Protein Alignment TLR3 and cDIP

DIOPT Version :10

• Sequence 1: NP_003256.1
• Gene: TLR3 / 7098
• HGNCID: 11849
• Length: 904
• Species: Homo sapiens
• Sequence 2: NP_650951.1
• Gene: cDIP / 42512
• FlyBaseID: FBgn0038865
• Length: 554
• Species: Drosophila melanogaster
• Alignment Length: 652
• Identity: 133/652 - (20%)
• Similarity: 220/652 - (33%)
• Gaps: 215/652 - (32%)

Human    19 MLCASSTTKCTVSHEVADCSHLKLT----QVPDDLPTNITVL---------NLTHNQLRRLPAAN 70
            :|.:|....|....:|..|...:..    :...||||.:.:.         :..|::........
  Fly    40 VLVSSLEGHCQTEGKVTSCRGFEFAGEDEKATFDLPTEVRIAEDGTTYEVGDEEHSRTLIFENCT 104

Human    71 FTRYSQLTSLDVGFNT--ISKLEPELCQ-----------KLPMLKVLNLQHNELSQLSDKTFAFC 122
            ||.:....     |.|  :|:|:...|.           ....|.:|.|..|.:..|..|||...
  Fly   105 FTNFPLRL-----FYTLEVSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGA 164

Human   123 TNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALK 187
            .||..:.|..|.:.|::...|.....|..|||:.|.|.:........|::|:.:.|:.|::..::
  Fly   165 GNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIE 229

Human   188 SEELDIFA-NSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLC-LELANTSI 250
            |   |:|| |..|..:.:.:|:::|.....|.:.||...:...::...|.|...|. :...|.:.
  Fly   230 S---DLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNNPELVVLLLNINATNLTA 291

Human   251 RNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFS 315
            ||.||....|            :.::|.:|||.|.:.             |.:|.....::||.
  Fly   292 RNCSLDRVNL------------YGSVTNVDLSDNRVR-------------ELYFPASEALEHLV- 330

Human   316 HSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLIN 380
                         |:.:...|..||:.:|:           |.||::.||.             |
  Fly   331 -------------LRNNSLVQLASLSRVPR-----------LRHLDVADNP-------------N 358

Human   381 LKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQ 445
            |..|.     ...||                                   .|||:  |.|...||
  Fly   359 LGQLP-----DGWRT-----------------------------------PHLEM--LVLRNTGQ 381

Human   446 -ELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLT 509
             ||..:..:|::|:.::.:|.|.                        |..:|  ||.|..|..||
  Fly   382 MELPLEALQGMQNLQKLDISGNN------------------------LTEID--PSAFPTLTQLT 420

Human   510 ILDLSNNN-----IANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHIL-- 567
            ...:..||     :.||.|.::..           |.:|....:.:|..|..:..|::.::.|
  Fly   421 HFYIHGNNWNCFSLRNIMDVLIRA-----------NGIAYTVDNYDPDFPGEYFHGIACMYRLPE 474

Human   568 --NLESNGFDEI--------------PVEVFKDLFELKII--------DLGLNNLNTLPASVFNN 608
              .::|:...||              |.||.|...|||.:        ||..:.|..|     |.
  Fly   475 KEGVDSSSSSEISASVESSPITSSSDPSEVDKLRDELKAVVQHFDSKFDLIFSKLAQL-----NE 534

Human   609 QV 610
            |:
  Fly   535 QI 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLR3	NP_003256.1	leucine-rich repeat	33..52	CDD:275380	5/22 (23%)
		LRR	<36..309	CDD:443914	64/300 (21%)
		LRR 1	52..73		2/29 (7%)
		leucine-rich repeat	53..76	CDD:275380	3/31 (10%)
		LRR 2	76..97		5/33 (15%)
		leucine-rich repeat	77..100	CDD:275380	5/35 (14%)
		LRR 3	100..121		8/20 (40%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		LRR 4	124..145		6/20 (30%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		LRR 5	148..168		6/19 (32%)
		leucine-rich repeat	149..198	CDD:275380	15/49 (31%)
		LRR 6	172..193		4/20 (20%)
		LRR 7	198..219		4/20 (20%)
		leucine-rich repeat	199..249	CDD:275380	10/50 (20%)
		LRR 8	222..244		4/22 (18%)
		LRR 9	249..270		5/20 (25%)
		leucine-rich repeat	250..275	CDD:275380	5/24 (21%)
		LRR 10	275..296		5/20 (25%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		LRR	284..>630	CDD:443914	68/359 (19%)
		LRR 11	299..320		4/20 (20%)
		leucine-rich repeat	300..321	CDD:275380	4/20 (20%)
		LRR 12	323..344		4/20 (20%)
		LRR 13	356..377		5/20 (25%)
		leucine-rich repeat	357..380	CDD:275380	5/22 (23%)
		LRR 14	380..400		5/19 (26%)
		leucine-rich repeat	381..406	CDD:275380	4/24 (17%)
		LRR 15	408..429		0/20 (0%)
		leucine-rich repeat	409..432	CDD:275380	0/22 (0%)
		LRR 16	432..454		9/22 (41%)
		leucine-rich repeat	433..457	CDD:275380	9/24 (38%)
		leucine-rich repeat	458..481	CDD:275380	2/22 (9%)
		LRR 17	465..486		1/20 (5%)
		leucine-rich repeat	482..507	CDD:275380	6/24 (25%)
		LRR 18	507..528		7/25 (28%)
		leucine-rich repeat	508..531	CDD:275380	7/27 (26%)
		LRR 19	531..552		2/20 (10%)
		leucine-rich repeat	532..563	CDD:275380	5/30 (17%)
		LRR 20	563..584		7/38 (18%)
		leucine-rich repeat	564..585	CDD:275380	8/38 (21%)
		LRR 21	587..608		7/28 (25%)
		leucine-rich repeat	588..611	CDD:275380	8/31 (26%)
		LRR 22	611..632		133/652 (20%)
		leucine-rich repeat	612..630	CDD:275380
		leucine-rich repeat	637..659	CDD:275380
		LRRCT	645..697	CDD:214507
		Tlr3_TMD	698..730	CDD:465595
		TIR	755..900	CDD:214587
cDIP	NP_650951.1	LRR	107..>410	CDD:443914	88/441 (20%)
		leucine-rich repeat	118..142	CDD:275380	3/23 (13%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		leucine-rich repeat	167..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..238	CDD:275380	8/25 (32%)
		leucine-rich repeat	239..265	CDD:275380	6/25 (24%)
		leucine-rich repeat	266..325	CDD:275380	16/83 (19%)
		leucine-rich repeat	326..347	CDD:275380	6/34 (18%)
		leucine-rich repeat	348..394	CDD:275380	20/100 (20%)
		leucine-rich repeat	395..418	CDD:275380	8/48 (17%)