DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TPD52L2 and CG5174

DIOPT Version :9

Sequence 1:	NP_955392.1	Gene:	TPD52L2 / 7165	HGNCID:	12007	Length:	229	Species:	Homo sapiens
Sequence 2:	NP_001246407.1	Gene:	CG5174 / 37117	FlyBaseID:	FBgn0034345	Length:	369	Species:	Drosophila melanogaster

Alignment Length:	210	Identity:	57/210 - (27%)
Similarity:	103/210 - (49%)	Gaps:	33/210 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     2 DSAGQDINLNSPNKGLLSDSMTDV-----PVDTGVAARTPAVEGLTEAEEEELR-----AELTKV 56
            |:..:.:|:...::|...|:..::     |.::..:|...|.......||:|.|     .||.:|
  Fly   133 DNYKRFLNIGHRSRGTKFDNTANLSEPASPANSVASAEIAAEFAALSVEEKEQRRAEWSQELARV 197

Human    57 EEEIVTLRQVLAAKERHCGELKRRLGLSTLGELKQNLSRSWHDVQVSSAYVKTSEKLGEWNEKVT 121
            ||||.|||.|||:|.||..:|||:||::...|:..::::...:::.|:.|....:.:|.:.:.|.
  Fly   198 EEEINTLRTVLASKTRHASDLKRKLGITVWKEVTDDVNQGLKNLKESTVYQSVEQSVGTFTKTVY 262

Human   122 QSDLYKKTQETLSQAGQKTSAALSTVGSAISRKLGDMRAHPFSHSFSSYSIRHSISMPAMRNSAT 186
            ::.||::|:..|...|:||::...::.|.||.||..                       |:||.:
  Fly   263 EAPLYQRTESVLKSTGEKTASVFGSITSGISSKLSQ-----------------------MKNSES 304

Human   187 FKSFEDRVGTIKSKV 201
            .:|.|..||:....|
  Fly   305 MRSIEASVGSAYENV 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TPD52L2	NP_955392.1	TPD52	<55..220	CDD:282107	44/147 (30%)
CG5174	NP_001246407.1	TPD52	158..314	CDD:282107	51/178 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146210
Domainoid	1	1.000	54	1.000	Domainoid score	I11225
eggNOG	1	0.900	-	-		E1_KOG4010
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I5001
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1225782at2759
OrthoFinder	1	1.000	-	-		FOG0000981
OrthoInspector	1	1.000	-	-		otm41657
orthoMCL	1	0.900	-	-		OOG6_107924
Panther	1	1.100	-	-	LDO	PTHR19307
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4903
SonicParanoid	1	1.000	-	-		X5007
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790