DRSC/TRiP Functional Genomics Resources

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Protein Alignment TLR4 and Tehao

DIOPT Version :9

Sequence 1:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens
Sequence 2:NP_001285901.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster


Alignment Length:803 Identity:202/803 - (25%)
Similarity:314/803 - (39%) Gaps:235/803 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    68 HLGS------YSFFS-FPELQVLDLSRCEIQTIEDGAYQSLS--HLSTLILT--GNPIQSLALGA 121
            |.||      :.||| .||||         ::|..| :.:|.  |||..:.|  ||.:.::.   
  Fly   155 HFGSVPGLKKFKFFSHVPELQ---------ESIFHG-FDTLRDLHLSVNVTTLPGNMLSTVN--- 206

Human   122 FSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFK------LPEYFSNLTNLEHL 180
                .:|:.|......:.|..|..:..|:.|:.|::|  ||..|.      .|.:|.::||||.:
  Fly   207 ----GTLKTLTIESPGIVSFGNPLLRELQQLRNLSLA--LIHPFHERDKQLQPHFFGSMTNLEEV 265

Human   181 DLSS-------------NKIQSIYCTDLRVLHQMP------LLNL-SLDLSLNPMNFIQPGAFKE 225
            .|:|             ||:|.|.......|.::|      .:|| :||||.|.:..:....|| 
  Fly   266 RLASATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFK- 329

Human   226 IRLHKLTL----RNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIE 286
             .|..|||    :|..  .|:..|....|..|.|.||      |:.:|.....|..:.:.:|.  
  Fly   330 -GLGNLTLLDLSKNRL--TNLSSTIFAPLTSLNVLRL------NKNSLTAMSPSVFQDVVSLN-- 383

Human   287 EFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLK 351
                     |::.:...|...|.:.::..|..|.:....:. :..||      |           
  Fly   384 ---------YIEMVNTQFYGATLLMNYEAVVCTNDEACQYK-SAEWQ------C----------- 421

Human   352 SLKRLTFTSNKGGNAFSEVDLPSLEFL-DLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMS 415
            ..:.:.:.....|:...:....|||.| ||.|               ||.|       :.|:.:.
  Fly   422 DPRCICWVQRSVGSLIVDCRGTSLEELPDLPR---------------TTLL-------STVLKVG 464

Human   416 SNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
            :|.|            ::|..:||.|.:.::..|...|              |.|:||      |
  Fly   465 NNSL------------TSLPTVSEHSGYANVSGLFLSD--------------NNLTSL------G 497

Human   481 NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNS 545
            :..|   |||      |||.||:...|::.||                       |.|    |..
  Fly   498 SGDQ---LPD------NLTHLDVRGNQIQSLS-----------------------DEF----LLF 526

Human   546 LQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECA 610
            ||    ..|:.||               |:|:.|...|.||..|.|.:::...|.:.::..:.| 
  Fly   527 LQ----EPNNTMT---------------LSLSGNPITCGCESLSLLFFVRTNPQRVRDIADIVC- 571

Human   611 TPSDK--QGM------PVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKY 667
            |...|  |.|      |...|.|:|.:...:|.:.:|:|..:.....|....|.:.:    |:.:
  Fly   572 TKQKKSFQQMEAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNL----CLWW 632

Human   668 GRGENI-----YDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGF 727
            ...|.:     ||||:.||.:||:.: ::|:..||.|..||:||||.||::.|..|...|:.. .
  Fly   633 VSEEELDKDKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRT-V 695

Human   728 HKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRN 792
            ..|::||:|:|||||.|.|...|:.||........|..||.|:.:::|. :.....||...|..|
  Fly   696 DDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEH-MNGIDSELRAYLKLN 759

Human   793 TYLEWEDSVLGRHIFWRRLRKAL 815
            |||:|.|.     :||.:|..|:
  Fly   760 TYLKWGDP-----LFWSKLYYAM 777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR4NP_612564.1 LRR_RI 55..>195 CDD:238064 42/156 (27%)
LRR 1 55..76 4/13 (31%)
leucine-rich repeat 56..79 CDD:275378 6/17 (35%)
LRR_8 57..114 CDD:290566 19/56 (34%)
LRR 2 79..100 5/20 (25%)
leucine-rich repeat 80..103 CDD:275378 5/24 (21%)
LRR_8 102..187 CDD:290566 26/107 (24%)
LRR 3 103..124 6/22 (27%)
leucine-rich repeat 104..127 CDD:275378 5/24 (21%)
LRR 4 127..148 4/20 (20%)
leucine-rich repeat 128..176 CDD:275378 13/53 (25%)
leucine-rich repeat 130..151 CDD:275380 4/20 (20%)
LRR 5 151..172 7/26 (27%)
LRR_RI 152..456 CDD:238064 73/334 (22%)
LRR 6 176..199 9/35 (26%)
leucine-rich repeat 177..190 CDD:275378 7/25 (28%)
leucine-rich repeat 195..224 CDD:275380 9/35 (26%)
LRR 7 205..225 8/20 (40%)
LRR 8 227..247 7/23 (30%)
LRR 9 331..351 3/19 (16%)
LRR 10 352..373 1/20 (5%)
leucine-rich repeat 353..374 CDD:275380 1/20 (5%)
LRR_RI <372..581 CDD:238064 47/209 (22%)
LRR 11 374..394 7/20 (35%)
LRR_8 399..458 CDD:290566 11/58 (19%)
LRR 12 400..422 4/21 (19%)
leucine-rich repeat 401..423 CDD:275380 4/21 (19%)
LRR 13 423..444 4/20 (20%)
leucine-rich repeat 424..448 CDD:275380 4/23 (17%)
LRR_8 447..508 CDD:290566 16/60 (27%)
LRR 14 448..456 2/7 (29%)
leucine-rich repeat 449..472 CDD:275380 4/22 (18%)
LRR 15 472..495 7/22 (32%)
leucine-rich repeat 473..497 CDD:275380 6/23 (26%)
LRR 16 497..518 8/20 (40%)
leucine-rich repeat 498..521 CDD:275380 7/22 (32%)
LRR_8 520..581 CDD:290566 11/60 (18%)
LRR 17 521..542 2/20 (10%)
LRR 18 545..565 5/19 (26%)
leucine-rich repeat 546..570 CDD:275380 5/23 (22%)
LRRCT 579..625 CDD:214507 14/53 (26%)
TIR 674..815 CDD:214587 54/140 (39%)
TehaoNP_001285901.1 leucine-rich repeat 185..207 CDD:275380 7/28 (25%)
leucine-rich repeat 209..232 CDD:275380 5/22 (23%)
leucine-rich repeat 233..261 CDD:275380 8/29 (28%)
LRR_RI <261..370 CDD:238064 34/118 (29%)
leucine-rich repeat 262..284 CDD:275380 4/21 (19%)
leucine-rich repeat 285..309 CDD:275380 4/23 (17%)
LRR_8 309..368 CDD:290566 22/68 (32%)
leucine-rich repeat 310..333 CDD:275380 9/24 (38%)
leucine-rich repeat 334..357 CDD:275380 7/24 (29%)
leucine-rich repeat 358..381 CDD:275380 7/28 (25%)
leucine-rich repeat 445..482 CDD:275380 16/70 (23%)
LRR_8 459..516 CDD:290566 23/97 (24%)
leucine-rich repeat 483..505 CDD:275380 11/50 (22%)
LRR_4 486..521 CDD:289563 19/86 (22%)
TIR 643..779 CDD:214587 55/143 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_116606
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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