DRSC/TRiP Functional Genomics Resources

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Protein Alignment TLR4 and Tl

DIOPT Version :9

Sequence 1:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens
Sequence 2:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster


Alignment Length:906 Identity:221/906 - (24%)
Similarity:352/906 - (38%) Gaps:262/906 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    30 VEVVP--------NITYQCMELNFYK-IPDNLPFSTKNLD---LSFN--PLRHLGSYSFFSFPEL 80
            :|.:|        |:|...:..|.:: :|..|....|:|:   |..|  ||..|.|..|.:.|||
  Fly   257 IEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPEL 321

Human    81 QVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFP 145
            |:|.| |.|:|::....::..:.::.:.|..|.:::|.........:|..|......|..|.:..
  Fly   322 QILRL-RAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSL 385

Human   146 IGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSI------YCTDLRVLH----- 199
            ..|...|.:|.:..||:.... .:.||||.||..|.:|.|::::|      ....||.||     
  Fly   386 FAHTTNLTDLRLEDNLLTGIS-GDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHND 449

Human   200 ---QMPLLNLSLDLSLN-PMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVL 260
               |.|||::.|...:| |..::.       .|..|.||||    :::              .|.
  Fly   450 IDLQQPLLDIMLQTQINSPFGYMH-------GLLTLNLRNN----SII--------------FVY 489

Human   261 GEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSL---------- 315
            .:::|               ..|.:.|..|:|               .|:||...          
  Fly   490 NDWKN---------------TMLQLRELDLSY---------------NNISSLGYEDLAFLSQNR 524

Human   316 --VSVTIERVKDFS----------YNFGWQHLEL------VNCKFGQFPTL-------------K 349
              |::|..:::..:          ||....|::|      .:|....|..|             |
  Fly   525 LHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFK 589

Human   350 LKSLKRLTFTSN-KGGNAFSEVD----LPSLEFLDLSRNGLSFKGC-CSQSDFGTTSLKYLDLSF 408
            |::.:.:....| ..|....:::    :..|:|.|..|.....:|| |....:.    |.|.::.
  Fly   590 LRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYD----KALVINC 650

Human   409 NGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSL 473
            :     |.|...:.:|.:|   |.|::.|.     |.|.|...|.:...:|        .|..|:
  Fly   651 H-----SGNLTHVPRLPNL---HKNMQLME-----LHLENNTLLRLPSANT--------PGYESV 694

Human   474 EVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
            ..|.:|||               |||.:|:.|.      ||           |::|         
  Fly   695 TSLHLAGN---------------NLTSIDVDQL------PT-----------NLTH--------- 718

Human   539 PYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLN---------LTQNDFACTCEHQSFLQWI 594
                      ||.|.||:     |.|.  .:.|.|||         |:.|.:.|.|..:..|.:.
  Fly   719 ----------LDISWNHL-----QMLN--ATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFT 766

Human   595 KDQRQLLVEVERMECATPSDKQGMPVLSLNITCQMNKTI-IGVSV---LSVLVVSVVAVLVYKF- 654
            :|..:.:.:...|.|........|..||.|..|...|.: |.::|   |:.|:....|.|.||| 
  Fly   767 QDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQ 831

Human   655 -------YFHLMLLAGCIKYGRGENI-----YDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCL 707
                   |.|.:||    .:...|::     :|||:.||.:|:.::.:.||..||.|...||||:
  Fly   832 TEIKIWLYAHNLLL----WFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCV 892

Human   708 HYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIV-- 770
            |.||::.|..|..||: .....||:.|:|:||:||:|.|...|:..|........|:.||.|:  
  Fly   893 HERDWLVGGHIPENIM-RSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYS 956

