DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNXB and bt

DIOPT Version :9

Sequence 1:	NP_001352205.1	Gene:	TNXB / 7148	HGNCID:	11976	Length:	4244	Species:	Homo sapiens
Sequence 2:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster

Alignment Length:	4604	Identity:	866/4604 - (18%)
Similarity:	1417/4604 - (30%)	Gaps:	1710/4604 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   767 TEW-------------TPAPGPVDAYEIQFIPTTEGASPPFTA--RVPSSASAYDQRGLAPGQEY 816
            |:|             |....|:.||.:::   .|..|..:.:  .|...|......||..||:|
  Fly  2212 TDWDKDHADLKWEAPETDGGDPITAYIVEY---KEKFSNDWVSGKEVDGDARTATVDGLKEGQQY 2273

Human   817 QVTVRALRGTSWGLPASKT---------ITTMIDGPQDLRVVAVTPTTLELGWLRPQAEVDRFVV 872
            :..|||:.....|.|:.||         :...|.| :.|:.|.|           .:.:..||.:
  Fly  2274 EFRVRAVNRAGPGEPSDKTKSIIAKCRFVKPFIVG-EGLKNVTV-----------KKGQTIRFDI 2326

Human   873 SY----------------VSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGRAVSYPAS 921
            .|                :...|||:.|:                       ..||..:::...|
  Fly  2327 KYDGEPEPAATWVKGTDNLKFDNQRICLD-----------------------QLERNSSITIKKS 2368

Human   922 VRANTGSSPLGLLGTT------------DEP-PPSGPSTTQGAQAPLLQ---QRPQELGELRVLG 970
            ||.:||...|.|..::            |.| ||.||...:..:|..::   :||.:.|...:.|
  Fly  2369 VRKDTGKYKLVLSNSSGTIESEAQVVVLDRPLPPGGPFEPEEIRASHIKMKWKRPDDDGGCEISG 2433

Human   971 ------RDETGRLRVVWTAQPDTFAYFQLRMRVPEGPGAHEEVLPGDVR---QALVPPPPPGTPY 1026
                  .:||||    |               :|.|     ||.|.:..   :.|.    |...|
  Fly  2434 YALERMDEETGR----W---------------IPAG-----EVGPNETSFDFKGLT----PNKKY 2470

Human  1027 ELSLHGVPPGGKPSDPI-IYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLLRWTVPEGE-- 1088
            :..:..:...|: |:|: .:..|:.::...|   ..||  .:..:.|..:.|:||:|..|..:
  Fly  2471 KFRVKAINKEGE-SEPLETFDAIVARNPYDP---PSPP--SQPVIDDYDNKSVLLKWKRPPSDGG 2529

Human  1089 --FDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDP-------GRKYKFVLYGF----VGKKRHG 1140
              ...::::.||:         ..|..|.|..:.||       |.|.|.| |.|    |.|.  |
  Fly  2530 RPITHYIVEIKDK---------FAPSWSEVAKTDDPNPECNVEGLKEKMV-YQFRVRAVNKA--G 2582

Human  1141 PLVAEAKILPQSDPSPGTPPHL---GNL---------------------WVTD----PTPDSLHL 1177
            |          |:||..|..||   .||                     |..|    |.|: ||.
  Fly  2583 P----------SEPSQPTDNHLCKHKNLKPQIDRSTFKRVTIKSGRTHKWSVDVLGEPIPE-LHW 2636

Human  1178 SWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANK-KRYGPLTA 1241
            ||                ||.    :|:...:|   :...:.|:...|::..:..| ..:..|.|
  Fly  2637 SW----------------RDD----IPLTNGDR---IKIENVDYHTDFSITNVLRKDSGFYTLKA 2678

Human  1242 DGTTAPERKE-------EPPRPEFLEQPLLGELTVTGVTPDSLRLSWTVAQG----PFDSFMVQY 1295
            :.....:|:.       :|..|:       |.|.|:.||....:|.|...:.    |...::|:.
  Fly  2679 ENRNGIDRETVELVVLGKPSSPK-------GPLAVSDVTASGCKLQWKKPEDDGGVPIKEYVVEK 2736

