Protein Alignment TP53 and tp53

DIOPT Version :10

• Sequence 1: NP_000537.3
• Gene: TP53 / 7157
• HGNCID: 11998
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_001001903.1
• Gene: tp53 / 431679
• XenbaseID: XB-GENE-484286
• Length: 362
• Species: Xenopus tropicalis
• Alignment Length: 404
• Identity: 204/404 - (50%)
• Similarity: 247/404 - (61%)
• Gaps: 56/404 - (13%)

Human     3 EPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQW--FTEDP-GPD--- 61
            ||.|:..:|||||||||.|||.|||             |.|......:|.:  |:|.| .||
 Frog     2 EPSSETGMEPPLSQETFEDLWSLLP-------------DPLQTGTGQMENFAEFSEYPLAPDMTV 53

Human    62 -EAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCT 125
             :...|....|.|.                   ||:|||.:.|.||||.:|.|..:|||||||||
 Frog    54 LQEGLMGNTVPTVT-------------------SSAVPSTEDYAGSYGLKLEFQQNGTAKSVTCT 99

Human   126 YSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSD-SDGLA 189
            ||..|||:|||||||||:.:.|:..||.|:.:||.|:||:|:|:.|||:|||||||..: .|..|
 Frog   100 YSTDLNKLFCQLAKTCPLLVRVERPPPLGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGDDPA 164

Human   190 PPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTI 254
            ||.||:|||||.:..|::|..|.||||.||||.|:||::|||:.|||||||||||||||||||||
 Frog   165 PPSHLMRVEGNSKAYYMEDVGTGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTI 229

Human   255 ITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPK 319
            ||||...|.||||..|||||||||||||||||:|..||    ..|.|.. ||.|.:..||.|...
 Frog   230 ITLESPEGLLLGRRCFEVRVCACPGRDRRTEEDNCTKK----RGLKPNG-KRELSHPPSSDPPLP 289

Human   320 KKPL----DGEYFTLQIRGRERFEMFRELNEALELKDA-QAGKEPGGSRAHSSHLKSKKGQSTSR 379
            ||.|    |.|.|||.|:||.|:||.::||:||||::: ...|.....|.....:|.|||
 Frog   290 KKRLVEEDDEETFTLLIKGRSRYEMIKKLNDALELQESLDQQKLSIKCRKCRDEIKPKKG----- 349

Human   380 HKKLMFKTEGPDSD 393
             |||:.|.|..||:
 Frog   350 -KKLLVKDELQDSE 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TP53	NP_000537.3	Interaction with CCAR2. /evidence=ECO:0000269|PubMed:25732823	1..320		171/324 (53%)
		Interaction with HRMT1L2. /evidence=ECO:0000269|PubMed:15186775	1..83		29/86 (34%)
		Transcription activation (acidic)	1..44		19/40 (48%)
		P53_TAD	6..30	CDD:462520	16/23 (70%)
		TADI	17..25		6/7 (86%)
		TAD2	35..59	CDD:375947	6/26 (23%)
		TADII	48..56		2/9 (22%)
		Disordered. /evidence=ECO:0000269|PubMed:31953488	50..96		10/52 (19%)
		Interaction with WWOX	66..110		13/43 (30%)
		Interaction with HIPK1. /evidence=ECO:0000250	100..370		159/275 (58%)
		Required for interaction with ZNF385A. /evidence=ECO:0000269|PubMed:17719541	100..300		129/200 (65%)
		P53	109..288	CDD:176262	121/179 (68%)
		Required for interaction with FBXO42. /evidence=ECO:0000269|PubMed:19509332	113..236		74/123 (60%)
		Interaction with AXIN1. /evidence=ECO:0000250	116..292		120/176 (68%)
		Interaction with the 53BP2 SH3 domain	241..248		6/6 (100%)
		Interaction with E4F1. /evidence=ECO:0000269|PubMed:10644996	256..294		28/37 (76%)
		Interaction with DNA	273..280		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..325		19/46 (41%)
		Interaction with CARM1. /evidence=ECO:0000269|PubMed:15186775	300..393		39/97 (40%)
		Bipartite nuclear localization signal	305..321		6/15 (40%)
		Interaction with HIPK2	319..360		21/45 (47%)
		P53_tetramer	319..358	CDD:462238	20/43 (47%)
		Oligomerization	325..356		16/31 (52%)
		Nuclear export signal	339..350		6/10 (60%)
		Disordered. /evidence=ECO:0000269|PubMed:31953488, ECO:0000269|PubMed:36108750	351..393		12/42 (29%)
		Interaction with USP7	359..363		0/3 (0%)
		Basic (repression of DNA-binding)	368..387		7/18 (39%)
		[KR]-[STA]-K motif	370..372		1/1 (100%)
		Interaction with MORN3. /evidence=ECO:0000269|PubMed:29681526	374..393		7/18 (39%)
tp53	NP_001001903.1	P53_TAD	5..28	CDD:462520	16/35 (46%)
		P53	84..264	CDD:176262	121/179 (68%)
		P53_tetramer	290..332	CDD:462238	20/41 (49%)