DRSC/TRiP Functional Genomics Resources

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Protein Alignment TNFAIP6 and Cubn

DIOPT Version :9

Sequence 1:NP_009046.2 Gene:TNFAIP6 / 7130 HGNCID:11898 Length:277 Species:Homo sapiens
Sequence 2:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster


Alignment Length:301 Identity:69/301 - (22%)
Similarity:116/301 - (38%) Gaps:68/301 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    42 ARSGKYKLTYAEAKAVCEF----EGGHLAT--YKQLEAARKIGFHVCAAGW---MAKGRVGYPIV 97
            ||:|.::|.|   :..|::    |.|.:.:  |..|..:.:|..:..:...   ::..|:.:.:.
  Fly   840 ARAGSFQLNY---RMACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLT 901

Human    98 KP--------------------------GPNCG--------FGKTGIIDYGI-----RLNRSERW 123
            ..                          ||.||        ..:|..:...:     .:.|..::
  Fly   902 NGESDDDDNDECLTTNLRINDGLNRKILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKF 966

Human   124 DAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGC 188
            :.........:||||.|......:.|...:.|.....|||.|.....:.|.|.:..|.||:...|
  Fly   967 EYRA
LATGNDKCGGVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVDC 1031

Human   189 LADYVEIYDSY-----DDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMD 248
            :.||:|||||.     |:....:.:|||:.:|:|::|....:.|||:||.|.:.|||.:.|...|
  Fly  1032 IYDYLEIYDSLGAQVNDERSKPLAKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFED 1096

Human   249 PVS-----KSSQGKNTSTTSTGNKN-------FLAGRFSHL 277
            ...     .:|.|:.||.....|.:       .|.|...||
  Fly  1097 RAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTIDHL 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TNFAIP6NP_009046.2 Link_domain_TSG_6_like 36..128 CDD:239592 18/133 (14%)
CUB 135..244 CDD:278839 40/113 (35%)
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:294042 4/8 (50%)
CUB 853..970 CDD:238001 13/116 (11%)
CUB 978..1094 CDD:238001 41/115 (36%)
CUB 1100..1211 CDD:238001 9/38 (24%)
CUB 1216..1330 CDD:238001
CUB 1446..1549 CDD:238001
CUB 1554..1667 CDD:238001
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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