Human  1296 KD-AQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAPQEDVDETPSP 1359
            .| |.|  :.|.|.....|...|..|        :.||    .:|.|.:...:|..|:.:..|..
  Fly  2737 MDTATG--KWVRVGRSPGEKEPPSFD--------VTGL----SLGSEYMFRVSAVNEEGESEPLT 2787

Human  1360 TELGTEAPESPEEP-LLGELTVTGSSPDSLSLFWTVPQGS----FDSFTVQYKDRDGR--PRAVR 1417
            |.:|..|.:..:|| ..|...||.....|:||.|..|...    ...:.::.|:::..  .:|:.
  Fly  2788 TLVGVVAKDPFDEPNKPGTPEVTDYDNQSISLKWAAPNNDGGAPIQKYIIEKKNKNKTEWEKALE 2852

Human  1418 VGGKESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQQEETPPATE-SPLEPRLGELT 1481
            :.|.:.|.||.||:...:|:.         ||..|:..|::.|.....|...: ..|:||:..
  Fly  2853 IPGDQLEATVAGLQEYGEYQF---------RVIAVNKAGLSPPSDASVPQIVKYKKLKPRIDR-- 2906

Human  1482 VTDVTPNSVGLSWTV-----PEGQFDSFIVQYK-DKDGQPQVVPVAADQREVTVYN-----LEPE 1535
             :::.|..:.....:     ..|:....|..|: ||:.:|:.:|.:::.:.:. ||     :|..
  Fly  2907 -SNLKPLLIRAGKPIRYDVNVRGEPAPVITWYQNDKELKPEELPSSSEIKNIP-YNTKISIIETV 2969

Human  1536 RK----YKMNMYGLHDGQRMGPLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLS 1596
            ||    ||:.....| ||....:.|.|:.             ||.:|| |.|.|.|:|.||..|.
  Fly  2970 RKHTGIYKIIAVNEH-GQDEATVEVNILA-------------PPSKPR-GPLDVKDVTKDSCKLK 3019

Human  1597 WTVPEGE----FDSFVVQYKDRDGQPQVVPV---AADQREVTIPDLEPSRKYKFLLFGIQDGKRR 1654
            |..||.:    ..::.|:..|:. |.:.||:   :|:..|..:..|:...:|:|.:..|.:....
  Fly  3020 WKKPEDDGGKPISAYQVEKFDKK-QGRWVPLGRTSANDTEFDVKGLQEGHEYQFRVKAINEEGES 3083

Human  1655 SPVSVEAKTVARG--DAS--PGAPPRLGELWVTDPTPDSLRLSWTVPEGQ----FDSFVVQFKDK 1711
            .|:..:...:|:.  ||:  ||.|.      :.|.....::|.|..|...    ...::::.|||
  Fly  3084 DPLDSDDSIIAKNPYDAASKPGTPN------IVDYNEHMVKLKWEAPRSDGGAPISGYIIEKKDK 3142

Human  1712 DGP---QVVPVEGHERSVTVTPLDAGRKYRFLLYGL---------------LGKKRH-------- 1750
            ..|   :::.........||..|..|..|:|.:..:               |.|.|:
  Fly  3143 FSPIWDEILSTNTSVPEATVEGLVEGNIYQFRVRAVNKAGFSDPSDATEPHLAKPRNLKPYINRD 3207

Human  1751 ----------GPLTAD---------------------GTTEARSAMDDTGTK------------- 1771
                      .|:..|                     .|.:.|....|..||
  Fly  3208 KMKPIKVRAGQPVKFDVDVKGEPAPSLTWFLKETELTSTGQVRLENIDYNTKLTLLDTDRKQSGQ 3272

Human  1772 ----------------------RPPKPRLGEELQVTTVTQNSVGLSWTVPEGQ----FDSFVVQY 1810
                                  :|.||.  ..::|:.:.:....|.|..|:..    ...:|::.
  Fly  3273 YKLRAENINGVDEAVVEVIILDKPSKPE--GPIEVSDIHKEGCKLKWRKPKDDGGIPITGYVIEK 3335

