DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNR and tnr

DIOPT Version :9

Sequence 1:	NP_003276.3	Gene:	TNR / 7143	HGNCID:	11953	Length:	1358	Species:	Homo sapiens
Sequence 2:	NP_001107287.1	Gene:	tnr / 100135076	XenbaseID:	XB-GENE-948286	Length:	1350	Species:	Xenopus tropicalis

Alignment Length:	1363	Identity:	856/1363 - (62%)
Similarity:	1074/1363 - (78%)	Gaps:	20/1363 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGADGETVVLKNMLIGINLILLGSMIKPSECQLEVT--TERVQRQSVEEEGGIANYNTSSKEQPV 63
            ||::|.:..|..:.:|::||||..:.:.|:||.|:|  |.|:..| |::.|.:.::...:|:.|:
Frog     1 MGSEGVSSALGPLQVGVHLILLACLTRRSQCQSELTGQTPRLDIQ-VDKGGNMTDHGIENKQNPM 64

Human    64 VFNHVYNINVPLDNLCSSGLEASAEQEVSAEDETLAEYMGQTSDHESQVTFTHRINFPKKACPCA 128
            |||||||.||||...|      :.|.|...:...:.:....|:|..||:||||.|..|::.|.|.
Frog    65 VFNHVYNFNVPLSFPC------TLEPETPEDGSWVTQQTENTADAGSQITFTHSIRVPQRLCQCY 123

Human   129 SSAQVLQELLSRIEMLEREVSVLRDQCNANCCQESAATGQLDYIPHCSGHGNFSFESCGCICNEG 193
            ::...:|.||||||.|||||.:||::||...||::.|||..::.|.|||||||:.:|  ||||:|
Frog   124 TTPHAVQHLLSRIEALEREVMLLRERCNDRACQDAEATGLTEFAPPCSGHGNFTVDS--CICNQG 186

Human   194 WFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTG 258
            |.|:|||||.|||.||.||.|::|.|:|:.:|:|:.|::|.||.:||..|||.||:|||::||.|
Frog   187 WGGENCSEPLCPLECSGRGTCIEGMCVCEPDYTGEWCTDLLCPEECSPHGLCQDGQCVCQDPYIG 251

Human   259 EDCRELRCPGDCSGKGRCANGTCLCEEGYVGEDCGQRQCLNACSGRGQCEEGLCVCEEGYQGPDC 323
            ..|.||||||||.||||||||||:|::||.|||||:..|:|||||||||::|:|.|||||.|.||
Frog   252 IGCTELRCPGDCLGKGRCANGTCVCQDGYAGEDCGRMWCINACSGRGQCQDGVCECEEGYSGQDC 316

Human   324 SAVAPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPTALG--GLQ--LQQRVPGDWSGVTITE 384
            |.||||.|..|..:.|..::|.|:|..|||||||||||...|  |.|  ||||||||||.|||.|
Frog   317 SEVAPPVDFSVTAVGDHWMDLAWEGTTAVTEYVISYQPAVPGEWGTQQRLQQRVPGDWSSVTIRE 381

Human   385 LEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISF 449
            ||||:||||||.:|||:|:|.|.:..::||:|:|:||.|..:|:|:|||.|:|..|..|||||||
Frog   382 LEPGVTYNISVCSVISDIISEPASITISTHISSPRGLNFMEVTQTSVEVHWDPPVFPLDGWEISF 446

Human   450 IPKNNEGGVIAQVPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTQILVRD 514
            .|||||||:..|:||.|||||||||||||||.|::::||:|||||.||.|:||.|||||.|||||
Frog   447 TPKNNEGGLTVQLPSSVTSFNQTGLKPGEEYTVSIISLKDQARSPATSGSISTDIDGPTNILVRD 511

Human   515 VSDTVAFVEWIPPRAKVDFILLKYGLVGGEGGRTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRG 579
            |:||||||||.|.|||:||:.|.||.:.|||.:|||||||||||||:|.|||||:||:|:..|||
Frog   512 VTDTVAFVEWTPARAKLDFMQLDYGPINGEGEKTTFRLQPPLSQYSMQVLRPGSQYEISIRGVRG 576

Human   580 TNESDSATTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEVQEYKVVYSTLAGEQYHEVLVPRG 644
            ..||:.....||||:||||||||.|..:::|:|||||||||.:.|:||||||||:||||::|||.
Frog   577 DTESEPVRATFTTELDAPKNLRVISHASSTLELEWDNSEAEGEGYRVVYSTLAGDQYHELIVPRN 641

Human   645 IGPTTRATLTDLVPGTEYGVGISAVMNSQQSVPATMNARTELDSPRDLMVTASSETSISLIWTKA 709
            .|.||:||||||:||||||:||||:..:.:|.|||||||||||||.|||||.|::.||||.||||
Frog   642 YGQTTKATLTDLIPGTEYGIGISAIRYNLKSAPATMNARTELDSPTDLMVTGSTDKSISLTWTKA 706

Human   710 SGPIDHYRITFTPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISVTAERGRQQSLESTVDAFTGF 774
            .||||||||:||||||:|||||||.|.:.|.|::||||.||.||:.||||||||.|:|:||||||
Frog   707 RGPIDHYRISFTPSSGMASEVTVPSDISQYELSELEPGTEYTISIFAERGRQQSKETTIDAFTGF 771

