Protein Alignment TRAPPC10 and SIDL

DIOPT Version :10

• Sequence 1: XP_011528016.1
• Gene: TRAPPC10 / 7109
• HGNCID: 11868
• Length: 1296
• Species: Homo sapiens
• Sequence 2: NP_650431.1
• Gene: SIDL / 41833
• FlyBaseID: FBgn0038303
• Length: 1145
• Species: Drosophila melanogaster
• Alignment Length: 1319
• Identity: 379/1319 - (28%)
• Similarity: 619/1319 - (46%)
• Gaps: 227/1319 - (17%)

Human    15 MENKPIVTCAGDQNLFTSVYPTLSQQLPREPMEWRRSYGRAPKMIHLESNFVQFKEELLP--KEG 77
            |:.|||:|.:|...||.|:...:...:|.:..||||::.|..|.:.||:...||....|.  |:|
  Fly     1 MQIKPIITYSGSCPLFRSLESQILNAIPLDTCEWRRTFQRPTKHVRLEAQAQQFNVAALEKYKQG 65

Human    78 NKALLTFPFLHIYWTECCDTEVYKATVKDDLTKWQNVLKAHSSVDWLIVIVENDAKKKNKTNILP 142
            :.::|..|.|||:.|||.|.:.||||:::.:..|...|.::...||:|::||....:|.| |.:|
  Fly    66 DWSILEHPILHIFVTECNDVDTYKATIREAIDIWLKTLTSYGVSDWMILLVETLDMRKTK-NFMP 129

Human   143 RTSIVDKIRNDFCNKQSDRCVVLSDPLKDSSRTQESWNAFLTKLRTLLLMSFTKNLGKFEDDMRT 207
            ||:::||||.||..|..|||:.:.:|.|...::.||:...:.::|.|:|.|:.:|:.|:|:.:|:
  Fly   130 RTTVLDKIRLDFGTKNDDRCISVLNPAKFEQKSTESFRCLVQRIRFLMLTSYNRNIVKYEELIRS 194

Human   208 LREKRTEPGWSFCEYFMVQEELAFVFEMLQQFEDALVQYDELDALFSQYVVNFGAGDGANWLTFF 272
            .||||...||.|.:||.:||:||.:||.|:...:||:|||||||:|||::.:.|..:...||..|
  Fly   195 KREKRNIEGWDFRQYFFMQEDLALIFEKLELPTEALIQYDELDAMFSQFITHTGLNEKQQWLNHF 259

Human   273 CQPVKSWNGLILRKPIDMEKRESIQRREATLLDLRSYLFSRQCTLLLFLQRPWEVAQRALELLHN 337
            .:|:.:::|:.|.:....|.|..|:....:||:.|:|||.||..|||......|:|:|.|..|.:
  Fly   260 RKPLDAFHGICLTRADKFEMRNKIRDEGVSLLEFRNYLFERQAYLLLTCNDIPEIAKRLLNFLFS 324

Human   338 CVQELKLLEVSVPPGALDCWVFLSCLEVLQRIEGCCDRAQIDSNIA---HTVGLWSYATEKLKSL 399
            .::|::|:::....|||.||.|:..|||||    .|::|...:.:.   |...:|:.|.:||..|
  Fly   325 TLREVELIKLECQEGALCCWEFVCALEVLQ----LCEQAMEPNELTCFQHCAPIWNLAKDKLYEL 385

Human   400 GYLCGLVSEKGPNSEDLNRTVDLLAGLGAERPETANTAQ--------SPYKK--------LKEAL 448
            |.||||:....|.||.|:..|.|.:|:|....|.....|        ||.:|        |||||
  Fly   386 GKLCGLLPGCTPTSEQLHIVVQLSSGIGDAPSEQHQFLQATPQLRDRSPNRKPKKSGAEQLKEAL 450

Human   449 SSVEAFEKHYLDLSHATIEMYTSIGRIRSAKFVGKDLAEFYMRKKAPQKAEIYLQGALKNYLAEG 513
            .|.:||:|.||:|:...|..|..:.|:|||:.||.||..||.....|.||..:....|:...||.
  Fly   451 GSNQAFQKLYLELAELAISTYKHVTRLRSARLVGLDLGNFYCALNEPHKAVGFFTDLLRELKAEN 515

Human   514 WALPITHTRKQLAECQKHLGQIENYLQTSSLLASDHHLTEEERKHFCQEIL--------DFASQP 570
            |.:..:.|..:||.|.:.:|....|.:|.|.::....|....|..:..|.|        ..::||
  Fly   516 WHMLSSQTLLELANCYRKMGDSLAYTKTCSSISCCAELETLVRTFYFDEFLKSLKTLKTTLSAQP 580

