DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TNXB and CG9500

DIOPT Version :9

Sequence 1:	NP_001352205.1	Gene:	TNXB / 7148	HGNCID:	11976	Length:	4244	Species:	Homo sapiens
Sequence 2:	NP_609018.3	Gene:	CG9500 / 33888	FlyBaseID:	FBgn0031804	Length:	292	Species:	Drosophila melanogaster

Alignment Length:	229	Identity:	73/229 - (31%)
Similarity:	119/229 - (51%)	Gaps:	13/229 - (5%)

- Green bases have known domain annotations that are detailed below.

Human  4014 STSFTTGGLRIPFPRDCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDG 4078
            |:...|.||...:|..|    .....|....|:.:.|  .:|..|.||.|..|.||.|..||...
  Fly    65 SSDLNTTGLSGRYPSQC----PTYPPAHGIYTVQVLG--LKPFQVSCDAEIAGTGWTVMARRTSN 123

Human  4079 QTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSMRVDLRAGD-EAVFAQYDSFHVDSAA 4142
            :.:|:|.|.:|.:|||.:.|:|::|.:.||::|::..:.:.:.|...: :..:|.||...::|..
  Fly   124 KLNFFRSWAEYKNGFGQLDGDFFIGLDKLHAITKSQPHELYIHLEDFEGQTRYAHYDEIFIESEN 188

Human  4143 EYYRL-HLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLY-- 4204
            ::|.: .|..:.|.|||||.::....||..|||.:....:||..|.||||:.||.|:||.|:|
  Fly   189 KFYAMTKLGEFTGDAGDSMIHNRNQNFSTFDRDNDGWHKNCAEEYVGAWWHLNCTYSNLFGIYVK 253

Human  4205 ---GSTVDHQGVSWYHWKGFEFSVPFTEMKLRPR 4235
               |.....:|:.|:.|:...:|....:|.:||:
  Fly   254 GDEGQYFQWKGIVWHSWRTESYSYKVMQMMVRPK 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNXB	NP_001352205.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..189
		EGF_2	189..213	CDD:285248
		EGF_2	216..244	CDD:285248
		VSP	<254..669	CDD:333463
		EGF_2	621..647	CDD:285248
		fn3	762..831	CDD:306538
		fn3	843..919	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	926..956
		fn3	1061..1141	CDD:306538
		FN3	1156..1238	CDD:238020
		fn3	1265..1342	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1372
		fn3	1376..1446	CDD:306538
		fn3	1475..1555	CDD:306538
		fn3	1578..1643	CDD:306538
		Cell attachment site. /evidence=ECO:0000255	1666..1668
		fn3	1672..1739	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1752..1777
		FN3	1773..1862	CDD:238020
		fn3	1885..1955	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1990
		fn3	1988..2061	CDD:306538
		fn3	2099..2169	CDD:306538
		fn3	2198..2268	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2281..2304
		fn3	2304..2377	CDD:306538
		fn3	2418..2485	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2495..2542
		fn3	2526..2596	CDD:306538
		fn3	2629..2709	CDD:306538
		fn3	2743..2810	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2824..2847
		fn3	2845..2925	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2933..2969
		fn3	2959..3026	CDD:306538
		fn3	3061..3134	CDD:306538
		fn3	3170..3240	CDD:306538
		fn3	3263..3328	CDD:306538
		fn3	3354..3436	CDD:306538
		fn3	3453..3515	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3536..3559
		fn3	3562..3637	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3636..3662
		fn3	3656..3738	CDD:306538
		fn3	3758..3836	CDD:306538
		FN3	3845..3931	CDD:238020
		fn3	3935..4012	CDD:306538
		Fibrinogen_C	4026..4235	CDD:278572	68/215 (32%)
CG9500	NP_609018.3	FReD	76..287	CDD:238040	68/216 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710