Human   775 RPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATE 839
            |||:.||||.||:.|||::|:|||||.|:.||.|:|.|.::. :::.||.:.|...|..|||:||
Frog   772 RPITQLHFSAVTAYSVNVSWTDPSPPPDQFILTYNPIDSKDP-LQLFLDPSLRQTRLSALQPSTE 835

Human   840 YIVNLVAVHGTVTSEPIVGSITTGIDPPKDITISNVTKDSVMVSWSPPVASFDYYRVSYRPTQVG 904
            |:|.|:.|||||.:|.:.|::|||:.||.|:::.|||::|:.|.|.||.:|..:||::|:.|: |
Frog   836 YMVTLLPVHGTVRAELVEGTVTTGVAPPMDLSVINVTENSLAVVWRPPPSSLHHYRLTYQSTK-G 899

Human   905 RLDSSVVPNTVTEFTITRLNPATEYEISLNSVRGREESERICTLVHTAMDNPVDLIATNITPTEA 969
            |:||.|:.|..|.:|:..|.|.|||:|||.||||||||||:..:..||:|.|..|..:|||.|||
Frog   900 RMDSVVIGNDQTRYTLANLMPNTEYKISLRSVRGREESERVGIVSWTAVDPPYGLRTSNITATEA 964

Human   970 LLQWKAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTATMYATNGPLTSGTIS 1034
            ||.|:.|..|||:|||::||.|.:||||||||.|.||:|.:|||.|:|:.|:.|..|..||.::.
Frog   965 LLHWEPPRSEVESYVIIVTHHAGSGETILVDGESIEFQLQNLLPRTNYSVTLSANFGHQTSRSVG 1029

Human  1035 TNFSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTDGSRKELIVDAEDTWIRLEGL 1099
            .:|:|:||||.||||:||.|.|||||||||.:.||||:|||||.:.|||||||||||||||||||
Frog  1030 VSFTTILDPPMNLTATEVARTSALISWQPPISPIENYILTYKSANESRKELIVDAEDTWIRLEGL 1094

Human  1100 LENTDYTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDCAQHLMNGDTLSGVYPIFLNGELSQKL 1164
            ||:|:|||.:.:.|:...||:|.|.||||||||.:|||||||::|||..||||.|::||::||.:
Frog  1095 LESTEYTVSILSVQNGERSSVTHTVFTTGGRVFSYPQDCAQHMLNGDNQSGVYYIYINGDMSQSV 1159

Human  1165 QVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNVEDEFWLGLDNIHRITSQGRYELRVD 1229
            .|||||.||.||||||||||||.||||||||||||||||:|||||||||.:|::|||||||||:|
Frog  1160 PVYCDMATDAGGWIVFQRRQNGLTDFFRKWADYRVGFGNLEDEFWLGLDTLHQVTSQGRYELRID 1224

Human  1230 MRDGQEAAFASYDRFSVEDSRNLYKLRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSY 1294
            |||||||.:|.|::|::.|:|:|||||||.:|||:||||:|||||||||:||||||||||||.||
Frog  1225 MRDGQEAVYAYYNKFNIGDARSLYKLRIGDFNGTSGDSLTYHQGRPFSTKDRDNDVAVTNCASSY 1289

Human  1295 KGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYNHRLMAGRKRQSLQ 1357
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.|   |::|||
Frog  1290 KGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYNHRTM---KKRSLQ 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNR	NP_003276.3	EGF_2	<208..230	CDD:285248	10/21 (48%)
		EGF_2	267..292	CDD:285248	19/24 (79%)
		EGF_2	299..323	CDD:285248	17/23 (74%)
		fn3	328..398	CDD:278470	46/73 (63%)
		fn3	416..496	CDD:278470	53/79 (67%)
		fn3	505..583	CDD:278470	55/77 (71%)
		FN3	595..679	CDD:238020	56/83 (67%)
		fn3	687..766	CDD:278470	57/78 (73%)
		fn3	776..855	CDD:278470	40/78 (51%)
		fn3	865..944	CDD:278470	40/78 (51%)
		fn3	954..1026	CDD:278470	41/71 (58%)
		FN3	1042..1127	CDD:238020	59/84 (70%)
		FReD	1133..1342	CDD:238040	169/208 (81%)
tnr	NP_001107287.1	EGF_alliinase	153..196	CDD:282688	25/44 (57%)
		EGF_2	198..223	CDD:285248	12/24 (50%)
		EGF_2	260..285	CDD:285248	19/24 (79%)
		EGF_2	292..316	CDD:285248	17/23 (74%)
		FN3	321..410	CDD:238020	52/88 (59%)
		fn3	413..493	CDD:278470	53/79 (67%)
		fn3	502..582	CDD:278470	57/79 (72%)
		FN3	592..676	CDD:238020	56/83 (67%)
		fn3	684..763	CDD:278470	57/78 (73%)
		fn3	773..840	CDD:278470	34/67 (51%)
		fn3	862..939	CDD:278470	40/77 (52%)
		fn3	949..1018	CDD:278470	40/68 (59%)
		FN3	1037..1122	CDD:238020	59/84 (70%)
		FReD	1129..1337	CDD:238040	169/207 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I6029
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H124416
Inparanoid	1	1.050	1799	1.000	Inparanoid score	I903
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40424
OrthoDB	1	1.010	-	-		D18592at2759
OrthoFinder	1	1.000	-	-		FOG0010583
OrthoInspector	1	1.000	-	-		oto151960
Panther	1	1.100	-	-	LDO	PTHR19143
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6496
SonicParanoid	1	1.000	-	-		X8079
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.110