DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNS1 and tns1b

DIOPT Version :9

Sequence 1:	XP_024308847.1	Gene:	TNS1 / 7145	HGNCID:	11973	Length:	2005	Species:	Homo sapiens
Sequence 2:	XP_021334702.1	Gene:	tns1b / 555362	ZFINID:	ZDB-GENE-030131-6933	Length:	1829	Species:	Danio rerio

Alignment Length:	2096	Identity:	1038/2096 - (49%)
Similarity:	1246/2096 - (59%)	Gaps:	404/2096 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    12 PEDLEAPKTHRFKVKTFKKVKPCGICRQVITQEGCTCKVCSFSCHRKCQAKVAAPCVPPSNHELV 76
            ||:.||..:|.|::|||||.|.||:|:|.:..||..|:||..:|||||:.||::.|||.:|:||
Zfish    36 PEEFEAVHSHTFRLKTFKKGKHCGVCKQTVNNEGLICRVCRLACHRKCEVKVSSSCVPVANYEL- 99

Human    77 PITTENAPKNVVDKGEGASRGGNTRKSLEDNGSTRVTPSVQPHLQPIRNMSVSRTMEDSCELDLV 141
                  ||.|.:           ..|.:|..|||:.:.|::...:|.|::|:.:.||::.|:|||
Zfish   100 ------APSNEL-----------PLKHIETTGSTKSSKSMESRRRPSRSLSLIQAMEENYEVDLV 147

Human   142 YVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPD 206
            |:|||||:|:|||.|.|.::.:|::|||.||:||||.|||||||||:|.||:||:.|||:|||||
Zfish   148 YITERIISVTFPSNAEEPSYSANIKEVANMLRSKHGDNYLLFNLSEKRLDISKLNPKVLDFGWPD 212

Human   207 LHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAM 271
            .|.|||:||||||||||||:||..|||||:||||||||.|||:||||||||||||||||||||||
Zfish   213 HHAPALDKICSICKAMDTWMNAGSHNVVVIHNKGNRGRTGVVVAAYMHYSNISASADQALDRFAM 277

Human   272 KRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQ 336
            |||||||::|:|||||||||.||||||||.||:||||||||||||||||||||||||||||:|||
Zfish   278 KRFYEDKVLPVGQPSQRRYVQYFSGLLSGHIKINNKPLFLHHVIMHGIPNFESKGGCRPFLKIYQ 342

Human   337 AMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDL 401
            ||||||||||||:.||||||:|||||||||||||||||||||:||||.|||||||||||||:|||
Zfish   343 AMQPVYTSGIYNVQGDSQTSICITIEPGLLLKGDILLKCYHKRFRSPCRDVIFRVQFHTCAVHDL 407

Human   402 GVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWDSYDN 466
            |:||||::||:.|||||||||||||||||:||||||||:||||||||||||||.|.|||||||:|
Zfish   408 GIVFGKDELDETFKDDRFPEYGKVEFVFSFGPEKIQGMDHLENGPSVSVDYNTQDALIRWDSYEN 472

Human   467 FSGHRDDGMEGAVRSDFDMKAQSFSALSFFPAFLSLSAHCLRTFEKQMGAPHVMQRQKGPRVVPW 531
            |:...:|.||..:
Zfish   473 FNQRCEDSMEDVI---------------------------------------------------- 485

Human   532 LLSAMQACASWFGGLCIKVVGHTQGPLDGSLYAKVKKKDSLHGST------GAVNATRPTLSATP 590
                                 ||:|||||||||||:||:||.|..      .|.:.|.|.:..|.
Zfish   486 ---------------------HTEGPLDGSLYAKVRKKESLEGGVTANGLPAAADHTLPAVDHTL 529

Human   591 NHVEHTLSVSSDSGNSTASTKTDKTDE----PVPGASSATAALSPQEKRELDRLLSGFGLEREKQ 651
            ..|:|.|||||||||||||.|||:|||    |...:..::..|||:||:|||:|||  |||
Zfish   530 PPVDHALSVSSDSGNSTASIKTDRTDEASHQPALVSQPSSQPLSPEEKQELDQLLS--GLE---- 588

Human   652 GAMYHTQHLRSRPAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELP-NQDGHSAGSMGT 715
             |..|....:|.|.||........|:|||||||||.: ..:||||||||:|| :|:|:|..|:||
Zfish   589 -APMHRTGYQSSPGGGGGGGGGVLHLVPAQVHVNGHS-NIDRETDILDDDLPISQEGNSVDSLGT 651