Human  1811 KDRDGQPQVVP---VEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETET 1872
            .| ....:.||   |:....::.:.||||.|||:..:..::......|:          |||:..
  Fly  3336 MD-TATGKWVPAGSVDPEKYDIEIKGLDPNHRYQFRVKAVNEEGESEPL----------ETESAI 3389

Human  1873 TAPTP---PAPEPHLGELTVEEATSHTLHLSW--------------------------------- 1901
            ||..|   .|| |.|.||  |:...|.:.|.|
  Fly  3390 TAKNPFDVSAP-PGLPEL--EDWDEHHVKLKWEPPIRDGGSPITNYIIEVMDKDSGEFVKAVETD 3451

Human  1902 ---------MVTEGEFDSFEIQYTDRDGQLQ---------------------------MVRIG-- 1928
                     .:.||:...|.::..::.|...                           :|:.|
  Fly  3452 SPVCKGVVKKLEEGQQYKFRVRAVNKAGPSDPSEQTNWHVAKPRFLKPHIDRVNLKPVIVKTGLS 3516

Human  1929 -------------------------GDRNDITLSGLESDHRYLVTLYGFS-DGKHVGPVHVEALT 1967
                                     .|.:.:.:..::.:.::.|.....| .||::    ::|..
  Fly  3517 ISLDINIRGEPAPKVEWFFNNSSVTSDEHSVKIDNVDYNTKFFVMRAQRSQSGKYI----IKATN 3577

Human  1968 VPEEEKPSEPPTATPEPPIKPRLGELTVTDATPDSLSLSWTVPE----GQFDHFLVQY---RNGD 2025
            ...|::.....|...:|. ||: |.|.|.|.|..|..|.|..|:    ...|::.::.   ..|.
  Fly  3578 EVGEDEAELEVTVLGKPG-KPK-GPLQVNDITKHSCKLKWEKPDDDGGSPIDYYEIEKLDPHTGQ 3640

Human  2026 GQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQ----RMGPVSVVGVTAAEEETPSPTEPS 2086
            ..|..            ...||:.|    :.|.|.|:    |:..|:..|     |.....||..
  Fly  3641 WLPCG------------KSTEPEAK----VIGLHEGKAYKFRVRAVNKEG-----ESEDLETEKP 3684

Human  2087 MEAPEPAEEP-LLGELTVTGSSPDSLSLSWTVPQ----GRFDSFTVQYKDRDGRPQV--VRVGGE 2144
            :.|..|.:|| ..|:...|....|.:.|:|..|:    .....:.:|.:|:.||..|  ..|.|:
  Fly  3685 IIAKNPYDEPDRPGKPEPTNWDKDFVDLAWDPPKNDGGAPIQKYVIQMRDKSGRAWVDSATVPGD 3749

Human  2145 ESEVTVGGLEPGRKYKMHLYGLHEGRRVGP-----------------------------VSAVG- 2179
            :...||.|:|.|.:|:..:..::   :.||                             :...|
  Fly  3750 KCNGTVTGVEEGHEYEFRIVAVN---KAGPSDPSDVSKSVIAKPRFLKPHIDRKNLQKKIMRSGQ 3811

Human  2180 --------------------------------------------------------VTAPEEESP 2188
                                                                    |||..:...
  Fly  3812 MLHIDALIKAEPPAKVTWTYNKTEIKTSDHIKIENEDYKTTFIMPKVKRADRGIYIVTAKNDSGS 3876

Human  2189 DAPLAKLRL--------GQMTVRDITSDSLSLSWTVPEGQ----FDHFLVQ-------------- 2227
            |....:|.:        |.:.|.::|:::|.|.|..||..    .:.:||:
  Fly  3877 DTVEVELEVLCKPSKPKGPLAVSNVTAETLHLKWEKPEDDGGDPIEQYLVERMDTETGRWVPVLT 3941

Human  2228 --------------------------------------------FKNGD--GQPKAV-------- 2238
                                                        |...|  |:|:.|
  Fly  3942 TKTPEADVTGLTEGKEYLFRVKAVNSEGESEPLVTDIPTKAKNPFDAADTPGKPQIVDWSGNHCD 4006

