DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNS1 and Tns1

DIOPT Version :9

Sequence 1:	XP_024308847.1	Gene:	TNS1 / 7145	HGNCID:	11973	Length:	2005	Species:	Homo sapiens
Sequence 2:	XP_038939258.1	Gene:	Tns1 / 301509	RGDID:	68427	Length:	1937	Species:	Rattus norvegicus

Alignment Length:	2017	Identity:	1645/2017 - (81%)
Similarity:	1720/2017 - (85%)	Gaps:	149/2017 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     9 MLWPEDLEAPKTHRFKVKTFKKVKPCGICRQVITQEGCTCKVCSFSCHRKCQAKVAAPCVPPSNH 73
            :|.||||||||||.||||.||||||||:|||.||:|||.||||||||||||||||||||||||:|
  Rat    50 LLQPEDLEAPKTHHFKVKAFKKVKPCGVCRQAITREGCICKVCSFSCHRKCQAKVAAPCVPPSSH 114

Human    74 ELVPITTENAPKNVVDKGEGASRGGNTRKSLEDNGSTRVTPSVQPHLQP-------IRNMSVSRT 131
            |||||.||:.||||||.|||..|||:|.|:||:.||.||:||:||..||       .||:||||.
  Rat   115 ELVPIATESVPKNVVDVGEGDCRGGSTPKNLEEAGSMRVSPSIQPQPQPQPQPISLSRNLSVSRA 179

Human   132 MEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLH 196
            |||||||||||:||||||||||||||||||||||||||||||||||||||||||||:||||||||
  Rat   180 MEDSCELDLVYITERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSEQRPDITKLH 244

Human   197 AKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISAS 261
            |||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   245 AKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISAS 309

Human   262 ADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKG 326
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   310 ADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKG 374

Human   327 GCRPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRV 391
            ||||||||||||||||||||||||||||.|:||||||||||||||||||||||||||||||||||
  Rat   375 GCRPFLRIYQAMQPVYTSGIYNIPGDSQASICITIEPGLLLKGDILLKCYHKKFRSPARDVIFRV 439

Human   392 QFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSD 456
            ||||||||||||||||||||:||||||||:|||||||||||||||||||||||||||||||||||
  Rat   440 QFHTCAIHDLGVVFGKEDLDEAFKDDRFPDYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSD 504

Human   457 PLIRWDSYDNFSGHRDDGMEGAVRSDFDMKAQSFSALSFFPAFLSLSAHCLRTFEKQMGAPHVMQ 521
            |||||||||||:|||:||||
  Rat   505 PLIRWDSYDNFNGHREDGME--------------------------------------------- 524

Human   522 RQKGPRVVPWLLSAMQACASWFGGLCIKVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTL 586
                                       :|||||||||||||||||||||||:||:|.:...||.|
  Rat   525 ---------------------------EVVGHTQGPLDGSLYAKVKKKDSLNGSSGPITTARPAL 562

Human   587 SATPNHVEHTLSVSSDSGNSTASTKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQ 651
            |||||||||||||||||||||||||||||||||.||:.|.||||||||:||||||||||::||||
  Rat   563 SATPNHVEHTLSVSSDSGNSTASTKTDKTDEPVSGAAIAPAALSPQEKKELDRLLSGFGVDREKQ 627

Human   652 GAMYHTQHLRSRPAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELPNQDGHSAGSMGTL 716
            ||||..|.|||.|.||..|.|.|||:||||||||||||||||||||||||||.|||.|.||||||
  Rat   628 GAMYRAQQLRSHPGGGPTVSSPGRHIVPAQVHVNGGALASERETDILDDELPIQDGQSGGSMGTL 692

Human   717 SSLDGVTNTSEGGYPEALSPLTNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAPMRPSYSA 781
            ||||||||||||||||.||||||||||.||.||::||||||||||:|..|.|:.|:||:||||||
  Rat   693 SSLDGVTNTSEGGYPETLSPLTNGLDKPYPTEPILNGGGYPYESANRVVPVHSSHSAPIRPSYSA 757

Human   782 QEGLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQLPPAPVRGGSSREAVQRGLNS 846
            ||||.|||||||||||.:.||::|..:||||:||||||.:.|||||.||.|||||||||||||||
  Rat   758 QEGLGGYQREGPHPAWSKQVTSAHRGYDPSGLFRSQSFPDVEPQLPQAPARGGSSREAVQRGLNS 822

Human   847 W------------QQQQQQQQQPRPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQ 899
            |            ||||||||||.||||||||:.|:||..|:|||...||||||:||||||||||
  Rat   823 WQQQQQQQQQQQQQQQQQQQQQPHPPPRQQERSPLQSLACSKPSPHLSAETPIPALPEFPRAASQ 887

Human   900 QEIEQSIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYI 964
            |||||||||||||||||||||||||||||||||||||||||||||||.|||.|||||||||||||
  Rat   888 QEIEQSIETLNMLMLDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLLGSSCQSHPLTQSRSGYI 952

Human   965 PSGHSLGTPEPAPRASLESVPPGRSYSPYDYQPCLAGPNQDFHSKSPASSSLPAFLPTTHSPPGP 1029
            |||.:||.|        |.:..||||||||||...|..||.|..||||||:   |||:.||..||
  Rat   953 PSGDTLGAP--------ELLSSGRSYSPYDYQLHPAASNQSFRPKSPASST---FLPSPHSSAGP 1006

