Protein Alignment TP53 and Trp53

DIOPT Version :10

• Sequence 1: NP_000537.3
• Gene: TP53 / 7157
• HGNCID: 11998
• Length: 393
• Species: Homo sapiens
• Sequence 2: NP_035770.2
• Gene: Trp53 / 22059
• MGIID: 98834
• Length: 390
• Species: Mus musculus
• Alignment Length: 393
• Identity: 304/393 - (77%)
• Similarity: 326/393 - (82%)
• Gaps: 6/393 - (1%)

Human     1 MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPR 65
            |||.|||.|:|.||||||||.||||||..::| |.| ..||||:| |.|:|::|   .||.||.|
Mouse     4 MEESQSDISLELPLSQETFSGLWKLLPPEDIL-PSP-HCMDDLLL-PQDVEEFF---EGPSEALR 62

Human    66 MPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPAL 130
            :..|.....|....|.|.|||||..|||||.|||||||||:|||.||||.|||||||.|||||.|
Mouse    63 VSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPL 127

Human   131 NKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI 195
            ||:||||||||||||||.:|||.|:|||||||||:|||||||||||||||||||.||||||||||
Mouse   128 NKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLI 192

Human   196 RVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDS 260
            ||||||..|||:||.||||||||||||||.||:.|||||.|||||||||||||||||||||||||
Mouse   193 RVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDS 257

Human   261 SGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDG 325
            |||||||:||||||||||||||||||||.|||.....||||||.|||||..||:||..|||||||
Mouse   258 SGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDG 322

Human   326 EYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGP 390
            |||||:||||:|||||||||||||||||.|.:|.|.||||||:||:|||||||||||.|.|..||
Mouse   323 EYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGP 387

Human   391 DSD 393
            |||
Mouse   388 DSD 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TP53	NP_000537.3	Interaction with CCAR2. /evidence=ECO:0000269|PubMed:25732823	1..320		242/318 (76%)
		Interaction with HRMT1L2. /evidence=ECO:0000269|PubMed:15186775	1..83		42/81 (52%)
		Transcription activation (acidic)	1..44		28/42 (67%)
		P53_TAD	6..30	CDD:462520	18/23 (78%)
		TADI	17..25		6/7 (86%)
		TAD2	35..59	CDD:375947	10/23 (43%)
		TADII	48..56		3/7 (43%)
		Disordered. /evidence=ECO:0000269|PubMed:31953488	50..96		20/45 (44%)
		Interaction with WWOX	66..110		25/43 (58%)
		Interaction with HIPK1. /evidence=ECO:0000250	100..370		228/269 (85%)
		Required for interaction with ZNF385A. /evidence=ECO:0000269|PubMed:17719541	100..300		172/199 (86%)
		P53	109..288	CDD:176262	158/178 (89%)
		Required for interaction with FBXO42. /evidence=ECO:0000269|PubMed:19509332	113..236		105/122 (86%)
		Interaction with AXIN1. /evidence=ECO:0000250	116..292		156/175 (89%)
		Interaction with the 53BP2 SH3 domain	241..248		6/6 (100%)
		Interaction with E4F1. /evidence=ECO:0000269|PubMed:10644996	256..294		35/37 (95%)
		Interaction with DNA	273..280		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..325		30/42 (71%)
		Interaction with CARM1. /evidence=ECO:0000269|PubMed:15186775	300..393		73/92 (79%)
		Bipartite nuclear localization signal	305..321		10/15 (67%)
		Interaction with HIPK2	319..360		35/40 (88%)
		P53_tetramer	319..358	CDD:462238	34/38 (89%)
		Oligomerization	325..356		27/30 (90%)
		Nuclear export signal	339..350		10/10 (100%)
		Disordered. /evidence=ECO:0000269|PubMed:31953488, ECO:0000269|PubMed:36108750	351..393		30/41 (73%)
		Interaction with USP7	359..363		1/3 (33%)
		Basic (repression of DNA-binding)	368..387		14/18 (78%)
		[KR]-[STA]-K motif	370..372		1/1 (100%)
		Interaction with MORN3. /evidence=ECO:0000269|PubMed:29681526	374..393		14/18 (78%)
Trp53	NP_035770.2	Interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:P04637	4..317		242/318 (76%)
		Transcription activation (acidic)	4..45		28/42 (67%)
		P53_TAD	9..31	CDD:462520	17/21 (81%)
		Interaction with WWOX. /evidence=ECO:0000250	63..107		25/43 (58%)
		Interaction with HIPK1. /evidence=ECO:0000269|PubMed:12702766	97..367		228/269 (85%)
		Required for interaction with ZNF385A. /evidence=ECO:0000250	97..297		172/199 (86%)
		P53	106..286	CDD:176262	159/179 (89%)
		Required for interaction with FBXO42. /evidence=ECO:0000250	110..233		105/122 (86%)
		Interaction with AXIN1. /evidence=ECO:0000269|PubMed:15526030	113..289		156/175 (89%)
		Interaction with E4F1. /evidence=ECO:0000250	256..294		32/37 (86%)
		Interaction with DNA	270..277		6/6 (100%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	302..318		10/15 (67%)
		Interaction with HIPK2. /evidence=ECO:0000250	316..357		35/40 (88%)
		P53_tetramer	316..350	CDD:462238	31/33 (94%)
		Oligomerization	322..353		27/30 (90%)
		Nuclear export signal. /evidence=ECO:0000250	336..347		10/10 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..390		30/41 (73%)
		Interaction with USP7. /evidence=ECO:0000250	356..360		1/3 (33%)
		Basic (repression of DNA-binding)	365..384		14/18 (78%)
		[KR]-[STA]-K motif	367..369		1/1 (100%)