Human  2239 ---RVPGHEDGVTISG----------------LE---PDHKYKM------NLYGFHGGQRVGPVS 2275
               |.|..:.|.:|:|                ||   ||.|.::      |.|.|    |:..|:
  Fly  4007 LKWRAPEDDGGASITGYIVERKDPNTGKWQKALETSTPDCKARVNDLIAGNKYQF----RIMAVN 4067

Human  2276 AVGLTAPGK-DEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKN 2339
            ..|.:.|.: .::|.......|       |:::...:.|.         |:..||...|.::.
  Fly  4068 KAGKSKPSEPSDQMTAKDRFAP-------PKIDRTNIKDI---------TIKAGQHIRFDIKV-- 4114

Human  2340 GDGQPKATRVPGHEDRVTISGLE-PDNKYKMNLYG------------FHGGQRVGPVSAIGVTAA 2391
             .|:|.||:|..|..    :.|| .|:.|.:::..            ||.|:         .|..
  Fly  4115 -SGEPPATKVWLHNK----ARLENDDSNYNIDMESYRTKLTVPISKRFHSGK---------YTLK 4165

Human  2392 EEETPSPTEPSMEA-----PEPPEEPLLGELTVTGSSPDSLSLSWTVPQG----RFDSFTVQYKD 2447
            .|......|.|.|.     |.|||    |.|.||....:...|.|..|..    ..|.:.::..|
  Fly  4166 AENESGRDEASFEVIVLDKPGPPE----GPLRVTDVHKEGCKLKWNAPLDDGGLPIDHYIIEKMD 4226

Human  2448 RDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVG----VTAPQEDVDETPS 2508
            .:....:.....:||...:..|||..:||.         ||..|:|.|    :|..|..:.:.|.
  Fly  4227 VESGRWLPSGRFKESFAELNNLEPSHEYKF---------RVLAVNTEGESEPLTGEQSVIAKNPF 4282

Human  2509 PTEPGTEAPGPPEEPLLGELTVTGSSPDSLSLSWTVP----QGRFDSFTVQYKDR------DGRP 2563
             .|||  .||.||        ......|.:.|.|..|    ......:.|:.:::      .|..
  Fly  4283 -DEPG--KPGTPE--------AVDWDKDHVDLVWRPPINDGGSPITGYVVEKREKGTDKWIKGTE 4336

Human  2564 QAVRVGGQESKVTVRGLEPGRKYKMHLYGLH----------------EGRRLGP----------- 2601
            ..:...|:|.|.||..|....:|:..:..::                :.|:|.|
  Fly  4337 ITIPCLGEECKATVPTLNENCEYEFRVKAINAAGPGEPSDASKPIITKPRKLAPKIDRKNIRTYN 4401

Human  2602 ------------VS---AVGVTEDE----AETT-----QAVPTMT------PE------------ 2624
                        :|   |..||.::    .:||     :.:|..|      ||
  Fly  4402 FKSGEPIFLDINISGEPAPDVTWNQNNKSVQTTSFSHIENLPYNTKYINNNPERKDTGLYKISAH 4466

Human  2625 ----------------PPIKPRLGELTMTDATPDSLSLSWTVPEGQ----FDHFLVQYRNGDGQP 2669
                            .|.||. |.|.:::...|...|.|..|:..    .:.:||:..:.|
  Fly  4467 NFYGQDQVEFQINIITKPGKPE-GPLEVSEVHKDGCKLKWKKPKDDGGEPVESYLVEKFDPD--- 4527

Human  2670 KAVRVP-GHEDG--VTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPSPTELSTEAP 2731
            ..:.:| |..||  ..:.||.|.|.||..:...:......|:..:|...|::....||:  ...|
  Fly  4528 TGIWLPVGRSDGPEYNVDGLVPGHDYKFRVKAVNKEGESEPLETLGSIIAKDPFSVPTK--PGVP 4590

Human  2732 EPPEEPLLGELTVTGSSPDSLSLSWTIPQGH----FDSFTVQYKDRDGR--PQVMRVRGEESEVT 2790
            ||           |..:.:.:.|:|..|...    ...:.|:.||:...  .:.:.........|
  Fly  4591 EP-----------TDWTANKVELAWPEPASDGGSPIQGYIVEVKDKYSPLWEKALETNSPTPTAT 4644