Human  1030 QQPPASLPGLTAQPLLSPKEATSDPSRTPEEEPLNLEGLVAHRVAAYNARLQGIGHSGSFPPPPL 1094
            |:||||||||.|:|.|..||.|||.||||||||||||||||||||.||||||.:..|.| ..|.|
  Rat  1007 QEPPASLPGLIAEPQLPLKETTSDTSRTPEEEPLNLEGLVAHRVAVYNARLQSLRQSSS-SRPSL 1070

Human  1095 HRLQSSSLSGVQAREKQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTI 1159
            |||:|:|||.|||||:|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1071 HRLRSASLSRVQARERQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTI 1135

Human  1160 ALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPT 1224
            ||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||||
  Rat  1136 ALNPGGRPKEPHLHSYKEAFEEMEGTSPSSPPPSVARSPPGLAKTPLSALGLKPHNPADILLHPT 1200

Human  1225 GVTRRRIQPDSLSQEIIPVNLFLSFSFFALPHLHHLPFFPASPSSHLSSRLPSEEDEGKVVVRLS 1289
            ||.||.|||                                            |||||:.|.:..
  Rat  1201 GVARRLIQP--------------------------------------------EEDEGEEVAKPP 1221

Human  1290 EEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILS 1354
            ||||||||||||||||||||||.||||||||||.|||||.||||||.||||||||||||||||||
  Rat  1222 EEPRSYVESVARTAVAGPRAQDVEPKSFSAPATHAYGHETPLRNGTPGGSFVSPSPLSTSSPILS 1286

Human  1355 ADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDY 1419
            |||||||||||..|||||||||.||:|:|..||||||||||:| .:||||||:|..|||||||||
  Rat  1287 ADSTSVGSFPSAGSSDQGPRTPIQPMLDSSIRSGSLGQPSPAA-LSYQSSSPVPVGGSSYSSPDY 1350

Human  1420 SLQHFSSSPESQARAQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSH 1484
            |||.||||||||.:..||.|.||.|||||||||||||||||||||||.|||||:||||.||||||
  Rat  1351 SLQPFSSSPESQGQPHFSAASVHMVPGSPQARHRTVGTNTPPSPGFGRRAINPTMAAPGSPSLSH 1415

Human  1485 HQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNKVATTPGSPSLGRHPGAH 1549
            .|:|||.|.||||:.||...:||...||||||.|||.|.:||.|||:.|.|||||||||||||||
  Rat  1416 RQVMGPSGPGFHGNVVSGHPTSATVAPGSPSLGRHPVGSHQVPGLHSGVVTTPGSPSLGRHPGAH 1480

Human  1550 QGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASG 1614
            ||||.|.||.||:.||||||||||||||||||||||.||||||||||||||||||||||||||||
  Rat  1481 QGNLVSSLHGNAVISPGSPSLGRHLGGSGSVVPGSPSLDRHVAYGGYSTPEDRRPTLSRQSSASG 1545

Human  1615 YQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATING 1679
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1546 YQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATING 1610

Human  1680 KV-SSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQA 1743
            || |||||:||:||||.||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1611 KVSSSPVANGMASPSGSSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQA 1675

Human  1744 IALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKL 1808
            |||||||||||||||||||||||||||||||||||||.||.||||||||||||||||||||||||
  Rat  1676 IALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTITQQGKKGDMTHELVRHFLIETGPRGVKL 1740

Human  1809 KGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLF 1873
            ||||||||||||||||||||:||||||||||||:|||||||||||||||||.|||||||||||||
  Rat  1741 KGCPNEPNFGSLSALVYQHSVIPLALPCKLVIPSRDPTDESKDSSGPANSTTDLLKQGAACNVLF 1805

Human  1874 VNSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTF 1938
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1806 INSVDMESLTGPQAISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTF 1870

Human  1939 CDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLNAGQ 2003
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat  1871 CDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLSAGQ 1935

Human  2004 KR 2005
            ||
  Rat  1936 KR 1937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNS1	XP_024308847.1	None
Tns1	XP_038939258.1	C1_TNS1_v	57..112	CDD:410438	48/54 (89%)
		PTP_DSP_cys	187..345	CDD:421693	154/157 (98%)
		PTEN_C2	352..478	CDD:402161	121/125 (97%)
		PHA03247	<718..1143	CDD:223021	331/436 (76%)
		PHA03247	<1091..1643	CDD:223021	482/596 (81%)
		SH2_Tensin_like	1661..1776	CDD:198181	110/114 (96%)
		PTB_tensin	1798..1931	CDD:269924	131/132 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83679884
Domainoid	1	1.000	1943	1.000	Domainoid score	I294
eggNOG	1	0.900	-	-		E2759_KOG1930
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11219
Inparanoid	1	1.050	3094	1.000	Inparanoid score	I481
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46687
OrthoDB	1	1.010	-	-		D14319at32523
OrthoFinder	1	1.000	-	-		FOG0011796
OrthoInspector	1	1.000	-	-		oto142749
orthoMCL	1	0.900	-	-		OOG6_103416
Panther	1	1.100	-	-	LDO	PTHR45734
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270