Human   771 -LQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTG 830
             :..|||  |.::::.|  |..||||:|.|.     .||.:||.||...:   |.|.:|.|
  Fly   957 DIGDVEK--LDEELKAY--LKMNTYLKWGDP-----WFWDKLRFALPHRR---PVGNIGNG 1005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR4NP_612564.1 LRR_RI 55..>195 CDD:238064 40/150 (27%)
LRR 1 55..76 9/25 (36%)
leucine-rich repeat 56..79 CDD:275378 9/27 (33%)
LRR_8 57..114 CDD:290566 20/61 (33%)
LRR 2 79..100 8/20 (40%)
leucine-rich repeat 80..103 CDD:275378 7/22 (32%)
LRR_8 102..187 CDD:290566 21/84 (25%)
LRR 3 103..124 3/20 (15%)
leucine-rich repeat 104..127 CDD:275378 3/22 (14%)
LRR 4 127..148 4/20 (20%)
leucine-rich repeat 128..176 CDD:275378 13/47 (28%)
leucine-rich repeat 130..151 CDD:275380 4/20 (20%)
LRR 5 151..172 4/20 (20%)
LRR_RI 152..456 CDD:238064 73/365 (20%)
LRR 6 176..199 8/28 (29%)
leucine-rich repeat 177..190 CDD:275378 4/12 (33%)
leucine-rich repeat 195..224 CDD:275380 11/37 (30%)
LRR 7 205..225 3/20 (15%)
LRR 8 227..247 6/19 (32%)
LRR 9 331..351 6/38 (16%)
LRR 10 352..373 2/25 (8%)
leucine-rich repeat 353..374 CDD:275380 2/25 (8%)
LRR_RI <372..581 CDD:238064 49/218 (22%)
LRR 11 374..394 7/20 (35%)
LRR_8 399..458 CDD:290566 13/58 (22%)
LRR 12 400..422 4/21 (19%)
leucine-rich repeat 401..423 CDD:275380 4/21 (19%)
LRR 13 423..444 5/20 (25%)
leucine-rich repeat 424..448 CDD:275380 7/23 (30%)
LRR_8 447..508 CDD:290566 14/60 (23%)
LRR 14 448..456 2/7 (29%)
leucine-rich repeat 449..472 CDD:275380 3/22 (14%)
LRR 15 472..495 5/22 (23%)
leucine-rich repeat 473..497 CDD:275380 4/23 (17%)
LRR 16 497..518 7/20 (35%)
leucine-rich repeat 498..521 CDD:275380 6/22 (27%)
LRR_8 520..581 CDD:290566 15/69 (22%)
LRR 17 521..542 2/20 (10%)
LRR 18 545..565 6/19 (32%)
leucine-rich repeat 546..570 CDD:275380 7/23 (30%)
LRRCT 579..625 CDD:214507 10/45 (22%)
TIR 674..815 CDD:214587 54/143 (38%)
TlNP_001262995.1 LRR_8 174..233 CDD:290566
leucine-rich repeat 176..198 CDD:275380
leucine-rich repeat 199..222 CDD:275380
LRR_RI 216..542 CDD:238064 75/341 (22%)
LRR_8 221..281 CDD:290566 5/23 (22%)
leucine-rich repeat 223..270 CDD:275380 2/12 (17%)
leucine-rich repeat 271..294 CDD:275380 4/22 (18%)
leucine-rich repeat 295..320 CDD:275380 8/24 (33%)
leucine-rich repeat 321..343 CDD:275380 7/22 (32%)
LRR_8 342..402 CDD:290566 11/59 (19%)
leucine-rich repeat 344..367 CDD:275380 3/22 (14%)
leucine-rich repeat 368..391 CDD:275380 5/22 (23%)
LRR_8 390..450 CDD:290566 18/60 (30%)
leucine-rich repeat 392..415 CDD:275380 8/23 (35%)
leucine-rich repeat 416..439 CDD:275380 5/22 (23%)
leucine-rich repeat 440..474 CDD:275380 11/40 (28%)
leucine-rich repeat 475..498 CDD:275380 8/55 (15%)
LRR_8 477..534 CDD:290566 16/104 (15%)
leucine-rich repeat 499..520 CDD:275380 6/35 (17%)
leucine-rich repeat 523..552 CDD:275380 4/28 (14%)
LRRCT 561..619 CDD:214507 7/57 (12%)
LRRNT 631..667 CDD:214470 10/47 (21%)
leucine-rich repeat 664..693 CDD:275380 10/44 (23%)
LRR_8 669..726 CDD:290566 25/120 (21%)
leucine-rich repeat 694..715 CDD:275380 11/52 (21%)
leucine-rich repeat 716..737 CDD:275380 9/46 (20%)
LRRCT 751..800 CDD:214507 11/48 (23%)
TIR 858..996 CDD:214587 56/147 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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