Human  2791 VGGLEPGRKYKMHLYGLHEG----------------RRVGP---------------------VST 2818
            |.||..|.:|:..:..|::|                |.:.|                     .:.
  Fly  4645 VQGLIEGNEYQFRVVALNKGGLSEPSDPSKIFTAKPRYLAPKIDRRNLRNITLSSGTALKLDANI 4709

Human  2819 VGVTAPEDE---------------AET-----------TQ-----------------------AV 2834
            .|..||:.|               .||           ||                       .|
  Fly  4710 TGEPAPKVEWKLSNYHLQSGKNVTIETPDYYTKLVIRPTQRSDSGEYLVTATNTSGKDSVLVNVV 4774

Human  2835 PTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQ----FDHFLVQYRNGDGQPKVVRVPGHED 2895
            .|..|.|||    |.|.::|...:...|.|..|...    .::|.:.....:....:......|.
  Fly  4775 ITDKPSPPN----GPLQISDVHKEGCHLKWKRPSDDGGTPIEYFQIDKLEPETGCWIPSCRSTEP 4835

Human  2896 GVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGE-LT 2959
            .|.::||.|.::||..              |..|.|..|..|...:.|..|..|.:||...| |.
  Fly  4836 QVDVTGLSPGNEYKFR--------------VSAVNAEGESQPLVGDESIVARNPFDEPGKPENLK 4886

Human  2960 VTGSSPDSLSLSWTIP----QGRFDSFTVQYKDRDGR-PQVVRVRGEESEVTVGGLEPGCKYKMH 3019
            .|....|.:.|:||.|    ......:.::.:|:.|: .:.:.|..::.:.|:..|..|..||.
  Fly  4887 ATDWDKDHVDLAWTPPLIDGGSPISCYIIEKQDKYGKWERALDVPADQCKATIPDLVEGQTYKF- 4950

Human  3020 LYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIKPRLGELTVTDATPDSLSLSWMVPE 3084
                    ||..|:|.|...|.|  .|...:.....:|||..|...:.|......|.:....|
  Fly  4951 --------RVSAVNAAGTGEPSD--STPPIIAKARNKPPIIDRSSLVEVRIKAGQSFTFDCKV-- 5003

Human  3085 GQFDHFLVQYRNGDGQPKA-----VRVPGHEDGVTISGLEPDHKYKMN--------LYGFHGGQR 3136
                       :|:..|:.     .:....:|.|.::.::.:.|.|:|        :|.......
  Fly  5004 -----------SGEPAPQTKWLLKKKEVYSKDNVKVTNVDYNTKLKVNSATRSDSGIYTVFAENA 5057

Human  3137 VGPVSA-IGVTEEETPSPTEPSTEAPEAPEEPLLGELTVTGSSPDSLSLSWTVPQ---GR-FDSF 3196
            .|..|| :.||..:.|:|       |..|       |.|...:.:|.:|.|..|.   |: .|::
  Fly  5058 NGEDSADVKVTVIDKPAP-------PNGP-------LKVDEINSESCTLHWNPPDDDGGQPIDNY 5108

Human  3197 TVQYKDRD-------GQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSTV-GITA 3253
            .|:..|..       |:..     |..:.:.||||.||.|||..:...:......|::|. .|.|
  Fly  5109 VVEKLDETTGRWIPAGETD-----GPVTALKVGGLTPGHKYKFRVRAKNRQGTSEPLTTAQAIIA 5168

Human  3254 PLPTPLPVEPRLGELAVAAVTSDSVGLSWT--VAQG--PFDSFLVQYRD--AQGQPQAVPVSGDL 3312
            ..|..:|.:|  |...:.....:.|.|.||  .|.|  |...::|:.||  :....:...:|.|:
  Fly  5169 KNPFDVPTKP--GTPTIKDFDKEFVDLEWTRPEADGGSPITGYVVEKRDKFSPDWEKCAEISDDI 5231

