DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR3 and Toll-6

DIOPT Version :10

Sequence 1:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens
Sequence 2:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:1086 Identity:218/1086 - (20%)
Similarity:401/1086 - (36%) Gaps:312/1086 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    22 ASSTTKCTVSHEVADCSHLKLTQVP-DDLPT--------------------------NITVLNLT 59
            :||:|.|::..|..|.||.....:| :...|                          |:.:|||:
  Fly   269 SSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLS 333

Human    60 HNQLRRLPAANFTRYSQ-LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQ--LSDKTFAF 121
            .|::..||...|...:: :..:.:..|:||.|.|:|...|..|:.|:|..|:::.  :...||..
  Fly   334 SNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVG 398

Human   122 CTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQAL 186
            ...|..|:|..|.:.|::...|.....|..|:|.||.|.:....|...:.||..||||:||::.|
  Fly   399 LIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYL 463

Human   187 KSEEL---------------------DIFAN-SSLKKLELSSNQIKE------------------ 211
            .:..|                     |.|.| |:|:.|.|:.||:|.                  
  Fly   464 DAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGE 528

Human   212 -----FSPGCFHAIGRLFGL-----FLNNVQLG-----PSLTEKLCLELA--------------N 247
                 .....|..:|.|:||     :|.|:.:.     |:|.   .|.||              .
  Fly   529 NMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQ---ILNLARNRIAVVEPGAFEMT 590

Human   248 TSIRNLSLSNSQLSTTSN--TTFLGLKWTN-----------------LTMLDLSYNNLNVVGN-- 291
            :||:.:.|..::|:..:.  :....|.|.|                 |..|||..|.|:.:.|  
  Fly   591 SSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRF 655

Human   292 --DSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLN-------------LKRSFTKQSISLA 341
              ||...|..|:   :.:|.:|.:...|:.....:.:||             .|.:.|:..:...
  Fly   656 GLDSELKLQTLD---VSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYAN 717

Human   342 SLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTS--------LRTL-- 396
            .:..:|..|.:.|...||..:.:..|.|   |.||...|:.:|...|..||        |.|:  
  Fly   718 QITTLDIKSLRILPVWEHRALPEFYIGG---NPFTCDCNIDWLQKINHITSRQYPRIMDLETIYC 779

Human   397 -----TNETFVSLAHS-PLHILNLTKNKISKI----ESDAF----------------SWLGHL-E 434
                 ....::.|..: |.|.|...|.....:    |.||.                :|..:: |
  Fly   780 KLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVE 844

Human   435 VLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSP 499
            ......:|:.:.:.       .:..|:|:..|.:::|..:||          |.|          
  Fly   845 CSGAAYSEMPRRVP-------MDTSELYIDGNNFVELAGHSF----------LGR---------- 882

Human   500 SPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHL 564
                  :||.:|..:|:|:|:|.:....||::|.||.|:.|                        
  Fly   883 ------KNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDN------------------------ 917

Human   565 HILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKV 629
            ||::||.|.|..:  |..::|:      |..|.:.::....|.....|:.|.|..|.:...|...
  Fly   918 HIISLEGNEFHNL--ENLRELY------LQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQ 974

Human   630 FGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELS---------------------- 672
            .. |...|.|:.:..|.:.|.|..:|.|.|::.::...|.:.|                      
  Fly   975 LS-ANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCT 1038

Human   673 -----SHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV--LLIHFEGWRI 730
                 :||:               .|:..:...|   ..::.|...:.|..::  |..:....:|
  Fly  1039 LRDGVAHYM---------------HTNEIEGLLP---LLLVATCAFVAFFGLIFGLFCYRHELKI 1085

Human   731 SFYWNVSVHRVLGF-----KEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEE 790
               |..|.:.::.|     :.:|:..::....||..::.:|:.:|.:..:...:.|...:.||..
  Fly  1086 ---WAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHY 1147

Human   791 RDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEI 855
            ||.....:..:|::.:.:.:::.:.|::.:.|.:. ..||:...|:.:.:::. ..::.:...::
  Fly  1148 RDVNINAYITDALIEAAESAKQFVLVLSKNFLYNE-WSRFEYKSALHELVKRR-KRVVFILYGDL 1210