Human   716 LSSLDGVTNTSEGGYPEALSPLTNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAP-MRPSY 779
            |||.:|....:               |..|..|.::||...||...|    .|.....| :..|.
Zfish   652 LSSFEGRATPA---------------DLYYQSETVINGQDMPYLEKS----VHEKMLEPRVHSSS 697

Human   780 SAQEGLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQ-----LPPAPVRGGSSREA 839
            |.||.|.               ..|.||:....::||||.. |.|.     :|.||.|..|||:|
Zfish   698 SVQEHLG---------------APSGYANQNGNIYRSQSLG-ATPNTDQKYMPKAPARTTSSRDA 746

Human   840 VQRGLNSWQQQQQQQQQPRPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQQEIEQ 904
            ||| ||.|    ||...|..|            |....:..|:.::  .||||||:.||||||||
Zfish   747 VQR-LNVW----QQFGVPEVP------------VTDGVTFNPVLQS--HSLPEFPQMASQQEIEQ 792

Human   905 SIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYIPSG-- 967
            |||.||||||||:||....|  ||.|.|....|.  :::|| |.|..|:.|..|:.:.....|
Zfish   793 SIEALNMLMLDLDPALTQVP--KSHSAPSGESGV--VTTQP-SFSQTQARPSYQADTAIHDRGAA 852

Human   968 HSLGTPEPAPRASLESVPPGRSYSPYDYQPCLAGPNQDFHS----KSPAS-SSLPA--------- 1018
            .|:|.|....:.:.|...|    :....:|.....:.:|.|    ::|.| |::|:
Zfish   853 SSMGFPLTFQQVTGEPSQP----TMKQQKPTTTSQHVEFASEAGGQAPMSQSTVPSSTFGVLQLK 913

Human  1019 ---FLP--TTHSPPGPQQPPASLPGLTAQPLLSPKEATSDPSRTPEEEPLNLEGLVAHRVAAYNA 1078
               ..|  ||...|.||:...|... ::.||  |||:      .||:....||||||||||.|.|
Zfish   914 PLNIYPSSTTSQSPEPQETQRSYSS-SSSPL--PKES------EPEDSSYKLEGLVAHRVAEYTA 969

Human  1079 RLQGIGHSGSFPPPPLHRLQSSSLSGVQAREKQPAEPPAPLRRRAASDGQYENQSPEATSPRSPG 1143
            |::.|..|.|.|... ||.:|.|.||:.:.|..|.|...|.|.|..|:|..:::||    .|...
Zfish   970 RIRCINDSQSAPEFG-HRRRSLSFSGLPSGEMSPDEAAVPGRCRTLSEGLSQDESP----TRGSS 1029

Human  1144 VRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPP---------------- 1192
            ||||::|:|||||.||||||||||||.|:|||:||||||:| .|.||||
Zfish  1030 VRSPIRCISPELANTIALNPGGRPKERHMHSYREAFEEMDG-GPVSPPPIVGGEVLPQTPAFPVS 1093

Human  1193 ------SGVRSPPGLAKTPLSALGLKPHNPADILLHPTGVTRRRIQPDSLSQEIIPVNLFLSFSF 1251
                  :..||||||||||||.|||||||||:|||:.||
Zfish  1094 PQTPYFNMCRSPPGLAKTPLSFLGLKPHNPAEILLNQTG-------------------------- 1132

Human  1252 FALPHLHHLPFFPASPSSHLSSRLPSEEDEGKVVVRLSEEPRSYVESVARTAVAGPRAQDSEPKS 1316
                                    ...|||        |||||||||||: |.|.|.:...:..|
Zfish  1133 ------------------------SESEDE--------EEPRSYVESVAK-AAAVPASPTYDSDS 1164

Human  1317 FSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGPRTPTQPLL 1381
            .:.||               |.|....:|||:||||                  |.|......|.
Zfish  1165 LARPA---------------GPSHAYNAPLSSSSPI------------------QNPDPVESTLA 1196

Human  1382 ESGFRSGSLGQPS-------PSAQRNYQSSSPLPT-VGSSYSSPDYSLQHFSSSPESQARA-QFS 1437
            :||....||.|.:       ||.........|.|| :..||.||            |.|.| |.:
Zfish  1197 DSGVGMNSLSQAAVDIFHFQPSEIPYQPPPPPYPTSMLGSYISP------------SPAEAMQNN 1249

