DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNS1 and Tns1

DIOPT Version :9

Sequence 1:	XP_024308847.1	Gene:	TNS1 / 7145	HGNCID:	11973	Length:	2005	Species:	Homo sapiens
Sequence 2:	XP_006495930.2	Gene:	Tns1 / 21961	MGIID:	104552	Length:	1922	Species:	Mus musculus

Alignment Length:	2003	Identity:	1648/2003 - (82%)
Similarity:	1720/2003 - (85%)	Gaps:	140/2003 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     9 MLWPEDLEAPKTHRFKVKTFKKVKPCGICRQVITQEGCTCKVCSFSCHRKCQAKVAAPCVPPSNH 73
            ::.||||||||||.||||.||||||||||||.||:|||.||||||||||||||||||||||||:|
Mouse    54 LVLPEDLEAPKTHHFKVKAFKKVKPCGICRQAITREGCVCKVCSFSCHRKCQAKVAAPCVPPSSH 118

Human    74 ELVPITTENAPKNVVDKGEGASRGGNTRKSLEDNGSTRVTPSV--QPHLQPI---RNMSVSRTME 133
            ||||||||..||||||.|||..|.|::.|:||:.||.||:||:  ||..||.   ||.||||.||
Mouse   119 ELVPITTETVPKNVVDVGEGDCRVGSSPKNLEEGGSMRVSPSIQPQPQSQPTSLSRNTSVSRAME 183

Human   134 DSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAK 198
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Mouse   184 DSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSEQRPDITKLHAK 248

Human   199 VLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASAD 263
            |||||||||||||||||||:||||||||||||||||||||||||||||||||||:||||||||||
Mouse   249 VLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYLHYSNISASAD 313

Human   264 QALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGC 328
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   314 QALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGC 378

Human   329 RPFLRIYQAMQPVYTSGIYNIPGDSQTSVCITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQF 393
            ||||||||||||||||||||||||||.|:||||||||||||||||||||||||||||||||||||
Mouse   379 RPFLRIYQAMQPVYTSGIYNIPGDSQASICITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQF 443

Human   394 HTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPL 458
            ||||||||||||||||||:||||||||:|||||||||||||||||||||||||||||||||||||
Mouse   444 HTCAIHDLGVVFGKEDLDEAFKDDRFPDYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPL 508

Human   459 IRWDSYDNFSGHRDDGMEGAVRSDFDMKAQSFSALSFFPAFLSLSAHCLRTFEKQMGAPHVMQRQ 523
            |||||||||||||:|||||
Mouse   509 IRWDSYDNFSGHREDGMEG---------------------------------------------- 527

Human   524 KGPRVVPWLLSAMQACASWFGGLCIKVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNATRPTLSA 588
                                    :||||||||||||||||||||||||:||:|.|...||.|||
Mouse   528 ------------------------LKVVGHTQGPLDGSLYAKVKKKDSLNGSSGPVTTARPALSA 568

Human   589 TPNHVEHTLSVSSDSGNSTASTKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQGA 653
            |||||||||||||||||||||||||||||||.||::|.||||||||:||||||||||::||||||
Mouse   569 TPNHVEHTLSVSSDSGNSTASTKTDKTDEPVSGATTAPAALSPQEKKELDRLLSGFGVDREKQGA 633

Human   654 MYHTQHLRSRPAGGSAVPSSGRHVVPAQVHVNGGALASERETDILDDELPNQDGHSAGSMGTLSS 718
            ||..|.|||.|.||..|||.|||:||||||||||||||||||||||||||.|||.|.||||||||
Mouse   634 MYRAQQLRSHPGGGPTVPSPGRHIVPAQVHVNGGALASERETDILDDELPIQDGQSGGSMGTLSS 698

Human   719 LDGVTNTSEGGYPEALSPLTNGLDKSYPMEPMVNGGGYPYESASRAGPAHAGHTAPMRPSYSAQE 783
            |||||||||.||||.||||||||||.|..||::||||||||:|:|..|.|:.|:||:||||||||
Mouse   699 LDGVTNTSESGYPETLSPLTNGLDKPYSTEPVLNGGGYPYEAANRVIPVHSSHSAPIRPSYSAQE 763

Human   784 GLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQLPPAPVRGGSSREAVQRGLNSWQ 848
            ||||||||||||||.|.||::|...||||:||||||.:.|||||.||.||||||||||||||||
Mouse   764 GLAGYQREGPHPAWSQQVTSAHCGCDPSGLFRSQSFPDVEPQLPQAPTRGGSSREAVQRGLNSW- 827

Human   849 QQQQQQQQPRPPPRQQERAHLESLVASRPSPQPLAETPIPSLPEFPRAASQQEIEQSIETLNMLM 913
                |||||.||||||||:.|:||..|:||||..||||:.:||||||||||||||||||||||||
Mouse   828 ----QQQQPHPPPRQQERSPLQSLARSKPSPQLSAETPVAALPEFPRAASQQEIEQSIETLNMLM 888

Human   914 LDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLSGSSRQSHPLTQSRSGYIPSGHSLGTPEPAPR 978
            |||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
Mouse   889 LDLEPASAAAPLHKSQSVPGAWPGASPLSSQPLLGSSRQSHPLTQSRSGYIPSGHSLGTP----- 948

