DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNR and Ten-m

DIOPT Version :9

Sequence 1:	NP_003276.3	Gene:	TNR / 7143	HGNCID:	11953	Length:	1358	Species:	Homo sapiens
Sequence 2:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster

Alignment Length:	1542	Identity:	298/1542 - (19%)
Similarity:	498/1542 - (32%)	Gaps:	512/1542 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   122 KKACP--CASSAQVLQ-ELLSRIEMLEREVSVLRDQCNANCCQESAATGQLDYIPHCSGHGNFSF 183
            :..||  |:...:... |.:.......:|.|:..|:|.               :..|||||:...
  Fly  1099 ESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDECE---------------VADCSGHGHCVS 1148

Human   184 ESCGCICNEGWFGKNCSEPYCP-LGCSSRGVCVDGQCI--------------------------- 220
            ..|.|:  .|:.||.|.|..|| ..||..|.|.||.||
  Fly  1149 GKCQCM--RGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGH 1211

Human   221 -----------CDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKG 274
                       |::::||||||:..|..||...|.|....|.|:..:.||.|....|...|:..|
  Fly  1212 GTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHG 1276

Human   275 RCANGTCLCEEGYVGEDCGQRQCLNACSGRGQCE---EGL--CVCEEGYQGPDCSAV-----APP 329
            :|.||||||..|:.|:.|....|.|:|:|.|||.   ||.  |.|.||:.||||...     ...
  Fly  1277 QCKNGTCLCVTGWNGKHCTIEGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDS 1341

Human   330 EDLRVAGISD------------RSIELEWDGPMAVTEYVISYQPTALGG--LQLQQRVPGDWSGV 380
            :|....|:.|            ::.:|....|..: :.::..||.|:..  .:..:.:..:.|..
  Fly  1342 KDNDKDGLVDCEDPECCASHVCKTSQLCVSAPKPI-DVLLRKQPPAITASFFERMKFLIDESSLQ 1405

Human   381 TITELEPGLTYNISVYAVISNI-LSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFS-FD 443
            ...:||   |:|.|::....|. .|..|..:|.|.|.  .||....::.||:   .|.|:.: .|
  Fly  1406 NYAKLE---TFNESIFWNYFNASRSAVIRGRVVTSLG--MGLVGVRVSTTTL---LEGFTLTRDD 1462

Human   444 GWEISFIPKNNEGGVIAQVPSDVTSFNQTGLKP---------GEEYIVN--VVALKEQARSPPTS 497
            ||   |....|.||.:      ...|.:...:|         .|..|::  |:::.|:.....|:
  Fly  1463 GW---FDLMVNGGGAV------TLQFGRAPFRPQSRIVQVPWNEVVIIDLVVMSMSEEKGLAVTT 1518

Human   498 ASVSTVIDGPTQILVRDVSDTVAFVEWIPPRAKVDFILLKYGLVGGEGGRTTFRLQPPLSQYSVQ 562
            .......|       .|:...|....|            |:|..|....|:....:..:.|.|:|
  Fly  1519 THTCFAHD-------YDLMKPVVLASW------------KHGFQGACPDRSAILAESQVIQESLQ 1564

Human   563 ALRPGSRYEVSVSAVRGTNESDSATTQFTTEIDAPKNL--------------------------- 600
            .  ||:...:...:.|......:...|.|.:: .|.:|
  Fly  1565 I--PGTGLNLVYHSSRAAGYLSTIKLQLTPDV-IPTSLHLIHLRITIEGILFERIFEADPGIKFT 1626

Human   601 ---------------------RVGSRTATSLDLEWDNSEAEVQEYKVVYSTLAG--------EQY 636
                                 :||.:.....|:.||....::..:.:..|.:.|        ..:
  Fly  1627 YAWNRLNIYRQRVYGVTTAVVKVGYQYTDCTDIVWDIQTTKLSGHDMSISEVGGWNLDIHHRYNF 1691

Human   637 HEVLVPRGIGPT------TRATLTDLVPGTEYGVGI----SAVMNSQQSVPATMNART------- 684
            ||.::.:|.|..      .|..||.:..|.:..:..    ......:...|..:.|..
  Fly  1692 HEGILQKGDGSNIYLRNKPRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAAPDGSLFVG 1756

Human   685 ELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGI-------ASEVTVPKDRTSYTLT 742
            :.:..|.:|...|..|.:.|..|:.|   ..|.:..:|..|.       :.::...:|...|:..
  Fly  1757 DFNYIRRIMTDGSIRTVVKLNATRVS---YRYHMALSPLDGTLYVSDPESHQIIRVRDTNDYSQP 1818

Human   743 DLE------------PGAEY-----IISVTAERGRQQSLESTVDAF------TGFRPI------- 777
            :|.            ||.|.     .::..|:....:.:..:.|..      |..|.:
  Fly  1819 ELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRMVDRDGIVS 1883

Human   778 ----SHLHFSH---------VTSSSVNITWSDPSPPADRLILNYSPRDEE----EEMMEVSLDAT 825
                :|:|.||         :....:::.|     |.:   |..||.|..    ::.|.:.:...
  Fly  1884 TLIGNHMHKSHWKPIPCEGTLKLEEMHLRW-----PTE---LAVSPMDNTLHIIDDHMILRMTPD 1940

Human   826 KRHAVLMGLQP------ATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKDITISNVTKDSVMVSW 884
            .|..|:.| :|      :|.|..:| |.|.|:..             |:.|            ::
  Fly  1941 GRVRVISG-RPLHCATASTAYDTDL-ATHATLVM-------------PQSI------------AF 1978

