DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and Toll-9

DIOPT Version :10

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_649214.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster


Alignment Length:883 Identity:208/883 - (23%)
Similarity:336/883 - (38%) Gaps:221/883 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   145 KQKNLITLDLSHNGLS-------STKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKL 202
            |..:.:.|||||..|.       ..||..:|.:...:....:.|.:.|.....| .....|||.|
  Fly    97 KYAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTL-YSMRESLKLL 160

Human   203 ELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPS-----------------LTEKLCLELANTSI 250
            .|..|...|..|.     ...|..|:|..:|..|                 |.::.|....|   
  Fly   161 SLRGNNFAELIPD-----AEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFN--- 217

Human   251 RNLSLSNSQLSTTSNTTFL---------------GLKWT------NLTMLDLSYNNLNVVGNDSF 294
            .|.::..|..:..:.|.|:               .:.|.      .|..||:|..::..|..::|
  Fly   218 NNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAF 282

Human   295 AWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEH 359
            ..:..|...|:..|.|..:...:.:.:..|:||:|  |||            :..::.:...|..
  Fly   283 RNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDL--SFT------------NFLTYSYQLQLPT 333

Human   360 LNMEDNDIPGIK--SNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAH--SPLHILNLTKNKIS 420
            |.|..:.|.|:|  .|:|..|..|.||.||:|     .:|..:.|:.||  ..|..|:|....|.
  Fly   334 LEMALSLIYGLKIQQNVFKYLPELIYLDLSHS-----KMTRNSAVAFAHLGDKLKFLSLCYTAIP 393

Human   421 KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSF-ALVPSLQR 484
            .:.|..|. ...||.|||..|.                   |||||    :..::| .:..:|:.
  Fly   394 MVSSTIFK-NTVLEGLDLSGNP-------------------YLSYN----IIDDAFDGIANTLKY 434

Human   485 LMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWK-- 547
            |...|..:|:::.|.|    |:||.:|.|:.|||..:...|.:.||.||||||..|::...::  
  Fly   435 LYFERSNIKDLEWSKS----LKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSA 495

Human   548 -HANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNL-------NTLPAS 604
             |.|           |.|.:|||.||..:.:..|:.||...|..:.||.|:.       ..:..:
  Fly   496 FHNN-----------SALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVA 549

Human   605 VFNNQ---VSLKSLNLQKNLITSVEKKVFGPAFRNLTE---LDMRFNPFDCTCESIAW---FVNW 660
            ..||:   .|.:.||..:|.:        |....:|.|   :|.:.           |   ::.|
  Fly   550 AANNKDADCSYRLLNYSQNAV--------GEEVISLAESLIIDRKL-----------WQSRYIPW 595

Human   661 INETHTNIPEL------------SSHYL---CNTPPHYH----------GFPVRLFDTS------ 694
            :..:::||.|.            |..|:   |:....||          .|.:..::.|      
  Fly   596 LQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFN 660

Human   695 ---------------SCKDSAPFELFFMINTSI-----LLIFIFIVLLIHFEGWRISFYW----- 734
                           |..|.|. ||..:.||.|     |:....:..:|:.:.|.|.:|:     
  Fly   661 NTDQLQVDELNCQIRSMSDLAE-ELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKS 724

Human   735 -----NVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFE 794
                 :.|...|..|..|.::.....|..:|.:...|:.||........:|...:..||.||||:
  Fly   725 AALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDVSICLHERDFQ 789

Human   795 AGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYK 859
            .||..|:.|::.:.||..::.:|:...|....| :|:::.|..:..|.:.:.:||||||:||..|
  Fly   790 IGVTILDNIISCMDRSYSLMLIISSKFLLSHWC-QFEMYLAQHRIFEVSKEHLILVFLEDIPRRK 853

Human   860 LNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVAL 897
            ....|   :.:......:.||..||....|..:|:.:|
  Fly   854 RPKTL---QYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 leucine-rich repeat 33..52 CDD:275380
LRR <36..309 CDD:443914 42/208 (20%)
LRR 1 52..73
leucine-rich repeat 53..76 CDD:275380
LRR 2 76..97
leucine-rich repeat 77..100 CDD:275380
LRR 3 100..121
leucine-rich repeat 101..124 CDD:275380
LRR 4 124..145 208/883 (24%)
leucine-rich repeat 125..148 CDD:275380 1/2 (50%)
LRR 5 148..168 8/26 (31%)
leucine-rich repeat 149..198 CDD:275380 12/55 (22%)
LRR 6 172..193 3/20 (15%)
LRR 7 198..219 8/20 (40%)
leucine-rich repeat 199..249 CDD:275380 15/66 (23%)
LRR 8 222..244 7/38 (18%)
LRR 9 249..270 4/35 (11%)
leucine-rich repeat 250..275 CDD:275380 5/45 (11%)
LRR 10 275..296 6/20 (30%)
leucine-rich repeat 276..299 CDD:275380 6/22 (27%)
LRR 284..>630 CDD:443914 96/363 (26%)
LRR 11 299..320 4/20 (20%)
leucine-rich repeat 300..321 CDD:275380 4/20 (20%)
LRR 12 323..344 7/20 (35%)
LRR 13 356..377 8/22 (36%)
leucine-rich repeat 357..380 CDD:275380 9/24 (38%)
LRR 14 380..400 7/19 (37%)
leucine-rich repeat 381..406 CDD:275380 8/24 (33%)
LRR 15 408..429 6/20 (30%)
leucine-rich repeat 409..432 CDD:275380 6/22 (27%)
LRR 16 432..454 6/21 (29%)
leucine-rich repeat 433..457 CDD:275380 6/23 (26%)
leucine-rich repeat 458..481 CDD:275380 6/23 (26%)
LRR 17 465..486 4/21 (19%)
leucine-rich repeat 482..507 CDD:275380 7/24 (29%)
LRR 18 507..528 8/20 (40%)
leucine-rich repeat 508..531 CDD:275380 8/22 (36%)
LRR 19 531..552 9/23 (39%)
leucine-rich repeat 532..563 CDD:275380 9/33 (27%)
LRR 20 563..584 7/20 (35%)
leucine-rich repeat 564..585 CDD:275380 8/20 (40%)
LRR 21 587..608 4/27 (15%)
leucine-rich repeat 588..611 CDD:275380 6/32 (19%)
LRR 22 611..632 4/20 (20%)
leucine-rich repeat 612..630 CDD:275380 3/17 (18%)
leucine-rich repeat 637..659 CDD:275380 4/27 (15%)
LRRCT 645..697 CDD:214507 13/100 (13%)
Tlr3_TMD 698..730 CDD:465595 10/36 (28%)
TIR 755..900 CDD:214587 41/143 (29%)
Toll-9NP_649214.1 LRR 198..537 CDD:443914 102/399 (26%)
leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..311 CDD:275380 4/22 (18%)
leucine-rich repeat 312..356 CDD:275380 16/57 (28%)
leucine-rich repeat 357..381 CDD:275380 10/28 (36%)
leucine-rich repeat 382..397 CDD:275380 4/14 (29%)
leucine-rich repeat 405..430 CDD:275380 12/47 (26%)
leucine-rich repeat 432..453 CDD:275380 7/24 (29%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
leucine-rich repeat 478..501 CDD:275380 9/33 (27%)
leucine-rich repeat 502..525 CDD:275380 9/22 (41%)
TIR 751..891 CDD:214587 41/142 (29%)
Blue background indicates that the domain is not in the aligned region.

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