DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TP53 and Tp53

DIOPT Version :9

Sequence 1:	NP_000537.3	Gene:	TP53 / 7157	HGNCID:	11998	Length:	393	Species:	Homo sapiens
Sequence 2:	NP_112251.2	Gene:	Tp53 / 24842	RGDID:	3889	Length:	391	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	308/400 - (77%)
Similarity:	331/400 - (82%)	Gaps:	16/400 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEEPQSDPSVEPPLSQETFSDLWKLLPENNVL------SPLPSQAMDDLMLSPDDIEQWFTEDPG 59
            ||:.|||.|:|.||||||||.||||||.:::|      ||   .:|:||.| |.|:.:..   .|
  Rat     1 MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSP---NSMEDLFL-PQDVAELL---EG 58

Human    60 PDEAPRMPEAAPPV-APAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVT 123
            |:||  :..:||.. .|...||.|.|||.|..|||||||||||||||:|||.||||.|||||||.
  Rat    59 PEEA--LQVSAPAAQEPGTEAPAPVAPASATPWPLSSSVPSQKTYQGNYGFHLGFLQSGTAKSVM 121

Human   124 CTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGL 188
            ||||.:|||:||||||||||||||.||||||||||||||||:|||||||||||||||||||.|||
  Rat   122 CTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGL 186

Human   189 APPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILT 253
            ||||||||||||...||||||.||||||||||||||||||.|||||.||||||||||||||||||
  Rat   187 APPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILT 251

Human   254 IITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQP 318
            ||||||||||||||:||||||||||||||||||||.|||.|...||||||.|||||.:||||||.
  Rat   252 IITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEEHCPELPPGSAKRALPTSTSSSPQQ 316

Human   319 KKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKL 383
            ||||||||||||:||||||||||||||||||||||:|.:|.|.||||||:.|:|||||||||||.
  Rat   317 KKKPLDGEYFTLKIRGRERFEMFRELNEALELKDARAAEESGDSRAHSSYPKTKKGQSTSRHKKP 381

Human   384 MFKTEGPDSD 393
            |.|..|||||
  Rat   382 MIKKVGPDSD 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TP53	NP_000537.3	Interaction with CCAR2. /evidence=ECO:0000269\|PubMed:25732823	1..320		246/325 (76%)
		Interaction with HRMT1L2. /evidence=ECO:0000269\|PubMed:15186775	1..83		39/88 (44%)
		Transcription activation (acidic)	1..44		26/48 (54%)
		P53_TAD	6..30	CDD:369955	18/23 (78%)
		TADI	17..25		6/7 (86%)
		TAD2	35..59	CDD:375947	6/23 (26%)
		TADII	48..56		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..96		18/46 (39%)
		Interaction with WWOX	66..110		27/44 (61%)
		Interaction with HIPK1. /evidence=ECO:0000250	100..370		236/269 (88%)
		Required for interaction with ZNF385A. /evidence=ECO:0000269\|PubMed:17719541	100..300		177/199 (89%)
		P53	109..288	CDD:176262	162/178 (91%)
		Required for interaction with FBXO42. /evidence=ECO:0000269\|PubMed:19509332	113..236		109/122 (89%)
		Interaction with AXIN1. /evidence=ECO:0000250	116..292		160/175 (91%)
		Interaction with the 53BP2 SH3 domain	241..248		6/6 (100%)
		Interaction with E4F1. /evidence=ECO:0000269\|PubMed:10644996	256..294		35/37 (95%)
		Interaction with DNA	273..280		6/6 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..325		33/42 (79%)
		Interaction with CARM1. /evidence=ECO:0000269\|PubMed:15186775	300..393		75/92 (82%)
		Bipartite nuclear localization signal	305..321		12/15 (80%)
		Interaction with HIPK2	319..360		36/40 (90%)
		P53_tetramer	319..355	CDD:369476	34/35 (97%)
		Oligomerization	325..356		28/30 (93%)
		Nuclear export signal	339..350		10/10 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..393		29/41 (71%)
		Interaction with USP7	359..363		1/3 (33%)
		Basic (repression of DNA-binding)	368..387		13/18 (72%)
		[KR]-[STA]-K motif	370..372		1/1 (100%)
Tp53	NP_112251.2	Interaction with CCAR2. /evidence=ECO:0000250\|UniProtKB:P04637	1..318		246/325 (76%)
		Transcription activation (acidic)	1..47		26/48 (54%)
		P53_TAD	5..27	CDD:285732	17/21 (81%)
		Interaction with WWOX. /evidence=ECO:0000250	64..108		27/43 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..90		10/24 (42%)
		P53	93..287	CDD:279242	176/193 (91%)
		Interaction with HIPK1. /evidence=ECO:0000250	98..368		236/269 (88%)
		Required for interaction with ZNF385A. /evidence=ECO:0000250	98..298		177/199 (89%)
		Required for interaction with FBXO42. /evidence=ECO:0000250	111..234		109/122 (89%)
		Interaction with AXIN1. /evidence=ECO:0000250	114..290		160/175 (91%)
		Interaction with E4F1. /evidence=ECO:0000250	254..292		35/37 (95%)
		Interaction with DNA. /evidence=ECO:0000250	271..278		6/6 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..324		33/42 (79%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	303..319		12/15 (80%)
		Interaction with HIPK2. /evidence=ECO:0000250	317..358		36/40 (90%)
		P53_tetramer	317..356	CDD:285011	35/38 (92%)
		Oligomerization	323..354		28/30 (93%)
		Nuclear export signal. /evidence=ECO:0000250	337..348		10/10 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..391		28/40 (70%)
		Interaction with USP7. /evidence=ECO:0000250	357..361		1/3 (33%)
		Basic (repression of DNA-binding)	366..385		13/18 (72%)
		[KR]-[STA]-K motif	368..370		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	365	1.000	Domainoid score	I12112
eggNOG	1	0.900	-	-		E1_28PAR
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H460
Inparanoid	1	1.050	602	1.000	Inparanoid score	I10150
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43211
OrthoDB	1	1.010	-	-		D120188at9347
OrthoFinder	1	1.000	-	-		FOG0002925
OrthoInspector	1	1.000	-	-		oto136558
orthoMCL	1	0.900	-	-		OOG6_111128
Panther	1	1.100	-	-	LDO	PTHR11447
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6184
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.340