Human   979 ASLESVPPGRSYSPYDYQPCLAGPNQDFHSKSPASSSLPAFLPTTHSPPGPQQPPASLPGLTAQP 1043
               |.|..||.|||||||...||.||.||.||||||:   |||:.||..|||:||||||||.|||
Mouse   949 ---ELVSSGRPYSPYDYQLHPAGSNQSFHPKSPASST---FLPSPHSSAGPQEPPASLPGLIAQP 1007

Human  1044 LLSPKEATSDPSRTPEEEPLNLEGLVAHRVAAYNARLQGIGHSGSFPPPPLHRLQSSSLSGVQAR 1108
            .|.|||.||||||||||||||||||||||||.||||||.:..|..|.|.| |..:|:||||||||
Mouse  1008 QLPPKETTSDPSRTPEEEPLNLEGLVAHRVAVYNARLQSLRQSRGFQPSP-HWRRSASLSGVQAR 1071

Human  1109 EKQPAEPPAPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLH 1173
            |:||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1072 ERQPAEPPGPLRRRAASDGQYENQSPEATSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLH 1136

Human  1174 SYKEAFEEMEGTSPSSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGVTRRRIQPDSLSQ 1238
            ||||||||||||||||||.|..|||||||||||||||||||||||||||||||.||.|||
Mouse  1137 SYKEAFEEMEGTSPSSPPHSVARSPPGLAKTPLSALGLKPHNPADILLHPTGVARRLIQP----- 1196

Human  1239 EIIPVNLFLSFSFFALPHLHHLPFFPASPSSHLSSRLPSEEDEGKVVVRLSEEPRSYVESVARTA 1303
                                                   |||||:.|.:..||||||||||||||
Mouse  1197 ---------------------------------------EEDEGEEVTKPPEEPRSYVESVARTA 1222

Human  1304 VAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGES 1368
            ||||||||.|||||||||..|||||.||||||.|||||||||||||||||||||||||||||..|
Mouse  1223 VAGPRAQDVEPKSFSAPAAHAYGHETPLRNGTPGGSFVSPSPLSTSSPILSADSTSVGSFPSVVS 1287

Human  1369 SDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQAR 1433
            ||||||||.||:|:|..||||||||||:| .:||||||:|..||||:|||||||.||||||||.:
Mouse  1288 SDQGPRTPFQPMLDSSIRSGSLGQPSPAA-LSYQSSSPVPVGGSSYNSPDYSLQPFSSSPESQGQ 1351

Human  1434 AQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGS 1498
            .|:|.|.||.|||||||||||||||||||||||.||:||:||||.||||||.|:|||.|.||||:
Mouse  1352 PQYSAASVHMVPGSPQARHRTVGTNTPPSPGFGRRAVNPTMAAPGSPSLSHRQVMGPSGPGFHGN 1416

Human  1499 TVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNKVATTPGSPSLGRHPGAHQGNLASGLHSNAIA 1563
            .||...:|||||||||||.|||.|.:||.|||:.|.|||||||||||||||||||||.|||||:.
Mouse  1417 VVSGHPASAATTPGSPSLGRHPVGSHQVPGLHSSVVTTPGSPSLGRHPGAHQGNLASSLHSNAVI 1481

Human  1564 SPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPA 1628
            ||||||||||||||||||||||.||||.|||||||||||||||||||||||||||||||||||||
Mouse  1482 SPGSPSLGRHLGGSGSVVPGSPSLDRHAAYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPA 1546

Human  1629 YYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKV-SSPVASGMSSP 1692
            ||||||||||||||||||||||||||||||||||||||||||||||||||||| |||||:||:
Mouse  1547 YYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSSPVANGMA-- 1609

Human  1693 SGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFII 1757
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1610 SGSSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFII 1674

Human  1758 RDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSA 1822
            |||||||||||||||||||||||.||.||||||||||||||||||||||||||||||||||||||
Mouse  1675 RDSHSFRGAYGLAMKVSSPPPTITQQGKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSA 1739

Human  1823 LVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQA 1887
            ||||||:||||||||||||:|||||||||||||||||.|||||||||||||||||||||||||||
Mouse  1740 LVYQHSVIPLALPCKLVIPSRDPTDESKDSSGPANSTTDLLKQGAACNVLFVNSVDMESLTGPQA 1804

Human  1888 ISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTE 1952
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1805 ISKATSETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTE 1869

Human  1953 GGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLNAGQKR 2005
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||
Mouse  1870 GGAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLSAGQKR 1922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNS1	XP_024308847.1	None
Tns1	XP_006495930.2	C1	<79..112	CDD:381770	29/32 (91%)
		PTP_DSP_cys	189..347	CDD:391942	154/157 (98%)
		PTEN_C2	354..480	CDD:371036	121/125 (97%)
		PHA03247	<737..1233	CDD:223021	413/556 (74%)
		PHA03247	<1073..1649	CDD:223021	504/622 (81%)
		SH2_Tensin_like	1646..1761	CDD:198181	110/114 (96%)
		PTB_tensin	1783..1916	CDD:269924	132/132 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83954390
Domainoid	1	1.000	1943	1.000	Domainoid score	I340
eggNOG	1	0.900	-	-		E2759_KOG1930
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11219
Inparanoid	1	1.050	3099	1.000	Inparanoid score	I566
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46687
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0011796
OrthoInspector	1	1.000	-	-		oto126688
orthoMCL	1	0.900	-	-		OOG6_103416
Panther	1	1.100	-	-	LDO	PTHR45734
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5448
SonicParanoid	1	1.000	-	-		X1051
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.290