Human   856 PDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKN 901
            |...::  :.:|..:..|.|| .|..:|     |..||::||...|
  Fly  1211 PQRDID--MDMRHYLRTSTCI-EWDDKK-----FWQKLRLALPLPN 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR3NP_003256.1 leucine-rich repeat 33..52 CDD:275380 6/45 (13%)
LRR <36..309 CDD:443914 89/394 (23%)
LRR 1 52..73 8/20 (40%)
leucine-rich repeat 53..76 CDD:275380 7/22 (32%)
LRR 2 76..97 6/21 (29%)
leucine-rich repeat 77..100 CDD:275380 7/22 (32%)
LRR 3 100..121 6/22 (27%)
leucine-rich repeat 101..124 CDD:275380 6/24 (25%)
LRR 4 124..145 6/20 (30%)
leucine-rich repeat 125..148 CDD:275380 6/22 (27%)
LRR 5 148..168 7/19 (37%)
leucine-rich repeat 149..198 CDD:275380 20/70 (29%)
LRR 6 172..193 10/41 (24%)
LRR 7 198..219 7/43 (16%)
leucine-rich repeat 199..249 CDD:275380 18/96 (19%)
LRR 8 222..244 7/31 (23%)
LRR 9 249..270 4/22 (18%)
leucine-rich repeat 250..275 CDD:275380 5/26 (19%)
LRR 10 275..296 10/41 (24%)
leucine-rich repeat 276..299 CDD:275380 10/26 (38%)
LRR 284..>630 CDD:443914 80/399 (20%)
LRR 11 299..320 4/20 (20%)
leucine-rich repeat 300..321 CDD:275380 4/20 (20%)
LRR 12 323..344 4/33 (12%)
LRR 13 356..377 6/20 (30%)
leucine-rich repeat 357..380 CDD:275380 7/22 (32%)
LRR 14 380..400 7/34 (21%)
leucine-rich repeat 381..406 CDD:275380 7/39 (18%)
LRR 15 408..429 7/40 (18%)
leucine-rich repeat 409..432 CDD:275380 7/42 (17%)
LRR 16 432..454 2/22 (9%)
leucine-rich repeat 433..457 CDD:275380 2/24 (8%)
leucine-rich repeat 458..481 CDD:275380 6/22 (27%)
LRR 17 465..486 4/20 (20%)
leucine-rich repeat 482..507 CDD:275380 2/24 (8%)
LRR 18 507..528 7/20 (35%)
leucine-rich repeat 508..531 CDD:275380 8/22 (36%)
LRR 19 531..552 5/20 (25%)
leucine-rich repeat 532..563 CDD:275380 5/30 (17%)
LRR 20 563..584 7/20 (35%)
leucine-rich repeat 564..585 CDD:275380 7/20 (35%)
LRR 21 587..608 3/20 (15%)
leucine-rich repeat 588..611 CDD:275380 3/22 (14%)
LRR 22 611..632 5/20 (25%)
leucine-rich repeat 612..630 CDD:275380 5/17 (29%)
leucine-rich repeat 637..659 CDD:275380 7/21 (33%)
LRRCT 645..697 CDD:214507 11/78 (14%)
Tlr3_TMD 698..730 CDD:465595 4/33 (12%)
TIR 755..900 CDD:214587 27/144 (19%)
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697
leucine-rich repeat 202..278 CDD:275380 4/8 (50%)
leucine-rich repeat 229..249 CDD:275380
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR 299..654 CDD:443914 80/357 (22%)
leucine-rich repeat 303..326 CDD:275380 0/22 (0%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 6/24 (25%)
leucine-rich repeat 402..425 CDD:275380 6/22 (27%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 9/22 (41%)
leucine-rich repeat 474..497 CDD:275380 3/22 (14%)
leucine-rich repeat 498..518 CDD:275380 6/19 (32%)
leucine-rich repeat 521..544 CDD:275380 1/22 (5%)
leucine-rich repeat 545..566 CDD:275380 5/20 (25%)
leucine-rich repeat 569..592 CDD:275380 4/25 (16%)
leucine-rich repeat 593..615 CDD:275380 3/21 (14%)
leucine-rich repeat 616..637 CDD:275380 3/20 (15%)
leucine-rich repeat 638..662 CDD:275380 9/23 (39%)
LRR_8 662..719 CDD:404697 9/59 (15%)
leucine-rich repeat 663..684 CDD:275380 5/23 (22%)
leucine-rich repeat 685..708 CDD:275380 3/22 (14%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR <863..>990 CDD:443914 41/185 (22%)
leucine-rich repeat 885..908 CDD:275380 8/22 (36%)
leucine-rich repeat 909..932 CDD:275380 11/48 (23%)
leucine-rich repeat 933..956 CDD:275380 4/28 (14%)
TIR 1114..1247 CDD:214587 27/142 (19%)
Blue background indicates that the domain is not in the aligned region.

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