Human   885 SP----PVASFDYYRVSYRPTQVGRLDSSVVPNTVTEFTITRLNPATEYEISLNSV-RGREESER 944
            .|    .||..|..|:: |...:|              |..|:.|....|...|.: ||.:..|.
  Fly  1979 GPLGELYVAESDSQRIN-RVRVIG--------------TDGRIAPFAGAESKCNCLERGCDCFEA 2028

Human   945 ICTLVHTAMDNPVDLIATNITPTE----------------ALLQWKAPVGEVENY------VIVL 987
            ...|..:|..|.:..:|  :||..                :.:...:|..|.|.|      :.:.
  Fly  2029 EHYLATSAKFNTIAALA--VTPDSHVHIADQANYRIRSVMSSIPEASPSREYEIYAPDMQEIYIF 2091

Human   988 THFA--------VAGETILVDGVSEEFRLVDLLPSTHYTATMYATNGPLTSGTISTNFSTLL--D 1042
            ..|.        :.|||..|                 :|..:..:||.|::.|.:......|  |
  Fly  2092 NRFGQHVSTRNILTGETTYV-----------------FTYNVNTSNGKLSTVTDAAGNKVFLLRD 2139

Human  1043 PPANLTASE----------VTRQSALISWQPPRAEIENYVLTYK----------STDGSRKELIV 1087
            ..:.:.:.|          :||...|.....|    :||.:||:          ..|.:.:..:.
  Fly  2140 YTSQVNSIENTKGQKCRLRMTRMKMLHELSTP----DNYNVTYEYHGPTGLLRTKLDSTGRSYVY 2200

Human  1088 DAEDTWIRLEGLLENT-------------------------DYTVLLQAA--------------- 1112
            : .|.:.||...:..|                         :.::|:|.|
  Fly  2201 N-YDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIVRNGAAESRTTV 2264

Human  1113 -QDTTWSSITSTAFTTGGRVFPHPQDCAQHLMNGDTLSGVYPI------FLNGELSQKLQVYCDM 1170
             .|.:.:|||.........|.|:.....|..:.|::    ||:      .:.|:|:.:.:
  Fly  2265 DMDGSTTSITPWGHNLQMEVAPYTILAEQSPLLGES----YPVPAKQRTEIAGDLANRFE----- 2320

Human  1171 TTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNVEDEFWLGLDNIHRITSQGRYELRVDMRDGQE 1235
                  |..|.|||.......:.....|                  .:|..|| :|||   :|..
  Fly  2321 ------WRYFVRRQQPLQAGKQSKGPPR------------------PVTEVGR-KLRV---NGDN 2357

Human  1236 AAFASYDR------FSVEDSRNLYKLRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSY 1294
            .....|||      ..|:|.:.|..:   :|:.|:         ||.|...:..|.|..:.....
  Fly  2358 VLTLEYDRETQSVVVMVDDKQELLNV---TYDRTS---------RPISFRPQSGDYADVDLEYDR 2410

Human  1295 KG---AW-W--YKNCHRTNLNGKYGESRHSQGINW-YHWKGHEFSIP 1334
            .|   :| |  .:..:..:.||:..|.::..|... |.:|....|:|
  Fly  2411 FGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTMVYAFKDMFGSLP 2457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNR	NP_003276.3	EGF_2	<208..230	CDD:285248	12/59 (20%)
		EGF_2	267..292	CDD:285248	11/24 (46%)
		EGF_2	299..323	CDD:285248	14/28 (50%)
		fn3	328..398	CDD:278470	14/83 (17%)
		fn3	416..496	CDD:278470	19/91 (21%)
		fn3	505..583	CDD:278470	14/77 (18%)
		FN3	595..679	CDD:238020	18/149 (12%)
		fn3	687..766	CDD:278470	17/102 (17%)
		fn3	776..855	CDD:278470	21/108 (19%)
		fn3	865..944	CDD:278470	16/83 (19%)
		fn3	954..1026	CDD:278470	14/101 (14%)
		FN3	1042..1127	CDD:238020	22/145 (15%)
		FReD	1133..1342	CDD:238040	44/221 (20%)
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	30/115 (26%)
		CRD2	1106..1151	CDD:276900	11/59 (19%)
		EGF_2	1139..1162	CDD:285248	10/24 (42%)
		Keratin_B2	1162..1330	CDD:279797	57/167 (34%)
		EGF_2	1167..1194	CDD:285248	10/26 (38%)
		DUF3844	1171..>1235	CDD:289707	15/63 (24%)
		EGF_2	<1272..1294	CDD:285248	11/21 (52%)
		NHL	1750..2065	CDD:302697	64/369 (17%)
		NHL repeat	1784..1830	CDD:271320	6/45 (13%)
		NHL repeat	1854..1888	CDD:271320	3/33 (9%)
		NHL repeat	1911..1950	CDD:271320	10/47 (21%)
		NHL repeat	1972..2005	CDD:271320	10/72 (14%)
		NHL repeat	2039..2065	CDD:271320	4/27 (15%)
		RHS_repeat	2183..2218	CDD:283287	5/35 (14%)
		RhsA	2347..3020	CDD:225750	30/127 (24%)
		YD_repeat_2x	2795..2836	CDD:273728
		Rhs_assc_core	2905..2980	CDD:274730
		Tox-GHH	3193..3268	CDD:292269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810