DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPING1 and Spn88Eb

DIOPT Version :9

Sequence 1:	NP_000053.2	Gene:	SERPING1 / 710	HGNCID:	1228	Length:	500	Species:	Homo sapiens
Sequence 2:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	98/402 - (24%)
Similarity:	177/402 - (44%)	Gaps:	69/402 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   148 DFSLKLYHAFSAMKKVET-----NMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVH 207
            ||||.|      ||::..     |:.|||||..:.|......:.|.|:..|...|:...... ..
  Fly    40 DFSLAL------MKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALN-KQ 97

Human   208 QALKGFT-------------TKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRV-LSNNSDAN 258
            |.|..:|             ...::|.::||....:.:.:.|   :..||.::..: ..|:.:..
  Fly    98 QVLVSYTLAQRQDEFRWRQSPMELSSANRIFVDRTINVSNKF---NTLLYGATKELDFKNDPETG 159

Human   259 LELINTWVAKNTNNKISRLLDS--LPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIK 321
            |:.||.|:|..|:|:|..:|.|  :...|.|||.||.|:..:|.:.|..::|.::||.......:
  Fly   160 LKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQE 224

Human   322 VPMMNSKKYPVAHFIDQTLKAKVGQL----------------QLSHNLSLVILVPQNLKHRLEDM 370
            :..|..|.......||:.|::::.:|                :...::|::|::|.:.|..|..:
  Fly   225 MVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLNRV 289

Human   371 EQALSPSVFK-----AIMEKLEMS--KFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLC 428
            ...|:....|     |:.:|:|:|  |||    ...|:::|....::.:...     |:.:....
  Fly   290 ISRLNADSVKKWFERALPQKIELSLPKFQ----FEQRLELTPILSLMGVNTM-----FTRNATFG 345

Human   429 GLTEDP-DLQVSAMQHQTVLELTETGVEAAAASAISVARTL-----LVFEVQQPFLFVLWDQQHK 487
            .||.|| .|.:...||...:::.|.|..||||:.:.|:|:.     ..|....||:|:::|::..
  Fly   346 DLTADPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFVFLIYDEKVD 410

Human   488 FPVFMGRVYDPR 499
            ..:|.|...|||
  Fly   411 TILFAGVYSDPR 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPING1	NP_000053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..118
		7 X 4 AA tandem repeats of [QE]-P-T-[TQ]	85..119
		C1_inh	145..495	CDD:239005	95/396 (24%)
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	95/396 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010