Protein Alignment TLR3 and ltl

DIOPT Version :10

• Sequence 1: NP_003256.1
• Gene: TLR3 / 7098
• HGNCID: 11849
• Length: 904
• Species: Homo sapiens
• Sequence 2: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Alignment Length: 692
• Identity: 156/692 - (22%)
• Similarity: 242/692 - (34%)
• Gaps: 233/692 - (33%)

Human    24 STTKCTVSHEVADC--------SHLKLT--------QVPDDL------PTNITVLNLTHNQLRRL 66
            ::.:|:|..|::.|        :|::|:        .|.|.|      .|||. |.:||:||..|
  Fly    12 ASLQCSVRPEISPCTCETGKAWNHVELSCEKLESFNAVVDSLANKLNADTNID-LKITHSQLDDL 75

Human    67 PAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM 131
            ...:||        |:.||               |..|.:|.|.|..|.:..|...:|:|.|.:.
  Fly    76 EMRSFT--------DMNFN---------------LYKLRMQWNSLKSLPEVPFRGLSNVTYLSIG 117

Human   132 SNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN 196
            .|.:.:|..:......:|:|||:....:.:.:......::.:..|:|.:|.|..|......
  Fly   118 DNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFP---- 178

Human   197 SSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLS 261
            .||..|.|..||::..: |..|.:..|..||:|                ||
  Fly   179 KSLLILHLGRNQLESLN-GSLHDLHNLESLFIN----------------AN-------------- 212

Human   262 TTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSH--SLHGLFNV 324
                         |:|.||           |......||.......|.::.|.::  .:|.|..|
  Fly   213 -------------NITSLD-----------DELPDGGQLRLLMAHNNRLERLPANMAGMHSLETV 253

Human   325 R-YLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSN 388
            . :.|..|||.:...:..:|.::               |.||:             .|:||:
  Fly   254 HIHCNQLRSFDRVLRNAVNLSEV---------------MADNN-------------ELEYLA--- 287

Human   389 SFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWR 453
                     .:.|.|.  |.:..|.:..|.|..:.|.....| .|:..:...|:| :|.:..|..
  Fly   288 ---------QDEFASC--SKVETLQMGCNHIKSLNSSLLPIL-KLKNANFSFNDI-EEFSMAELH 339

Human   454 GLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI 518
            ||.::        |.|||:.|      .:|||:          ..|...|.|. |..|||.||.|
  Fly   340 GLRSL--------KTLQLSSN------RIQRLL----------PDPRGVQELM-LVNLDLDNNRI 379

Human   519 ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFK 583
                 |.|.|.                            |.||.:|.||||..|..:.:.|..|.
  Fly   380 -----DSLNGA----------------------------LAGLGNLRILNLAGNRLEHLQVGDFD 411

Human   584 DLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFD 648
            .:..|.|:||..|.|           ..||.|.:  .|:.|:  |:...|:.|:|:|:..|....
  Fly   412 GMIRLDILDLTGNQL-----------AELKPLEM--TLLPSL--KILKVAYNNITKLEQDFKGLP 461

Human   649 CTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRL 690
            ..|::        |.|:..|..:||..:.||....|..|.:|
  Fly   462 VLCQA--------NLTNNQISTISSELVTNTRCKNHNVPGKL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLR3	NP_003256.1	leucine-rich repeat	33..52	CDD:275380	7/40 (18%)
		LRR	<36..309	CDD:443914	62/294 (21%)
		LRR 1	52..73		9/20 (45%)
		leucine-rich repeat	53..76	CDD:275380	9/22 (41%)
		LRR 2	76..97		3/20 (15%)
		leucine-rich repeat	77..100	CDD:275380	3/22 (14%)
		LRR 3	100..121		7/20 (35%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR 4	124..145		5/20 (25%)
		leucine-rich repeat	125..148	CDD:275380	4/22 (18%)
		LRR 5	148..168		4/19 (21%)
		leucine-rich repeat	149..198	CDD:275380	9/48 (19%)
		LRR 6	172..193		5/20 (25%)
		LRR 7	198..219		7/20 (35%)
		leucine-rich repeat	199..249	CDD:275380	13/49 (27%)
		LRR 8	222..244		4/21 (19%)
		LRR 9	249..270		0/20 (0%)
		leucine-rich repeat	250..275	CDD:275380	0/24 (0%)
		LRR 10	275..296		5/20 (25%)
		leucine-rich repeat	276..299	CDD:275380	4/22 (18%)
		LRR	284..>630	CDD:443914	78/348 (22%)
		LRR 11	299..320		4/22 (18%)
		leucine-rich repeat	300..321	CDD:275380	4/22 (18%)
		LRR 12	323..344		5/21 (24%)
		LRR 13	356..377		3/20 (15%)
		leucine-rich repeat	357..380	CDD:275380	3/22 (14%)
		LRR 14	380..400		3/19 (16%)
		leucine-rich repeat	381..406	CDD:275380	5/24 (21%)
		LRR 15	408..429		4/20 (20%)
		leucine-rich repeat	409..432	CDD:275380	5/22 (23%)
		LRR 16	432..454		5/21 (24%)
		leucine-rich repeat	433..457	CDD:275380	7/23 (30%)
		leucine-rich repeat	458..481	CDD:275380	5/22 (23%)
		LRR 17	465..486		7/20 (35%)
		leucine-rich repeat	482..507	CDD:275380	6/24 (25%)
		LRR 18	507..528		9/20 (45%)
		leucine-rich repeat	508..531	CDD:275380	10/22 (45%)
		LRR 19	531..552		0/20 (0%)
		leucine-rich repeat	532..563	CDD:275380	3/30 (10%)
		LRR 20	563..584		8/20 (40%)
		leucine-rich repeat	564..585	CDD:275380	8/20 (40%)
		LRR 21	587..608		6/20 (30%)
		leucine-rich repeat	588..611	CDD:275380	6/22 (27%)
		LRR 22	611..632		6/20 (30%)
		leucine-rich repeat	612..630	CDD:275380	6/17 (35%)
		leucine-rich repeat	637..659	CDD:275380	4/21 (19%)
		LRRCT	645..697	CDD:214507	11/46 (24%)
		Tlr3_TMD	698..730	CDD:465595
		TIR	755..900	CDD:214587
ltl	NP_729265.1	LRR	65..476	CDD:443914	137/617 (22%)
		leucine-rich repeat	65..86	CDD:275380	9/28 (32%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		leucine-rich repeat	135..158	CDD:275380	4/22 (18%)
		leucine-rich repeat	159..180	CDD:275380	5/24 (21%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	11/75 (15%)
		leucine-rich repeat	227..249	CDD:275380	3/21 (14%)
		leucine-rich repeat	250..272	CDD:275380	6/21 (29%)
		leucine-rich repeat	273..296	CDD:275380	9/64 (14%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		leucine-rich repeat	320..335	CDD:275378	4/15 (27%)
		leucine-rich repeat	344..366	CDD:275380	9/45 (20%)
		leucine-rich repeat	367..391	CDD:275380	14/57 (25%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	10/35 (29%)
		leucine-rich repeat	440..462	CDD:275380	6/23 (26%)
		leucine-rich repeat	463..483	CDD:275380	6/27 (22%)