||::
  Fly   189 QN-VLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHR 252

Human   184 LYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFR 248
            ||..||..||:.|.|.|.|||||||||:|||:|||.:||.:|||.:|||||||||||||||||||
  Fly   253 LYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFR 317

Human   249 VFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYF 313
            |||||||:|||||||||||||.|||||||:||||..|||||||||||||||||:..::||||.||
  Fly   318 VFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYF 382

Human   314 FTVEFGLCKQ-DGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSE 377
            |||||||||| |...:|:|||||||::||:||::...|:|.|||::||:|||:||::|:.|:.::
  Fly   383 FTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTD 447

Human   378 SFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVS 439
            |||:|||:||.|.::|:|||||:|||||.|:::|.:.|.||:.::||:.||.:|..||.|:|
  Fly   448 SFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKIS 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPH1	NP_004170.1	Trp_5_monoox	3..439	CDD:130337	259/450 (58%)
Trhn	NP_612080.1	Trp_5_monoox	34..509	CDD:130337	259/450 (58%)