Protein Alignment TP53 and p53

DIOPT Version :10

• Sequence 1: NP_000537.3
• Gene: TP53 / 7157
• HGNCID: 11998
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_996267.1
• Gene: p53 / 2768677
• FlyBaseID: FBgn0039044
• Length: 495
• Species: Drosophila melanogaster
• Alignment Length: 282
• Identity: 65/282 - (23%)
• Similarity: 116/282 - (41%)
• Gaps: 44/282 - (15%)

Human   126 YSPALNKMFCQLAKTCPVQLWVDSTPP-PGTRVRAMAIYKQSQHMTEVVRRCPHHERCS--DSDG 187
            ||..|||::.::.|...|.:...|..| ....:|....:  |..::..|.||.:|....  .::.
  Fly   217 YSIPLNKLYIRMNKAFNVDVQFKSKMPIQPLNLRVFLCF--SNDVSAPVVRCQNHLSVEPLTANN 279

Human   188 LAPPQHLIRVE-------GNLRVEYLDDRNTFRHSVVVPY----EPPEVGSDCTTIHYNYMCNSS 241
            ....:.|:|.|       ||.:.:.:.:    |.|||||.    .....|....|:.:.::|.:|
  Fly   280 AKMRESLLRSENPNSVYCGNAQGKGISE----RFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNS 340

Human   242 CMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKK-----GEPHHELPP 301
            |:|   |:....:..||.:.|:::|::...|::|.||.|||..:|..|..|     .|...|..|
  Fly   341 CIG---RKETSLVFCLEKACGDIVGQHVIHVKICTCPKRDRIQDERQLNSKKRKSVPEAAEEDEP 402

Human   302 GSTKRALPNNT-------------SSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDA 353
            ...:|.:...|             |::.....:..||:| .|.|....:..:.:.:...::...|
  Fly   403 SKVRRCIAIKTEDTESNDSRDCDDSAAEWNVSRTPDGDY-RLAITCPNKEWLLQSIEGMIKEAAA 466

Human   354 QAGKEPG--GSRAHSSHLKSKK 373
            :..:.|.  ..|.|::.|.|.|
  Fly   467 EVLRNPNQENLRRHANKLLSLK 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TP53	NP_000537.3	Interaction with CCAR2. /evidence=ECO:0000269|PubMed:25732823	1..320		53/225 (24%)
		Interaction with HRMT1L2. /evidence=ECO:0000269|PubMed:15186775	1..83
		Transcription activation (acidic)	1..44
		P53_TAD	6..30	CDD:462520
		TADI	17..25
		TAD2	35..59	CDD:375947
		TADII	48..56
		Disordered. /evidence=ECO:0000269|PubMed:31953488	50..96
		Interaction with WWOX	66..110
		Interaction with HIPK1. /evidence=ECO:0000250	100..370		62/277 (22%)
		Required for interaction with ZNF385A. /evidence=ECO:0000269|PubMed:17719541	100..300		49/192 (26%)
		P53	109..288	CDD:176262	45/175 (26%)
		Required for interaction with FBXO42. /evidence=ECO:0000269|PubMed:19509332	113..236		28/123 (23%)
		Interaction with AXIN1. /evidence=ECO:0000250	116..292		46/179 (26%)
		Interaction with the 53BP2 SH3 domain	241..248		3/6 (50%)
		Interaction with E4F1. /evidence=ECO:0000269|PubMed:10644996	256..294		14/42 (33%)
		Interaction with DNA	273..280		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..325		10/60 (17%)
		Interaction with CARM1. /evidence=ECO:0000269|PubMed:15186775	300..393		16/89 (18%)
		Bipartite nuclear localization signal	305..321		3/28 (11%)
		Interaction with HIPK2	319..360		6/40 (15%)
		P53_tetramer	319..358	CDD:462238	6/38 (16%)
		Oligomerization	325..356		5/30 (17%)
		Nuclear export signal	339..350		0/10 (0%)
		Disordered. /evidence=ECO:0000269|PubMed:31953488, ECO:0000269|PubMed:36108750	351..393		7/25 (28%)
		Interaction with USP7	359..363		1/5 (20%)
		Basic (repression of DNA-binding)	368..387		3/6 (50%)
		[KR]-[STA]-K motif	370..372		0/1 (0%)
		Interaction with MORN3. /evidence=ECO:0000269|PubMed:29681526	374..393		65/282 (23%)
p53	NP_996267.1	P53	193..385	CDD:459972	45/176 (26%)
		P53_C	429..495	CDD:314489	12/61 (20%)