back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TLR5 and Toll-7

DIOPT Version :9

Sequence 1:	NP_003259.2	Gene:	TLR5 / 7100	HGNCID:	11851	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	208/927 - (22%)
Similarity:	350/927 - (37%)	Gaps:	255/927 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    44 VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIY 108
            |||.....|...:| ||     |..|..||:|.|.:.... .|:..||..|.||..|:|..::::
  Fly   374 VLNLAHNALTRIDY-RT-----FKELYFLQILNLRNNSIG-HIEDNAFLPLYNLHTLNLAENRLH 431

Human   109 FLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ-------------IRSL 160
            .|....|.||:.|.:|.|....:|  |::...|:|...|..||||.||             :|:|
  Fly   432 TLDDKLFNGLYVLSKLTLNNNLIS--VVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTL 494

Human   161 YL---------HPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYS--RVSV 214
            .|         :.||..|:.|..:....|||..:.....:.|  ..||..:||.|.:.|  |.|.
  Fly   495 DLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDL--PRLSVLNLAKNRIQSIERGSF 557

Human   215 DWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQ 279
            |        :|..||.:.:..| :..||.|.|:..:  |..:..:..:|::...:.|
  Fly   558 D--------KNFELEAIRLDRN-FLADINGVFATLV--SLLWLNLSENHLVWFDYAF-------- 603

Human   280 NTFAGLARSSVRHLDLSHGFVFSLNS--RVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLN 342
                  ..|:::.||:...::.:|.:  ::.|.:: :|.|:.::|:|.:|...:.  .:.:::|.
  Fly   604 ------IPSNLKWLDIHGNYIEALGNYYKLQEEIR-VKTLDASHNRITEIGPMSI--PNTIELLF 659

Human   343 LSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD 407
            ::.||:|.:..:.|.....:|.:||..|.           |.|||...||   :..:.....:|:
  Fly   660 INNNLIGNVQPNAFVDKANLARVDLYANQ-----------LSKLQLQQLR---VAPVVAPKPLPE 710

Human   408 IFLSGN------KLVTLPKINLTANLIHLSENRLENLDILY------------------FLLRVP 448
            .:|.||      .:..|.:||......|.....:.|::.:.                  ||.|..
  Fly   711 FYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYE 775

Human   449 ----------------------------HLQILILNQNRFSSCSGDQT-------PSEN------ 472
                                        |.||...|   ...|.|.||       |.::
  Fly   776 SHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTN---VVDCGGQQTTELPRRVPMDSSVVYLD 837

Human   473 ----PSLE-QLFLGENMLQLAW-----ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
                |.|: ..|:|...|:..:     ...:....|..|:.||:|:|..|.|.:|....|..|:|
  Fly   838 GNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSA 902

Human   528 LRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFVSLSV--LDITH---------- 578
            ||.|.|.:|:||.:.:..|.  |.||::.|..|:|        |:|.:  :..||
  Fly   903 LRELYLQNNQLTTIENATLAPLAALELIRIDGNRL--------VTLPIWQMHATHFGTRLKSISL 959

Human   579 --NKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF--SLSTEGCDEEEVLKSLK 639
              |::.|.|:....:......|..|.....||||:...|.:|.:..  |.|..|..|:   :.|.
  Fly   960 GRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEK---RELD 1021

Human   640 FS------------------------LFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFK 680
            |:                        :.::......|||:.::.:.       ..::.:.|:...
  Fly  1022 FNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMV-------FAFRESLRIWLF 1079

Human   681 DH-------PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGE 738
            .|       |:..|.:.. |||.|..|:||..:|...|...|:|   .:....:|.:.||.....
  Fly  1080 AHYGVRVFGPRCEESEKL-YDAVLLHSAKDSEFVCQHLAAQLET---GRPPLRVCLQHRDLAHDA 1140

Human   739 NRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKH 803
            ... .:.:|...||::|.|::|:||:..|         .||  :|..::               |
  Fly  1141 THY-QLLEATRVSRRVVILLTRNFLQTEW---------ARC--ELRRSV---------------H 1178

Human   804 QSIRGFVQKQQYLRWPE 820
            .::||..||...:..||
  Fly  1179 DALRGRPQKLVIIEEPE 1195

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.