Human  3313 RAVAVSGLDPARKYKFLLFGLQNGKRHGP------------------------------------ 3341
            ....|..|....||:|.:..:.......|
  Fly  5232 TNAHVPDLIEGLKYEFRVRAVNKAGPGSPSDATETHVARPKNTPPKIDRNFMSDIKIKAGNVFEF 5296

Human  3342 -VPVEARTAP-------------------------------DTK--------------------- 3353
             |||.....|                               |.|
  Fly  5297 DVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRTKIRILDAKRSDTGVYTLTARNINGTDRHN 5361

Human  3354 --------PSPRLGELTVTDATPDSVGLSWTVPE----GEFDSFVVQYKDKDGRLQVVPVA-ANQ 3405
                    ||...|.|...|.:.:|:.|.|..|:    .|...:||:..|.:. ::.|||. ...
  Fly  5362 VKVTILDAPSVPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEA-MRWVPVGDCTD 5425

Human  3406 REVTVQGLEPSRKYRFLLYGLSGRKRLGPISADSTTAPLEKE----LPPHLGELTVAEETSSSLR 3466
            .|:....|..:..|.|.:..::.:.:..|:   :|:.|:..:    .|...|:....:.....:.
  Fly  5426 TEIRADNLIENHDYSFRVRAVNKQGQSQPL---TTSQPITAKDPYSHPDKPGQPQATDWGKHFVD 5487

Human  3467 LSWTVAQ----GPFDSFVVQYRDTDGQ-PRAVPVAADQRTVTVEDLEPGKKYKFLLYGLLGG--- 3523
            |.|:..:    .|..|::::.|...|| .||..|..|.....|.:|..|.:|:|.:..:..|
  Fly  5488 LEWSTPKRDGGAPISSYIIEKRPKFGQWERAAVVLGDNCKAHVPELTNGGEYEFRVIAVNRGGPS 5552

Human  3524 -------------KRLGPV--------------SALGMTAPEEDTPAP----------------- 3544
                         :.|.|.              ..||.|.|.|.:|.|
  Fly  5553 DPSDPSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPLITWLYNGKEIGSNSRG 5617

Human  3545 -------ELAPE---------------------------------APEPPEEPRLGVLTVTDTTP 3569
                   ||..|                                 .|.||:.|    |.:|..|.
  Fly  5618 ESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSFDASAHATVLDRPSPPKGP----LDITKITR 5678

Human  3570 DSMRLSWSVAQGPFDSFVVQY-------------------------------------------- 3590
            |...|:|:|......|.::.|
  Fly  5679 DGCHLTWNVPDDDGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVHRKEYLFRVKAVNAI 5743

Human  3591 --------------------EDTNGQPQALLVDGDQ------------------SKILISGLEPS 3617
                                .|..|:|  ::.|.|:                  |:.:|...|..
  Fly  5744 GESDPLEAVNTIIAKNEFDEPDAPGKP--IITDWDRDHIDLQWAVPKSDGGAPISEYIIQKKEKG 5806

Human  3618 TPYRFLLYGLHEGKRLG--PLSAEG------TTGLAPAGQTSEESRPRLSQLSVTDVTTSSLRLN 3674
            :||...:..:...|...  |...||      ...:..||| ||.|.|       :|:..:..|.
  Fly  5807 SPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQ-SEPSEP-------SDMIMAKPRY- 5862

Human  3675 WEAPPG--------------AFDSFLLRFGVPSP-STLEPHPRPLLQRE-LMVPGTRHSAVLRDL 3723
              .||.              .|.:.:...|.|:| :|...:..|||..: ..:....|.:|:..:
  Fly  5863 --LPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVVHTV 5925

Human  3724 R-----SGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESP----RDLQFSEIRETSAKVNWMPP 3779
            .     ||..:.|    ||.....|  :|:...:  ||:.|    ..:::.||...|..::|.||
  Fly  5926 NCQRSDSGIYHLL----LRNSSGID--EGSFELV--VLDRPGPPEGPMEYEEITANSVTISWKPP 5982