Human   571 SDSPGHKIVLPMHSFAQLRDLHFDPSNAVVHVGGVLCVEITMYSQMPVPVHVEQIVVNVHFSIEK 635
            |....:..||..|  .::.|:.......::....:| |::.:.|..|..|..|.  |.:.:.:|.
  Fly   581 SIENANYCVLEDH--FRILDIEVVNQKPIIQDDYIL-VQLKVESLYPRGVVAEN--VKLCYELEA 640

Human   636 NSYRKTAEWLTKHKTSNGIINFPPETAPFPVSQNSLP-ALEL-YEMFERSPSDNSLNTTGIIC-- 696
            :|.....|        |..:...|.|.....:.:.|. :|:| |:      .||.|::..:.|
  Fly   641 SSLELAME--------NVSLTASPSTVKAKDTSSRLKVSLQLVYK------QDNRLHSAAVACDL 691

Human   697 RNVHMLLRRQESSSSLEMPSGVALEEGAHVLRCSHVTLEPGANQITFRTQAKEPGTYTLRQLCAS 761
            ......:||..|:.....||..|  :..:.::..::.|:||.|.|..:.:|...|.:..:|||.|
  Fly   692 PKSKQPVRRTSSTKRKLSPSVQA--DFTNFVQAENIALQPGVNLIEMKAKATRVGCWQFKQLCIS 754

Human   762 VGSVWFVLPHIYPIVQYDVYSQEPQLHVEPLAEDFWAQMCRDFPLPASKQSVLQFSSDPVYWSWR 826
            :.|:.|:               ..||...|...:...:       |||  :.|:|.
  Fly   755 MSSLEFL---------------SEQLPFMPATFEISTK-------PAS--ATLEFK--------- 786

Human   827 QTPQDSLLAGIPQRVKFTVTTGHY--------TIKNGDSLQLSNAEAMLILCQAESRAVVYSNTR 883
                 :|:|||.|.:...|:.|.:        |::...:|::..|                   |
  Fly   787 -----TLIAGIVQPISLNVSGGSFIFPPDAKITLRCSKNLRIRQA-------------------R 827

Human   884 EQSSEAALR-IQSSDKVTSISLPVAPAYHVIEFELEVLSLPSAPALGGESDMLGMAEPHRKHKDK 947
            ....|||.. .||.:....:.|....::......||||           :||     |.||....
  Fly   828 NTDDEAAYNDDQSFESTLQVPLVQFKSFEERRIPLEVL-----------TDM-----PGRKVSKH 876

Human   948 QRTGRCMVTTDHKVSIDCPWSIYSTVIALTFSVPFRTTHSLLSSGTRKYVQVCVQNLSELDFQLS 1012
            .         :|.::::||||.....||:.|......|..|.:.||:|::||.::.: |....|.
  Fly   877 H---------EHHIALNCPWSRTELPIAVDFQPAMEATCRLHTCGTQKFLQVIMKGM-EAHLLLQ 931

Human  1013 DSYLVDTGDSTDLQLVPLNTQSQQP--IYSKQSVFFVWELK----WTEEPPPSLHCRFSVGFSPA 1071
            .:.:  ..|...:||:.||.:||||  ||...:|.:::|::    .||...|.:...|.:.::..
  Fly   932 HAQV--KCDVPGVQLLDLNPESQQPIEIYKSLTVTYLYEIQVEPLKTEHELPVVKVHFVIKYASL 994

Human  1072 SEEQLSISLKPYTYEFKVENFFTLYNVKAEIFPPSGMEYCRTGSLCSLEVLITRLSDLLEVDKDE 1136
            |:..:   .:.|...|.:.::.||:.::|::.|   .|.||..::|::.:.||::
  Fly   995 SQPDV---WRTYGCAFDLVDYTTLFKLQAQLEP---NELCRLRTVCNMNLKITKV---------- 1043

Human  1137 ALTESDEHFSTKLMYEVVDNSSNWAVCGKSCGVISMPVAARATHRVHMEVMPLFAGYLPLPDVRL 1201
                 .|:..|.|||||:::.:.|||||:|.||:||...  .:|.:.::||||..|:||:|.:||
  Fly  1044 -----HENPYTDLMYEVLNDQNLWAVCGRSAGVVSMKDV--DSHSISLDVMPLSTGFLPMPSIRL 1101

Human  1202 FKYLPHHSAHSSQLDADSWIENDSLSVDKHGDDQPDSSSLKSRGSVHSACSSEHKGLPMPRLQAL 1266
            .||                                 ::..||:...||            ::...
  Fly  1102 SKY---------------------------------TAGGKSKTDGHS------------KVHPF 1121

Human  1267 PAGQVFNSSSGTQVLVIPS 1285
            |.|||:||:...|:.||.|
  Fly  1122 PPGQVYNSTKSMQIHVIAS 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRAPPC10	XP_011528016.1	TRAPPC10	1106..1283	CDD:403698	47/176 (27%)
SIDL	NP_650431.1	TRAPPC10	980..1138	CDD:403698	56/225 (25%)