DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C1R and CG11313

DIOPT Version :9

Sequence 1:	NP_001341275.1	Gene:	C1R / 715	HGNCID:	1246	Length:	719	Species:	Homo sapiens
Sequence 2:	NP_651821.3	Gene:	CG11313 / 43646	FlyBaseID:	FBgn0039798	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	281	Identity:	74/281 - (26%)
Similarity:	120/281 - (42%)	Gaps:	47/281 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   464 VCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGG--------GALLGDRWILTAAHTLYP 520
            :||..:    ...:|..|.:..:..|.|.|........|        |:|:.:|:::||||.:..
  Fly   106 ICGGDI----AYNQITKGNETVLTEFAWMVLLEYRPHDGQQLRTYCAGSLINNRYVVTAAHCVSA 166

Human   521 KEHEAQSNAS--LDVFLGHTNVEELMKLGN-----HPIRRVSVHPDYRQDESYN---FEGDIALL 575
            .....:.:.|  :.|.||..|...::...|     .|: :::|. :.|..||:.   |..||||:
  Fly   167 ATRARKGDVSFRVSVRLGEHNTSAVVDCLNGRCLPEPV-QIAVE-EIRIHESFGTRLFWNDIALI 229

Human   576 ELENSVTLGPNLLPICLPDNDTFYDLGLMGY-------VSGFG--VMEEKIAHDLRFVRLPVANP 631
            .|...|...|::.|:|||..     :||..:       |:|:|  :..|.....:: :|:....|
  Fly   230 RLAREVAYSPSIRPVCLPST-----VGLQNWQSGQAFTVAGWGRTLTSESSPVKMK-LRVTYVEP 288

Human   632 QACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR 696
            ..|.   |....:.|...:..||...| :.|:|.|||||.........  ||..||||:|:.|..
  Fly   289 GLCR---RKYASIVVLGDSHLCAEGRS-RGDSCDGDSGGPLMAFHEGV--WVLGGIVSFGLNCGS 347

Human   697 GY--GFYTKVLNYVDWIKKEM 715
            .:  ..||.||:|..||.:.:
  Fly   348 RFWPAVYTNVLSYETWITQNI 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C1R	NP_001341275.1	CUB	41..152	CDD:214483
		FXa_inhibition	175..203	CDD:317114
		CUB	207..316	CDD:278839
		Sushi	323..385	CDD:306569
		Sushi	390..461	CDD:306569
		Tryp_SPc	477..711	CDD:214473	70/262 (27%)
CG11313	NP_651821.3	CLIP	24..78	CDD:288855
		Tryp_SPc	116..367	CDD:238113	72/264 (27%)
		Tryp_SPc	116..364	CDD:214473	70/261 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910