DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNS1 and aux

DIOPT Version :9

Sequence 1:	XP_024308847.1	Gene:	TNS1 / 7145	HGNCID:	11973	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	159/764 - (20%)
Similarity:	258/764 - (33%)	Gaps:	248/764 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    96 RG--GNTRKSLEDNGSTRVTPSVQPHLQPIRNMSVSRTMEDSCELDLVYVTERIIAVSFPSTANE 158
            ||  |...|:::|. ||:|..::|..|  .||           :||:.::|.||:.:..||...|
  Fly   382 RGGAGTLLKNIKDT-STKVMQTMQQSL--ARN-----------DLDISHITSRILVMPCPSDGFE 432

Human   159 ENFR-SNLREVAQMLKSKHGGNYL-LFNLSERR-----PDITKLHAKVLEFGWPDLHTPALEKIC 216
            ..:: :|:.:|...|:|:.....| ::|..:|.     |.:..:.|..: :|.|..|.|.|:.:.
  Fly   433 STYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSV-YGCPQAHAPNLQGLF 496

Human   217 SICKAMDTWLNADPHNVVVLHNKGNRG-RIGVVIAAYMHYSNISASADQALDRFAMKRFYEDKIV 280
            ::...|..:|||||.:||::....:.| ....||.|.:.|:::....:.|:..||:||...:.
  Fly   497 TVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINL-- 559

Human   281 PIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHH-------VIMHGIPNF-ESKGGCRPFLRIY-- 335
               :||:.||::||..:|..:      ||..|:       :....:|.. :::.|||.::.:|
  Fly   560 ---RPSEFRYLYYFGDILRPT------PLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCN 615

Human   336 -----QAMQPVYTSGIYNI-PGDSQTSVCITIEPGLLLKGDILLKCYH--KKFRSPARDVIFRVQ 392
                 ..:|......:|.. ||.      |.:...|...||:.:..:|  |....|....|.:.|
  Fly   616 GNLLLSTLQDYEKMRLYQAGPGK------IVLPINLTACGDVTVVLFHARKGMVRPQGLKICQFQ 674

Human   393 FHTCAI--HDLGVVFGKEDLDD-----------------AFKDDRFPEYGKVEFVFSYGPEK--- 435
            |:|..|  .:..:.|..:||||                 |..|...|...|..::    |.|
  Fly   675 FNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWM----PAKPKR 735

Human   436 ---------IQGMEHLEN-----------GPSVSVDYNTSDPLIRWD------------------ 462
                     ::..|.|:|           .|........|.||:..|
  Fly   736 SPAALFSSDLEYAEMLDNFVTKPSTRSSPPPGARKSDRVSSPLVLPDVTETAHELPSPMPEPSPP 800

Human   463 ----------------------------SYDNFSGHRDDGMEG--------------------AV 479
                                        |:|......||...|                    .:
  Fly   801 IDLLNLNQQPSDVPAADPLTSAKPSTDASFDLLGAFGDDDSTGIGSAPIPDILPPPPLQQPQPKI 865

Human   480 RSD-FDMKAQSFSAL----------SFFPAFLSLSAHCLRTFEKQMGAPHVMQRQKGPRVVPWLL 533
            .:| ||:    |.::          |.||.|:.    .|.||..|..|          ...|...
  Fly   866 NNDPFDI----FGSVDQGGVPSMKPSGFPPFVG----SLPTFVAQPAA----------TTNPSPT 912

Human   534 SAMQACASWFGGLCIKVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSATPNHVEHTLS 598
            ...:|.|..|..:.....|     |:.:.     .:.:|.|.:....:.:||..::|.|     .
  Fly   913 HPARASADPFANIADLATG-----LNLNF-----NRSTLSGKSPVNTSPQPTQFSSPTH-----K 962

Human   599 VSSDSGNSTASTKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQGAMYHTQHLRSR 663
            .|..|........|..|.:.:|..||......||......|             ..|...|..|:
  Fly   963 PSPSSQPQATFMHTPPTPQTLPSTSSIRTPTQPQAVPAQSR-------------PDYSRLHFDSQ 1014

Human   664 PAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELPNQDGHSAGS 712
            .|              ||....||:..|:...|||     .|.|:|.||
  Fly  1015 KA--------------AQQPGTGGSKNSDIFADIL-----GQQGYSFGS 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNS1	XP_024308847.1	None
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	27/135 (20%)
		DnaJ	<1110..1150	CDD:197617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810