DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TNFAIP6 and tld

DIOPT Version :9

Sequence 1:	NP_009046.2	Gene:	TNFAIP6 / 7130	HGNCID:	11898	Length:	277	Species:	Homo sapiens
Sequence 2:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	207	Identity:	55/207 - (26%)
Similarity:	81/207 - (39%)	Gaps:	44/207 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    43 RSG---KYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCG 104
            |||   |:.:...|    |....|..    |.......|.:.|:.      |.||.:.:.|.||
  Fly   743 RSGFVAKFVIDVDE----CSMNNGGC----QHRCRNTFGSYQCSC------RNGYTLAENGHNC- 792

Human   105 FGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKY 169
                                      ....|....|....:.:||.:|.:|..|..||||.:...
  Fly   793 --------------------------TETRCKFEITTSYGVLQSPNYPEDYPRNIYCYWHFQTVL 831

Human   170 GQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDAS 234
            |.||.|:|.||::|....|:.|||.|||...:....:|.|||...|..:|::.|.|.:...:||.
  Fly   832 GHRIQLTFHDFEVESHQECIYDYVAIYDGRSENSSTLGIYCGGREPYAVIASTNEMFMVLATDAG 896

Human   235 VTAGGFQIKYVA 246
            :...||:..:|:
  Fly   897 LQRKGFKATFVS 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNFAIP6	NP_009046.2	Link_domain_TSG_6_like	36..128	CDD:239592	16/87 (18%)
TNFAIP6	NP_009046.2	CUB	135..244	CDD:278839	38/108 (35%)
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808
		Astacin	144..339	CDD:279708
		CUB	388..474	CDD:214483
		CUB	478..586	CDD:278839
		FXa_inhibition	595..630	CDD:291342
		CUB	634..750	CDD:278839	3/6 (50%)
		FXa_inhibition	757..792	CDD:291342	9/44 (20%)
		CUB	797..906	CDD:278839	38/108 (35%)
		CUB	910..1023	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900