DRSC/TRiP Functional Genomics Resources

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Protein Alignment NR2E1 and nhr-67

DIOPT Version :10

Sequence 1:NP_001273031.1 Gene:NR2E1 / 7101 HGNCID:7973 Length:422 Species:Homo sapiens
Sequence 2:NP_502094.1 Gene:nhr-67 / 178024 WormBaseID:WBGene00003657 Length:416 Species:Caenorhabditis elegans


Alignment Length:390 Identity:119/390 - (30%)
Similarity:191/390 - (48%) Gaps:100/390 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    39 SLLESPGGRI-LDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCK---SGNQGGCPV 99
            |.:..|..|| ||:.|:||.|.||||||.:::||||:|||||||||:|.||||   |.::|.|.|
 Worm     6 SQMSVPSSRILLDVDCRVCEDHSSGKHYSIFSCDGCAGFFKRSIRRHRQYVCKNKGSPSEGQCKV 70

Human   100 DKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPA 164
            |||||||||||||:||||:.|||||||||||||.|::|:|..::      ::|::.:.|.....:
 Worm    71 DKTHRNQCRACRLRKCLEIGMNKDAVQHERGPRNSSLRRQQMMF------DHGSSPNSPEMGSES 129

Human   165 PAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARL 229
            .|.....:.:.                                           .::|..:|||:
 Worm   130 DAIILPTSSMN-------------------------------------------RDTVAGTAARI 151

Human   230 LFMSIKWAKS----VPAFSTLSLQDQLMLLEDAWRELFVLGIAQW-AIPVDANTLLAVSGMNGDN 289
            .|..:.:.::    ||.      :.|:.:.:..|..|.||...:. ||.........:||     
 Worm   152 FFALVGFCQNPLNGVPK------ERQMTMFQQNWAALLVLHATETRAITSKQIRTETISG----- 205

Human   290 TDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAAL 354
             .|::.|.:.:..:.::       :|:||..|:..||....::..|                :|:
 Worm   206 -SSEQRNAVANAFEIIE-------RLQLDNREYMMLKHFTMWRDTP----------------SAI 246

Human   355 QDEAQL-TLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYK 418
            |...|| ::.::.|.   |:|.|:   :..:.|:.:|..::|.:|.|:.:||:..:.||:.||:|
 Worm   247 QIVFQLASIQNFTHR---TEPTRY---IQCINAIAAIPTTSIIDVLFRPSIGSASMPRLIQDMFK 305

Human   419  418
             Worm   306  305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NR2E1NP_001273031.1 NR_DBD_TLX 45..136 CDD:143537 67/94 (71%)
NR_LBD_Tlx_PNR_like 191..406 CDD:132748 39/220 (18%)
nhr-67NP_502094.1 NR_DBD_like 13..107 CDD:413390 67/93 (72%)

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