back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TLR5 and Tollo

DIOPT Version :9

Sequence 1:	NP_003259.2	Gene:	TLR5 / 7100	HGNCID:	11851	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	1071	Identity:	240/1071 - (22%)
Similarity:	388/1071 - (36%)	Gaps:	323/1071 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTID 87
            |.|...|.|  |.|.        :|.:.|.||.|.:.::..:....|.:|..|.:.........|
  Fly   197 SASLSSRKA--RVCG--------STLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLAD 251

Human    88 KEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152
            : ||..|.:||::||.::::..|.|:.|.....|.|  :|....|..||..|.|..|..|..|||
  Fly   252 R-AFEGLLSLRVVDLSANRLTSLPPELFAETKQLQE--IYLRNNSINVLAPGIFGELAELLVLDL 313

Human   153 SKNQIRSLYLH-PSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSL-------- 208
            :.|::.|.::: .:|..|..|..:|.|:|:|..:..|...||  .:|....|..|.:
  Fly   314 ASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPL--ASLQILKLEDNYIDQLPGGIF 376

Human   209 ------------YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 261
                        .:|:||...:.:...:|:::..||.              |.||:....||:..
  Fly   377 ADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDF--------------NRISRMDQRSLVNC 427

Human   262 HHIMGAGFGFHNIK---------------DPDQNTFAGLARSSVRHLDLSHGFVFSLNS------ 305
            ..:.......:.::               |..:|..:.:..:|:..|:..:|...:.||
  Fly   428 SQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRR 492

Human   306 RVFETLKDLKVLNLAYNKINKIADEA-------------------------FYGLDNLQVLNL-- 343
            .||:.:..|::|||:.||:..|  ||                         |..|.||..||:
  Fly   493 GVFDRMSSLQILNLSQNKLKSI--EAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISG 555

Human   344 ---------------------------------------------SYNLLGELYSSNFYGLPKVA 363
                                                         |||||.|:.:|:.....:|.
  Fly   556 NRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVL 620

Human   364 YIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPS------------IPDIFLSGN--- 413
            |  |..|.|:.||..||.....|..:||..|.|||:.  |:            ||:.::..|
  Fly   621 Y--LNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLE--PNALRLSPIAEDREIPEFYIGHNAYE 681

Human   414 ---KLVTLPKINLTANLIHLSENRLENLDILYFLLRV----PHLQILILNQNRF----------- 460
               .|..|.|:|..:.    ::.:|.:||.::..|..    .|:.::....:.|
  Fly   682 CDCNLDWLQKVNRESR----TQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFAL 742

Human   461 ------------------SSCSGDQT-----------------PSENP-SLEQLFLGENMLQLAW 489
                              .||..||:                 ||..| ...||:|..|..:
  Fly   743 CHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFR--- 804

Human   490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEI 552
              ||....|.|...|:||:|||:.:..|....|..|..|..|.|.||:|..|:.|:...  ||:.
  Fly   805 --ELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQE 867

Human   553 LDISRNQLLAPNPDVFV---SLSVLDITH-----------------------NKFICECE----L 587
            |.:..|.:...:...|.   .|.:|.:.|                       |.:.|.||    |
  Fly   868 LYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLPSYLNELRLASNPWTCSCEFIDKL 932

Human   588 STFINWLNHTNV---------TIAGPPADIYCVYPDSFSGVSL----------------FSLSTE 627
            ..:||  .|..|         .|:|.......:||.|....||                |:.:.:
  Fly   933 RDYIN--RHEYVVDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQ 995

Human   628 -GCDEEEVLKSLKFSL----------FIVCTVTLTLFLMTILTVT-----KFRGFCFI-----CY 671
             |.:......|.|..|          .:|..:|..:|:|..:::.     :.|.:|..     .:
  Fly   996 AGGENASNATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFGVRLF 1060

Human   672 KTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVP 736
            ..||:.|.|:..:..      :||::.:||||..:|...|...|:   ..::|:.||..:|||..
  Fly  1061 YNAQKDVDKNEREKL------FDAFVSYSSKDELFVNEELAPMLE---MGEHRYKLCLHQRDFPV 1116

Human   737 GENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLM 801
            |......|..||.:||:.:.:||.:|::..||...|..|....|.|....||::|:|.:.|.:|
  Fly  1117 GGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKEL- 1180

Human   802 KHQSIRGFVQKQQYLRWPEDLQDVGWFLHKL 832
             ...:|.:::...||:|.:.|     |..||
  Fly  1181 -DPDLRLYLKTNTYLQWGDKL-----FWQKL 1205

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.