Human  3780 PSRADSFKVSY-----QLADGG--EPQSVQVDGQARTQKLQGLIPGARYEVTVVSVRGFEESEPL 3837
            .....|...||     .|..||  .|....|..:.....:..|:.|..||:.|::......|:||
  Fly  5983 KDNGGSEISSYVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPL 6047

Human  3838 TG-------FLTTVPDGPTQLRALNLTEGFAVLHWKPP----QNPVDTYDVQ------------- 3878
            |.       ...|||..|.:....:..:....:.||.|    .:|:..||::
  Fly  6048 TSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIKIN 6112

Human  3879 --------------------------VTAPG------------APPLQAE--------------- 3890
                                      |.|.|            |.||:.:
  Fly  6113 GQPVPTAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKV 6177

Human  3891 --------------TPGSAVDYPLHDLVL--------HTNYTATVRGLRGPNLTSPASITFTTGL 3933
                          .|...:::...||.|        .||...|:..:...|.......|.|...
  Fly  6178 RAGEPVNLNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAAN 6242

Human  3934 EAPRD------------------LEAKEVTPRTALLTWTEPP----VRPAGYLLSFHTPGGQNQE 3976
            |..:|                  |...|..|....|.|..|.    ....||::.| |..|.:..
  Fly  6243 EFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEF-TEFGVDDW 6306

Human  3977 ILLPGGI--TSHQLLGLFPSTSYNARL---------QAMWGQSLL------------PPVSTSFT 4018
            ..:||..  |:..:..|.....|..|:         :|:.|:.:|            .|..:::|
  Fly  6307 KPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAYT 6371

