Protein Alignment TP53 and tp53

DIOPT Version :10

• Sequence 1: NP_000537.3
• Gene: TP53 / 7157
• HGNCID: 11998
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_001258749.1
• Gene: tp53 / 30590
• ZFINID: ZDB-GENE-990415-270
• Length: 374
• Species: Danio rerio
• Alignment Length: 397
• Identity: 199/397 - (50%)
• Similarity: 243/397 - (61%)
• Gaps: 46/397 - (11%)

Human    15 SQETFSDLWKLLPENNVLSPLPS------QAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPV 73
            ||| |::||    |.|::|..|.      ..::|....|...:..|.|:. .:|.|: |...||
Zfish     6 SQE-FAELW----EKNLISIQPPGGGSCWDIINDEEYLPGSFDPNFFENV-LEEQPQ-PSTLPP- 62

Human    74 APAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLA 138
                                :|:||....|.|.:||||.|..|||||||||||||.|||:|||||
Zfish    63 --------------------TSTVPETSDYPGDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLA 107

Human   139 KTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRV 203
            ||||||:.||..||.|:.|||.||||:|:|:.|||||||||||..|.|.|||..||||||||.|.
Zfish   108 KTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPHHERTPDGDNLAPAGHLIRVEGNQRA 172

Human   204 EYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRN 268
            .|.:|..|.||||.||||.|::|::.||:..||||||||||||||||||||||||...|.||||.
Zfish   173 NYREDNITLRHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRR 237

Human   269 SFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGS-TKRALPNNTSSS---PQPKKK----PLDG 325
            ||||||||||||||:|||.|.:|..|........: |||:|...:||:   |:..||    ..|.
Zfish   238 SFEVRVCACPGRDRKTEESNFKKDQETKTMAKTTTGTKRSLVKESSSATLRPEGSKKAKGSSSDE 302

Human   326 EYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTS---RHKKLMFKT 387
            |.||||:|||||:|:.::||::|||.|.....:....|........|:.:.:|   :.||||.|.
Zfish   303 EIFTLQVRGRERYEILKKLNDSLELSDVVPASDAEKYRQKFMTKNKKENRESSEPKQGKKLMVKD 367

Human   388 EG-PDSD 393
            || .|||
Zfish   368 EGRSDSD 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TP53	NP_000537.3	Interaction with CCAR2. /evidence=ECO:0000269|PubMed:25732823	1..320		166/314 (53%)
		Interaction with HRMT1L2. /evidence=ECO:0000269|PubMed:15186775	1..83		19/73 (26%)
		Transcription activation (acidic)	1..44		11/34 (32%)
		P53_TAD	6..30	CDD:462520	7/14 (50%)
		TADI	17..25		4/7 (57%)
		TAD2	35..59	CDD:375947	5/29 (17%)
		TADII	48..56		1/7 (14%)
		Disordered. /evidence=ECO:0000269|PubMed:31953488	50..96		7/45 (16%)
		Interaction with WWOX	66..110		9/43 (21%)
		Interaction with HIPK1. /evidence=ECO:0000250	100..370		165/277 (60%)
		Required for interaction with ZNF385A. /evidence=ECO:0000269|PubMed:17719541	100..300		137/199 (69%)
		P53	109..288	CDD:176262	131/178 (74%)
		Required for interaction with FBXO42. /evidence=ECO:0000269|PubMed:19509332	113..236		82/122 (67%)
		Interaction with AXIN1. /evidence=ECO:0000250	116..292		128/175 (73%)
		Interaction with the 53BP2 SH3 domain	241..248		6/6 (100%)
		Interaction with E4F1. /evidence=ECO:0000269|PubMed:10644996	256..294		27/37 (73%)
		Interaction with DNA	273..280		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..325		16/50 (32%)
		Interaction with CARM1. /evidence=ECO:0000269|PubMed:15186775	300..393		38/104 (37%)
		Bipartite nuclear localization signal	305..321		6/18 (33%)
		Interaction with HIPK2	319..360		20/44 (45%)
		P53_tetramer	319..358	CDD:462238	20/42 (48%)
		Oligomerization	325..356		17/30 (57%)
		Nuclear export signal	339..350		4/10 (40%)
		Disordered. /evidence=ECO:0000269|PubMed:31953488, ECO:0000269|PubMed:36108750	351..393		12/45 (27%)
		Interaction with USP7	359..363		0/3 (0%)
		Basic (repression of DNA-binding)	368..387		6/21 (29%)
		[KR]-[STA]-K motif	370..372		0/1 (0%)
		Interaction with MORN3. /evidence=ECO:0000269|PubMed:29681526	374..393		9/22 (41%)
tp53	NP_001258749.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	53..81		13/49 (27%)
		P53	78..258	CDD:176262	131/179 (73%)
		Interaction with DNA. /evidence=ECO:0000250	242..249		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..302		16/50 (32%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	275..297		8/21 (38%)
		P53_tetramer	294..335	CDD:462238	19/40 (48%)
		Oligomerization	302..333		17/30 (57%)
		Nuclear export signal. /evidence=ECO:0000250	316..327		4/10 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..374		11/43 (26%)
		Basic (repression of DNA-binding)	346..367		6/20 (30%)