DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TOP1 and Top1

DIOPT Version :9

Sequence 1:NP_003277.1 Gene:TOP1 / 7150 HGNCID:11986 Length:765 Species:Homo sapiens
Sequence 2:NP_001014742.1 Gene:Top1 / 32458 FlyBaseID:FBgn0004924 Length:974 Species:Drosophila melanogaster


Alignment Length:963 Identity:474/963 - (49%)
Similarity:576/963 - (59%) Gaps:228/963 - (23%)


- Green bases have known domain annotations that are detailed below.


Human     5 HLHNDSQIEADFRLNDSHKH----KDKHKDREHRH---------KEHK---KEKDREKSKHSNSE 53
            |.|:.|.       :.|.||    ||||:|||..|         ||||   ::|||.||..|:|:
  Fly    38 HHHSSSS-------SSSSKHKSSSKDKHRDREREHKSSNSSSSSKEHKSSSRDKDRHKSSSSSSK 95

Human    54 HKDSEKKHKEKEKTKHKDGSSEKHKDK--------------HK--DRDKEKRKEEKVRASGDAKI 102
            |:|.:|: ::.....|:.|||..||||              ||  .:|||:|.::|.|.|..:..
  Fly    96 HRDKDKE-RDGSSNSHRSGSSSSHKDKDGSSSSKHKSSSGHHKRSSKDKERRDKDKDRGSSSSSR 159

Human   103 KK------EKENG---------------------FSSPPQIKDEPEDDGYFVPP----------- 129
            .|      :||..                     .||....||:|..||.||.|           
  Fly   160 HKSSSSSRDKERSSSSHKSSSSSSSSKSKHSSSRHSSSSSSKDQPSYDGVFVKPEPVSQQLMHSG 224

Human   130 -------------------------------------KEDIKPLKRPRD---------------- 141
                                                 :|.|..:|:..:                
  Fly   225 SVDAFQMQQLGSYEAAAAGTNFNGNGNVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMS 289

Human   142 -----------------------------EDDAD------------------------------- 146
                                         :||||                               
  Fly   290 QFRADEPPFVVKHEQSYAEEDSTMNYNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDND 354

Human   147 ------------YKPKKIKTEDTKKEKKRKLEEEED--GKLKKPKNKDKDKKVPEP-----DNKK 192
                        .|.:|||.|..:|.|||..||..|  |.: |||.| |.||.|||     ..:|
  Fly   355 DDDDIPLLARKKVKKEKIKKESKEKSKKRVKEEPSDDYGNV-KPKKK-KMKKEPEPAVSPGKRQK 417

Human   193 KKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVA 257
            .|.|.|||:.|:|||||:..:|:||..||||||||||.||.:|.||:||||||.::||.:.||.|
  Fly   418 AKAKVEEEEVWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELSEETEEAA 482

Human   258 TFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKE 322
            ||:||||:|:|.|||:|..|||||:||.||..|:.||.:..||:|.:|..||:|::|.||..|||
  Fly   483 TFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREIIKDFRKCNFQEMFNYFQAESEKRKAASKE 547

Human   323 EKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCS 387
            |||..|.|||.|:||:|||::|.|||:|.||::||||||||||.||||||:||||...|:.|||.
  Fly   548 EKLIKKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCG 612

Human   388 KDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKK 452
            ||:||||||||.:||||||||.||||.||.||:||.:|||||||||::|||||..||||||||.|
  Fly   613 KDSKVPSPPPGSRWKEVRHDNTVTWLASWIENVQGQVKYIMLNPSSKLKGEKDHIKYETARRLDK 677

Human   453 CVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPE 517
            .:||||..||::||||||:||||||||||||||||||||||:| :.|||||||||||||:.||.|
  Fly   678 VIDKIRATYRDEWKSKEMRVRQRAVALYFIDKLALRAGNEKDE-DQADTVGCCSLRVEHVQLHKE 741

Human   518 LDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLME 582
            |:|:|.||.|||.|||||||||:|.|||||||||:||||:|:..|||||||||.:||:||::|||
  Fly   742 LNGKENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEHKKEGDDLFDRLNTQVLNEHLKELME 806

Human   583 GLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNL 647
            |||||||||||||.|||.||..||.|...:|.|:|:||||||||||||||||:.||:.||||.||
  Fly   807 GLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSVPKSHEKSMENL 871

Human   648 QTKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENK 712
            :.||.||:|.:.....:..|        :|       |.|.|.::||.:||.|||:|.|||:|||
  Fly   872 KEKIKAKREAIEKCESEYHS--------RD-------EKKGKQLERLRDQLKKLELQETDRDENK 921

Human   713 QIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 765
            .|||||||||||||||:||||||..||||||:|||||.||.||:.||||:|.|
  Fly   922 TIALGTSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMADENYRF 974

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TOP1NP_003277.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..199 91/395 (23%)
Topoisom_I_N 215..429 CDD:367250 140/213 (66%)
TOPEUc 360..737 CDD:214661 263/376 (70%)