Human  4019 TGGLRIPF--PRDCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWL 4070
            .....:.:  |.|||         .:..|.::...|||           ||.|:
  Fly  6372 PNSANLEWHPPDDCG---------GKPITGYIVERRER-----------GGEWI 6405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNXB	NP_001352205.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..189
		EGF_2	189..213	CDD:285248
		EGF_2	216..244	CDD:285248
		VSP	<254..669	CDD:333463
		EGF_2	621..647	CDD:285248
		fn3	762..831	CDD:306538	19/78 (24%)
		fn3	843..919	CDD:306538	12/91 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	926..956		11/42 (26%)
		fn3	1061..1141	CDD:306538	23/94 (24%)
		FN3	1156..1238	CDD:238020	20/110 (18%)
		fn3	1265..1342	CDD:306538	20/81 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1372		7/31 (23%)
		fn3	1376..1446	CDD:306538	17/75 (23%)
		fn3	1475..1555	CDD:306538	20/94 (21%)
		fn3	1578..1643	CDD:306538	22/71 (31%)
		Cell attachment site. /evidence=ECO:0000255	1666..1668		0/3 (0%)
		fn3	1672..1739	CDD:306538	15/73 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1752..1777		9/80 (11%)
		FN3	1773..1862	CDD:238020	20/95 (21%)
		fn3	1885..1955	CDD:306538	15/166 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1990		5/21 (24%)
		fn3	1988..2061	CDD:306538	18/79 (23%)
		fn3	2099..2169	CDD:306538	19/75 (25%)
		fn3	2198..2268	CDD:306538	28/169 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2281..2304		3/23 (13%)
		fn3	2304..2377	CDD:306538	18/85 (21%)
		fn3	2418..2485	CDD:306538	14/70 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2495..2542		13/50 (26%)
		fn3	2526..2596	CDD:306538	13/95 (14%)
		fn3	2629..2709	CDD:306538	21/86 (24%)
		fn3	2743..2810	CDD:306538	14/72 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2824..2847		12/71 (17%)
		fn3	2845..2925	CDD:306538	14/83 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2933..2969		11/36 (31%)
		fn3	2959..3026	CDD:306538	14/71 (20%)
		fn3	3061..3134	CDD:306538	12/85 (14%)
		fn3	3170..3240	CDD:306538	21/80 (26%)
		fn3	3263..3328	CDD:306538	18/70 (26%)
		fn3	3354..3436	CDD:306538	21/86 (24%)
		fn3	3453..3515	CDD:306538	16/66 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3536..3559		11/79 (14%)
		fn3	3562..3637	CDD:306538	21/158 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3636..3662		9/31 (29%)
		fn3	3656..3738	CDD:306538	19/102 (19%)
		fn3	3758..3836	CDD:306538	21/88 (24%)
		FN3	3845..3931	CDD:238020	23/177 (13%)
		fn3	3935..4012	CDD:306538	21/121 (17%)
		Fibrinogen_C	4026..4235	CDD:278572	11/47 (23%)
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020	20/82 (24%)
		I-set	2311..2395	CDD:254352	19/117 (16%)
		Ig	2321..2395	CDD:299845	16/96 (17%)
		FN3	2399..2493	CDD:238020	26/122 (21%)
		FN3	2501..2590	CDD:238020	28/112 (25%)
		I-set	2602..2693	CDD:254352	18/114 (16%)
		Ig	2619..2693	CDD:299845	18/97 (19%)
		FN3	2697..2793	CDD:238020	28/116 (24%)
		FN3	2801..2893	CDD:238020	23/100 (23%)
		I-set	2902..2995	CDD:254352	21/97 (22%)
		Ig	2919..2993	CDD:299845	17/75 (23%)
		FN3	2999..3088	CDD:238020	26/90 (29%)
		FN3	3102..3191	CDD:238020	17/94 (18%)
		I-set	3208..3292	CDD:254352	7/83 (8%)
		Ig	3219..3292	CDD:299845	7/72 (10%)
		FN3	3296..3390	CDD:238020	23/106 (22%)
		FN3	3400..3489	CDD:238020	13/91 (14%)
		I-set	3494..3590	CDD:254352	9/99 (9%)
		Ig	3516..3590	CDD:299845	7/77 (9%)
		FN3	3594..3682	CDD:238020	25/110 (23%)
		FN3	3694..3781	CDD:238020	22/89 (25%)
		I-set	3795..3885	CDD:254352	6/89 (7%)
		Ig	3813..3885	CDD:299845	5/71 (7%)
		FN3	3889..3980	CDD:238020	10/90 (11%)
		FN3	3990..4082	CDD:238020	21/95 (22%)
		I-set	4090..4181	CDD:254352	24/115 (21%)
		Ig	4108..4181	CDD:299845	19/88 (22%)
		FN3	4185..4271	CDD:238020	25/98 (26%)
		FN3	4285..4383	CDD:238020	19/107 (18%)
		Ig	4404..4480	CDD:299845	10/75 (13%)
		FN3	4484..4571	CDD:238020	23/90 (26%)
		FN3	4584..4677	CDD:238020	20/105 (19%)
		I-set	4685..4775	CDD:254352	9/89 (10%)
		Ig	4703..4775	CDD:299845	8/71 (11%)
		FN3	4779..4863	CDD:238020	22/101 (22%)
		FN3	4879..4970	CDD:238020	25/101 (25%)
		IG	4989..5069	CDD:214652	15/92 (16%)
		Ig	4996..5069	CDD:299845	14/85 (16%)
		FN3	5073..5166	CDD:238020	27/111 (24%)
		FN3	5175..5265	CDD:238020	21/91 (23%)
I-set	5276..5366	CDD:254352	6/89 (7%)
Ig	5293..5366	CDD:299845	6/72 (8%)
FN3	5370..5462	CDD:238020	23/95 (24%)
FN3	5470..5561	CDD:238020	19/90 (21%)
Ig	5559..5654	CDD:299845	12/94 (13%)
I-set	5570..5660	CDD:254352	11/89 (12%)
FN3	5664..5755	CDD:238020	13/94 (14%)
FN3	5764..5853	CDD:238020	21/98 (21%)
I-set	5865..5954	CDD:254352	18/96 (19%)
Ig	5882..5954	CDD:299845	17/79 (22%)
FN3	5958..6049	CDD:238020	23/90 (26%)
FN3	6062..6153	CDD:238020	11/90 (12%)
I-set	6173..6255	CDD:254352	12/81 (15%)
Ig_Titin_like	6182..6255	CDD:143225	12/72 (17%)
FN3	6259..6350	CDD:238020	19/91 (21%)
FN3	6359..6451	CDD:238020	13/67 (19%)
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000