DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR5 and Tl

DIOPT Version :9

Sequence 1:NP_003259.2 Gene:TLR5 / 7100 HGNCID:11851 Length:858 Species:Homo sapiens
Sequence 2:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster


Alignment Length:945 Identity:217/945 - (22%)
Similarity:380/945 - (40%) Gaps:216/945 - (22%)


- Green bases have known domain annotations that are detailed below.


Human     4 HLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFC--NLTQVPQVLNTTER----LLLSFNYIRTVT 62
            |||.|.|                   :..:||.  .||.:|..|.|..|    |.|..| |..:.
  Fly   145 HLDRLHG-------------------LKRFRFTTRRLTHIPANLLTDMRNLSHLELRAN-IEEMP 189

Human    63 ASSFPFLEQLQLLELGS---QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFEL 124
            :..|..||.|:.:|.||   :..|..|    |..:|.|:.|:|.|::::.|....|:|...:..:
  Fly   190 SHLFDDLENLESIEFGSNKLRQMPRGI----FGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGI 250

Human   125 RLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPS--FGKLNSLKSIDFSSNQI----- 182
            .::..|:..  |....|.:|..:|.::||.|..|||   |.  |.....|..:...:|::     
  Fly   251 DIHDNGIEQ--LPHDVFAHLTNVTDINLSANLFRSL---PQGLFDHNKHLNEVRLMNNRVPLATL 310

Human   183 ------------FLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSG 235
                        .|....||:.|.|......:...|       :..|.  |..:.:...:|:...
  Fly   311 PSRLFANQPELQILRLRAELQSLPGDLFEHSTQITN-------ISLGD--NLLKTLPATLLEHQV 366

Human   236 NGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV 300
            |..::|::.|....:..|     :.||..        |:.|                |.|....:
  Fly   367 NLLSLDLSNNRLTHLPDS-----LFAHTT--------NLTD----------------LRLEDNLL 402

Human   301 FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-----------LLGELYSS 354
            ..::..:|..|.:|..|.::.|::..|...||...:.|:.|:|.:|           :|....:|
  Fly   403 TGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINS 467

Human   355 NFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI-FLSGNKLVTL 418
            .|..:..:..::|:.|.|..:.:.....:.:|:.|||..|.::::.:    .|: |||.|:|   
  Fly   468 PFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGY----EDLAFLSQNRL--- 525

Human   419 PKINLTANLI---------HLSE---NRLENLD-----------ILYF--LLRVPH----LQILI 454
             .:|:|.|.|         ||.|   |.|.::|           ||:|  |:|..|    .:...
  Fly   526 -HVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFK 589

Human   455 LNQNRFSSCSG----DQTP---------------SENPSLEQLFLGENMLQLAWETELCWDVFEG 500
            |..:|. .||.    :.||               |::|...:...|.|.....::..|..:...|
  Fly   590 LRTDRL-VCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSG 653

Human   501 -LSH------------LQVLYLNHNYLNSLP----PGVFSHLTALRGLSLNSNRLTVLSHNDLPA 548
             |:|            |..|:|.:|.|..||    || :..:|:|.   |..|.||.:..:.||.
  Fly   654 NLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPG-YESVTSLH---LAGNNLTSIDVDQLPT 714

Human   549 NLEILDISRNQLLAPNPDV--FVSLSV----LDITHNKFICECELSTFINWLNHTNVTIAGPPAD 607
            ||..||||.|.|...|..|  |::.::    :.::.|.::|:|.....: .....|....|...:
  Fly   715 NLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLL-LFTQDNFERIGDRNE 778

Human   608 IYCVYPDSFSGVSLFSLSTEG-CDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFI-C 670
            :.||  ::.....:..|||.. |..|   |.:..:|.:|..:|..|...|.....||:....| .
  Fly   779 MMCV--NAEMPTRMVELSTNDICPAE---KGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWL 838

Human   671 YKTAQRLVFKDHPQGTEPDM---YKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEER 732
            |.....|.|.     ||.|:   .|:||::.:|.||.:::::.|:..|:   ....:|.||..||
  Fly   839 YAHNLLLWFV-----TEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLE---HGPQKFQLCVHER 895

Human   733 DFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQ 797
            |::.|.:...||..::.:||:.:.::|::|::..|....|..|....|::..|.:|:::...:..
  Fly   896 DWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGD 960

Human   798 YQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKL 832
            .:.: .:.::.:::...||:|.:.     ||..||
  Fly   961 VEKL-DEELKAYLKMNTYLKWGDP-----WFWDKL 989

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TLR5NP_003259.2 LRR 1. /evidence=ECO:0000269|PubMed:22173220 45..68 8/26 (31%)
leucine-rich repeat 48..83 CDD:275378 12/41 (29%)
LRR 2. /evidence=ECO:0000269|PubMed:22173220 71..93 7/24 (29%)
PLN00113 90..>581 CDD:331614 131/592 (22%)
LRR 3. /evidence=ECO:0000269|PubMed:22173220 95..117 7/21 (33%)
leucine-rich repeat 97..120 CDD:275380 7/22 (32%)
LRR 4. /evidence=ECO:0000269|PubMed:22173220 120..143 3/22 (14%)
leucine-rich repeat 121..146 CDD:275380 4/24 (17%)
LRR 5. /evidence=ECO:0000269|PubMed:22173220 146..166 8/21 (38%)
leucine-rich repeat 147..171 CDD:275380 9/25 (36%)
LRR 6. /evidence=ECO:0000269|PubMed:22173220 171..192 5/37 (14%)
leucine-rich repeat 172..205 CDD:275380 7/49 (14%)
LRR 7. /evidence=ECO:0000269|PubMed:22173220 197..211 1/13 (8%)
LRR 8. /evidence=ECO:0000269|PubMed:22173220 214..229 2/14 (14%)