Human  1438 VAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAIN---PSMAAPSSPSLSH-HQMMGPPGTGFHGS 1498
            ...:..:.|||..||.|:.::....|.|..|..|   |.:....:|:..| ..:.|.|..|.|..
Zfish  1250 TTTIQPLSGSPGTRHHTILSDMASVPNFQHRLANQDGPILGRQQAPANGHVPGIAGSPVQGRHTM 1314

Human  1499 TVSSPQSSA------ATTPG---SPSLCRHPAG-VYQVSGLHNKVAT----TPGSPSLGRHPG-- 1547
            .....|||.      ..|.|   ||.|.|.|.| ..|.|.:.|:.|:    ...||.|.|...
Zfish  1315 VSQGTQSSPILSRQYPVTQGIQSSPILSRQPMGQAVQSSPVLNRQASLNQANQSSPVLSRQQSIT 1379

Human  1548 -AHQGN-LASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQS 1610
             .:||: :.|...|.:..|.|||.||||    .|:..|||.||||..|.||:|||:|...|||||
Zfish  1380 LPNQGSPVLSRQSSLSHPSQGSPVLGRH----PSLTQGSPSLDRHPMYSGYTTPEERHGALSRQS 1440

Human  1611 SASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPT--PALPEKRRMSVGDRAGSLPN 1673
            |:||||.|||||||||||.|           .:.|.||||||.  |.||||||||..||.....:
Zfish  1441 SSSGYQPPSTPSFPVSPAGY-----------IEGAGFRQGSPAFQPQLPEKRRMSSSDRTNGGLS 1494

Human  1674 YATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEI 1738
            |.|:|||:||||:||.|:||    |.|.||||||||.:|.|.|||||..|||||||||:||||:|
Zfish  1495 YGTLNGKMSSPVSSGGSTPS----VHFFHTLPDFSKLNMCDGSPETRMNVKFVQDTSKFWYKPDI 1555

Human  1739 SREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGP 1803
            ||:|||.:||||:||||:|||||||||||||||||:|||||.....|.||:|:||||||||||.|
Zfish  1556 SRDQAINMLKDQDPGAFVIRDSHSFRGAYGLAMKVASPPPTTQPTKKAGDVTNELVRHFLIETSP 1620

Human  1804 RGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGA- 1867
            :||:||||||||.||.||||||||||.|||||||||||.|||.:||.:.:.|.|..||:|||||
Zfish  1621 KGVRLKGCPNEPYFGCLSALVYQHSITPLALPCKLVIPTRDPLEESPEIATPTNPAADMLKQGAG 1685

Human  1868 --------ACNVLFVNSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRK 1924
                    |||||::||||||||||||||:||.|||:.|.|.|:|||||||||||||||||||||
Zfish  1686 QKSSADGHACNVLYINSVDMESLTGPQAIAKAISETMNASPAPSATIVHFKVSAQGITLTDNQRK 1750

Human  1925 LFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASA 1989
            ||||||||:.||||||:|||||||.|.|||. ||.||||||||||||||..|||||:||:|||:|
Zfish  1751 LFFRRHYPIGTVTFCDIDPQERKWNKPEGGT-AKFFGFVARKQGSTTDNVSHLFAEMDPDQPATA 1814

Human  1990 IVNFVSKVMLNAGQKR 2005
            |||||||||::: |||
Zfish  1815 IVNFVSKVMISS-QKR 1829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNS1	XP_024308847.1	None
tns1b	XP_021334702.1	C1	45..91	CDD:237996	24/45 (53%)
		PTPc_motif	208..323	CDD:214649	99/114 (87%)
		PTEN_C2	310..436	CDD:313607	112/125 (90%)
		Atrophin-1	<806..1199	CDD:331285	172/508 (34%)
		Herpes_ICP4_C	1140..>1534	CDD:332854	175/458 (38%)
		SH2_Tensin_like	1546..1661	CDD:198181	91/114 (80%)
		PTB_tensin	1692..1824	CDD:269924	108/132 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327181
Domainoid	1	1.000	656	1.000	Domainoid score	I1364
eggNOG	1	0.900	-	-		E2759_KOG1930
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11219
Inparanoid	1	1.050	1626	1.000	Inparanoid score	I762
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46687
OrthoDB	1	1.010	-	-		D172407at2759
OrthoFinder	1	1.000	-	-		FOG0011796
OrthoInspector	1	1.000	-	-		oto43792
orthoMCL	1	0.900	-	-		OOG6_103416
Panther	1	1.100	-	-	LDO	PTHR45734
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300